INT85653

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Context Info
Confidence 0.24
First Reported 1999
Last Reported 2010
Negated 2
Speculated 5
Reported most in Body
Documents 24
Total Number 29
Disease Relevance 20.55
Pain Relevance 5.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
Mphi 2
HGF 2
central nervous system 2
endothelial cell 2
muscle tissues 2
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 69 100.00 Very High Very High Very High
Central nervous system 2 99.68 Very High Very High Very High
metalloproteinase 60 99.40 Very High Very High Very High
Inflammation 262 98.24 Very High Very High Very High
Pain 14 97.56 Very High Very High Very High
Arthritis 13 96.68 Very High Very High Very High
cINOD 148 89.52 High High
Inflammatory mediators 10 89.12 High High
Bile 2 88.60 High High
tolerance 10 86.16 High High
Disease Link Frequency Relevance Heat
Apoptosis 155 100.00 Very High Very High Very High
Death 19 100.00 Very High Very High Very High
Repression 3 100.00 Very High Very High Very High
Gastrointestinal Neoplasms 1 100.00 Very High Very High Very High
Adhesions 157 99.90 Very High Very High Very High
Cancer 510 99.64 Very High Very High Very High
Pancreatic Cancer 252 99.28 Very High Very High Very High
Malignant Neoplastic Disease 16 98.98 Very High Very High Very High
INFLAMMATION 318 98.24 Very High Very High Very High
Myositis 108 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical analyses of the primary splenic tumor in rofecoxib-treated mice showed no alteration in COX-1 expression, but significant decreases in the expression of the tumor-promoting proteins COX-2, cyclin D1, cytosolic beta-catenin, matrix metalloproteinases-2 and -9, and vascular endothelial cell- derived growth factor.
Neg (no) Regulation (alteration) of Gene_expression (expression) of COX in endothelial cell associated with cancer and metalloproteinase
1) Confidence 0.24 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566300 Disease Relevance 1.42 Pain Relevance 0.31
Several studies support a role of COX products in the central nervous system response to infectious stimuli.
Regulation (role) of Gene_expression (products) of COX in central nervous system associated with central nervous system
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904706 Disease Relevance 1.25 Pain Relevance 0.26
In the present study, we investigated the effects of methanolic extracts of CB and DC on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 expression in mouse skin.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of COX in skin
3) Confidence 0.23 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15639337 Disease Relevance 0.46 Pain Relevance 0.23
To clarify the roles of cyclooxygenase (COX) in malignant tumor development and angiogenesis, we investigated the effects of COX inhibitors on two kinds of gastrointestinal cancer xenograft, one of which overexpresses COX-2 and the other expresses no COX, in nude mice in vivo.
Spec (investigated) Regulation (effects) of Gene_expression (overexpresses) of COX associated with malignant neoplastic disease and gastrointestinal neoplasms
4) Confidence 0.21 Published 1999 Journal Lab. Invest. Section Abstract Doc Link 10616198 Disease Relevance 0.64 Pain Relevance 0.03
Different types of tumor promoters elevate COX-2 expression in keratinocytes, with little change in COX-1, suggesting that there are multiple signaling pathways by which COX-2 expression can be regulated.
Regulation (regulated) of Gene_expression (expression) of COX in keratinocytes associated with cancer
5) Confidence 0.20 Published 2002 Journal J. Environ. Pathol. Toxicol. Oncol. Section Abstract Doc Link 12086405 Disease Relevance 0.26 Pain Relevance 0
This review focuses on the regulation of PGE2 production in murine Mphi; the age-associated changes in COX-2 expression; and its implication for certain disorders observed in the aged immune system and brain.
Regulation (changes) of Gene_expression (expression) of COX in Mphi
6) Confidence 0.19 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15331118 Disease Relevance 0.52 Pain Relevance 0.14
None of the test samples had any immediate effect on the expression of the mucosal COX isoforms.
Regulation (effect) of Gene_expression (expression) of COX
7) Confidence 0.12 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.15 Pain Relevance 0
The deletion of COX-2, normally localized at nuclear envelope [11], might affect the expression of genes directly or indirectly coupled with COX-2.
Spec (might) Regulation (affect) of Gene_expression (expression) of COX
8) Confidence 0.11 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.09 Pain Relevance 0.16
The usage of high-throughput technology such as microarray analysis can enhance our ability to characterize the effect of deleting the expression of either COX-1 or COX-2 on the expression of networks of genes normally controlled by the end products of these individual COX isoforms.
Regulation (effect) of Gene_expression (expression) of COX
9) Confidence 0.11 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.29 Pain Relevance 0.07
Although not well understood, evidence for regulation of COX expression at the post-transcriptional level is increasing [44, 45].
Regulation (regulation) of Gene_expression (expression) of COX
10) Confidence 0.11 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.40 Pain Relevance 0.28
We will investigate whether the expression levels of these cytokines in serum, and the COX-2 level in paw tissue, are changed by treatment with CP extract.
Spec (whether) Regulation (changed) of Gene_expression (expression) of COX in paw associated with cytokine
11) Confidence 0.08 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 0.85 Pain Relevance 0.50
However, the traditional description of COX-1 as a purely constitutive, housekeeping gene has been recently challenged by several studies, which have found that COX-1 production can also be regulated at the transcriptional level [27].
Regulation (regulated) of Gene_expression (production) of COX
12) Confidence 0.07 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1634873 Disease Relevance 1.14 Pain Relevance 0.37
A protumorigenic role for COX enzymes and COX-derived PGs has also been inferred from epidemiologic analyses.
Regulation (role) of Gene_expression (enzymes) of COX
13) Confidence 0.06 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 1.28 Pain Relevance 0.34
Effects of immunosuppressive treatment on PGES and COX expression
Regulation (Effects) of Gene_expression (expression) of COX
14) Confidence 0.06 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 0.69 Pain Relevance 0.10
Molecular mechanisms of COX and LOX-mediated pancreatic cancer development
Regulation (Molecular) of Gene_expression (mechanisms) of COX associated with pancreatic cancer
15) Confidence 0.05 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.28 Pain Relevance 0.05
Forced COX-2 expression significantly attenuated TRAIL-induced apoptosis and was associated with transcriptional repression of death receptor-5 and up-regulation of Bcl-2 [89].
Regulation (regulation) of Gene_expression (expression) of COX associated with repression, apoptosis and death
16) Confidence 0.05 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.30 Pain Relevance 0.24
Mitogenic effects of COX and LOX metabolites
Regulation (metabolites) of Gene_expression (effects) of COX
17) Confidence 0.05 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.21 Pain Relevance 0.03
We also examined the effects of conventional immunosuppressive treatment on muscle functional activity, muscle histopathology and expression of mPGES-1/COX in muscle tissues.
Spec (examined) Regulation (effects) of Gene_expression (expression) of COX in muscle tissues
18) Confidence 0.05 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 0.86 Pain Relevance 0.29
In so doing it modulates the expression and activity of COX-2 and certain MMPs.
Regulation (modulates) of Gene_expression (expression) of COX associated with metalloproteinase
19) Confidence 0.05 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.48 Pain Relevance 0.20
Our results demonstrate that tryptophan catabolism has significant effects on cell adhesion and regulates the activity and expression of cyclooxygenases 1 and 2 (COX-1 and -2).


Regulation (regulates) of Gene_expression (expression) of COX associated with adhesions
20) Confidence 0.05 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.42 Pain Relevance 0.10

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