INT85639

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 95
Total Number 96
Disease Relevance 24.83
Pain Relevance 15.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 16
brain 3
spinal cord 3
internal 3
Bone marrow 2
Tg(CAG-EGFP)D4Nagy (Mus musculus)
Tg(CAG-EGFP)D4Nagy - S65T (1)
Pain Link Frequency Relevance Heat
Spinal cord 747 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
gABA 145 99.96 Very High Very High Very High
Pyramidal cell 190 99.92 Very High Very High Very High
fluoxetine 11 99.82 Very High Very High Very High
Glutamate 94 99.74 Very High Very High Very High
opioid receptor 12 99.70 Very High Very High Very High
Desipramine 11 99.54 Very High Very High Very High
imagery 420 99.48 Very High Very High Very High
tetrodotoxin 8 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 715 99.92 Very High Very High Very High
Disease 238 99.72 Very High Very High Very High
Ebola Virus Infection 55 99.56 Very High Very High Very High
Skin Cancer 13 99.42 Very High Very High Very High
Injury 375 99.40 Very High Very High Very High
Cytomegalovirus Infection 46 99.38 Very High Very High Very High
Generalized Anxiety Disorder 9 98.92 Very High Very High Very High
Infection 148 98.48 Very High Very High Very High
Metastasis 84 98.36 Very High Very High Very High
Aging 157 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An Alexa-labeled siRNA was electro-transferred into murine melanoma cells stably-expressing the enhanced green fluorescent protein (eGFP) target reporter gene.
Positive_regulation (enhanced) of eGFP associated with skin cancer
1) Confidence 0.43 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Abstract Doc Link PMC2737239 Disease Relevance 0.25 Pain Relevance 0.05
Previously, we generated B16-F10 melanoma cell line stably-expressing enhanced green fluorescent protein (eGFP) and showed that electrical treatment led to siRNA-mediated endogenous gene silencing in solid tumors (Golzio et al, 2007).
Positive_regulation (enhanced) of eGFP in B16-F10 associated with solid tumor and skin cancer
2) Confidence 0.40 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.39 Pain Relevance 0
The immunohistochemical profile of GFP(-) and GFP(+) macrophages was similar but distal GFP(-) macrophages were differentially activated than their GFP(+) counterparts.
Positive_regulation (activated) of GFP in macrophages
3) Confidence 0.38 Published 2008 Journal Glia Section Abstract Doc Link 18383339 Disease Relevance 0.59 Pain Relevance 0.38
To address this question by developing a sensitive detection method, we generated transgenic mice expressing enhanced green fluorescent protein (GFP) under the specific transcriptional control of the PPE gene.
Positive_regulation (enhanced) of GFP associated with targeted disruption
4) Confidence 0.37 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 19046386 Disease Relevance 0.27 Pain Relevance 0.12
However, the lack of GFP accumulation in an HD mouse model (R6/2) crossed to our GFP?
Positive_regulation (accumulation) of GFP associated with disease
5) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.40 Pain Relevance 0
As shown in Figure 2A, increased GFP?
Positive_regulation (increased) of GFP
6) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.16 Pain Relevance 0.06
Upregulation of GFP?
Positive_regulation (Upregulation) of GFP
7) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.13 Pain Relevance 0
Upregulation of GFP?
Positive_regulation (Upregulation) of GFP
8) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.12 Pain Relevance 0
mice exhibit a dose-dependent induction of GFP?
Positive_regulation (induction) of GFP
9) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.14 Pain Relevance 0.05
Coculture experiments with cultured neurospheres isolated from enhanced green fluorescent protein (eGFP) transgenic mice demonstrated that differentiating eGFP-positive neurons were integrated into the intestinal tissue culture.
Positive_regulation (enhanced) of eGFP in neurons associated with targeted disruption
10) Confidence 0.26 Published 2007 Journal Dev. Dyn. Section Abstract Doc Link 16894627 Disease Relevance 0.10 Pain Relevance 0.24
Samples were then cooled to room temperature, and PCR performed using GFP specific primers (5?
Positive_regulation (using) of GFP
11) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.22 Pain Relevance 0
upregulation in the MG132-injected mice, it was possible to detect GFP?
Positive_regulation (upregulation) of GFP
12) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.22 Pain Relevance 0
mRNA levels between MG132-treated and untreated cells, confirming that the increase in GFP?
Positive_regulation (increase) of GFP
13) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.05 Pain Relevance 0
Confirming our observations from primary neuronal cultures, injection of MG132 led to a prominent increase in cortical GFP?
Positive_regulation (increase) of GFP in neuronal
14) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.19 Pain Relevance 0
Lastly, we consider it very unlikely that any significant downregulation of Ebf2 occurs, because: (1) CR neurons express GFP up to the point that they die; (2) levels of GFP expression were relatively stable throughout postnatal development, even when CR neurons survived to 2 months of age (Figure 4); and (3) We do not observe a gradual increase in the number of reelin+/GFP?
Positive_regulation (increase) of GFP in neurons
15) Confidence 0.20 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0.13 Pain Relevance 0
In the GIN transgenic line [35], GFP expression level is sufficient for in vivo imaging of somatostatin-positive interneurons, but the dense labeling of overlapping dendritic arbors prevented tracking of dendritic branches longer than ?
Positive_regulation (sufficient) of GFP in dendritic arbors associated with targeted disruption, somatostatin and imagery
16) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289876 Disease Relevance 0.10 Pain Relevance 0.17
Some of these specimens were immediately subjected to observation for EGFP fluorescence under a fluorescence stereomicroscope (SZX12, Olympus, Tokyo, Japan) with DM505 filters (BP460–490 and BA515IF, Olympus).
Positive_regulation (observation) of EGFP
17) Confidence 0.18 Published 2004 Journal BMC Nephrol Section Body Doc Link PMC419703 Disease Relevance 0.18 Pain Relevance 0
Following intrinsic optical imaging, we targeted injections of the lentivector encoding GFP and Cre to the C2 barrel column of such Rosa26R mice (n?
Positive_regulation (encoding) of GFP associated with imagery
18) Confidence 0.15 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0.09 Pain Relevance 0.12
We transfected cultures of mouse spinal cord slices with the enhanced green fluorescent protein (GFP) gene driven by the promoter for preproenkephalin, using the particle-mediated gene transfer system adapted for small neurons in the superficial dorsal horn, and observations were made after 4-6 days in vitro.
Positive_regulation (enhanced) of GFP in neurons associated with dorsal horn and spinal cord
19) Confidence 0.15 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16154691 Disease Relevance 0 Pain Relevance 0.32
After instillation of thioglycollate for 24 h to induce peritonitis, Ccr2RFP/+Cx3cr1GFP/+ F4/80dim monocytes were actively recruited to the peritoneum, and almost all expressed high levels of both RFP and GFP (Figure 3A).
Positive_regulation (levels) of GFP in peritoneum associated with peritonitis
20) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.25 Pain Relevance 0

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