INT85655

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Context Info
Confidence 0.68
First Reported 2000
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 9.34
Pain Relevance 6.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Crhr1) plasma membrane (Crhr1) response to stress (Crhr1)
signal transducer activity (Crhr1)
Anatomy Link Frequency
Bar 1
pituitary 1
lamina 1
corticotroph 1
ventral 1
Crhr1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 98 99.96 Very High Very High Very High
Central grey 2 99.92 Very High Very High Very High
amygdala 306 99.68 Very High Very High Very High
withdrawal 36 99.56 Very High Very High Very High
Ventral tegmentum 6 99.36 Very High Very High Very High
Dopamine 15 99.26 Very High Very High Very High
Nucleus accumbens 10 97.28 Very High Very High Very High
opiate 14 97.00 Very High Very High Very High
Morphine 24 95.92 Very High Very High Very High
Dynorphin 98 95.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 302 100.00 Very High Very High Very High
Stress 265 100.00 Very High Very High Very High
Urological Neuroanatomy 4 99.92 Very High Very High Very High
Targeted Disruption 159 99.88 Very High Very High Very High
Aggression 441 98.52 Very High Very High Very High
Disorders Of The Lacrimal System 2 96.52 Very High Very High Very High
Weight Loss 3 96.00 Very High Very High Very High
Alcohol Addiction 32 93.64 High High
Sprains And Strains 68 93.48 High High
INFLAMMATION 4 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously found that icv injection of the CRF receptor antagonist, D-Phe-CRF12–41 (1.0 and 5.0 ?
Gene_expression (injection) of CRF receptor associated with antagonist
1) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 1.15 Pain Relevance 0.17
We recently showed that mice missing CRFR2 exhibit impaired maternal aggression, but normal pup retrieval behavior [16] and speculated that the overproduction of CRF in these CRFR2 knockout mice acting on an intact CRFR1 was responsible for the deficits in aggression.
Gene_expression (acting) of CRFR1 associated with targeted disruption and aggression
2) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.97 Pain Relevance 0
Given that central release of CRF acting on CRFR1 is an important mediator of the behavioral responses to stress, it would be interesting in future studies to examine whether or how CRFR1-/- and WT mice differ in how postpartum stressors affect maternal aggression.
Gene_expression (acting) of CRFR1 associated with stress and aggression
3) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.92 Pain Relevance 0.16
Further, to overcome any deleterious effects of maternal deficiencies in glucocorticoids in CRFR1-/- mice, all mice were mated with outbred mice so that progeny would not be missing the CRFR1 gene.
Neg (not) Gene_expression (missing) of CRFR1 gene
4) Confidence 0.68 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.57 Pain Relevance 0
Next the expression of CRF-R1 was determined as a second measure of the involvement of this receptor in opiate withdrawal.
Gene_expression (expression) of CRF-R1 associated with opiate and withdrawal
5) Confidence 0.62 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617121 Disease Relevance 0.43 Pain Relevance 1.09
CRFR1 is widely expressed throughout the CNS and it appears that activation of the receptor helps support the full expression of a subset of maternal behaviors.
Gene_expression (expressed) of CRFR1
6) Confidence 0.60 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.22 Pain Relevance 0
CRFR1-deficient male mice in an inbred C57BL/6 background [12] were produced by crossings of heterozygote CRFR1 (+/-) mice (The Jackson Laboratory, Bar Harbor, ME).
Gene_expression (produced) of CRFR1 in Bar
7) Confidence 0.60 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.40 Pain Relevance 0
The strongest co-distribution of CRF1 and CRF2 mRNAs with CRF and Ucn1 fibers appeared in lamina VII.
Gene_expression (co-distribution) of CRF1 in lamina
8) Confidence 0.60 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17444496 Disease Relevance 0.20 Pain Relevance 0.26
By crossing inbred mice with a deficiency into hsd:ICR mice selectively bred for high maternal aggression, all mice in this study had a mixed inbred:outbred (50:50) background that produced high fecundity in both WT and CRFR1-/- groups as evidenced by pregnancy rate and litter size.
Gene_expression (produced) of CRFR1 associated with aggression
9) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.65 Pain Relevance 0
Microarray results indicated the inhibitory effects of corticotropin-releasing factor (CRF) receptor 1 (CRFR1) and GR antagonists (antalarmin and RU486, respectively, blocked 65% of ethanol activation, P < 0.05) on gene expression activation of the B3 subcluster (Figure 4f, g).
Gene_expression (effects) of CRFR1 associated with antagonist
10) Confidence 0.57 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.17
Heterozygote CRFR1 (+/-) mice (with mixed inbred and outbred backgrounds) were then bred to produce WT and CRFR1-/- female mice used in this study.
Gene_expression (produce) of CRFR1
11) Confidence 0.53 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.48 Pain Relevance 0
Expression of CRF-R2, the other major CRF receptor subtype, was not down-regulated significantly by withdrawal in any of the regions examined, although morphine alone significantly increased levels of this receptor subtype.
Gene_expression (Expression) of CRF receptor associated with withdrawal and morphine
12) Confidence 0.48 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617121 Disease Relevance 0.42 Pain Relevance 1.20
In addition, CRF1-R has been shown to be expressed in high density within the BLA [47], [48].
Gene_expression (expressed) of CRF1-R associated with amygdala
13) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.43 Pain Relevance 0.73
mice is not clear, but it may be a consequence of the rewarding effects of dopamine release caused by CRF activation of CRF1-R expressing neurons in the ventral tegmental area [5], [35].
Gene_expression (expressing) of CRF1-R in ventral associated with ventral tegmentum and dopamine
14) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.41 Pain Relevance 0.59
CRF1 is a potent mediator of stress- and anxiety-related behaviors (Baldwin et al., 1991; Rassnick et al., 1993; Pich et al., 1995) and CRF1s are abundantly expressed in the CeA.
Gene_expression (expressed) of CRF1 associated with stress, anxiety disorder and amygdala
15) Confidence 0.34 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.37 Pain Relevance 0.30
CRF1 is a potent mediator of stress- and anxiety-related behaviors (Baldwin et al., 1991; Rassnick et al., 1993; Pich et al., 1995) and CRF1s are abundantly expressed in the CeA.
Gene_expression (expressed) of CRF1s associated with stress, anxiety disorder and amygdala
16) Confidence 0.34 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.37 Pain Relevance 0.30
Overall, our study has added a new player in the complex signaling pathways mediating ethanol and CRF1 effects in the CeA.
Gene_expression (effects) of CRF1 associated with amygdala
17) Confidence 0.30 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.39 Pain Relevance 0.61
There are nine isoforms of AC, but we recently found that CRF1 receptors in the pituitary were coupled to the Type 7 AC (AC7).
Gene_expression (receptors) of CRF1 in pituitary
18) Confidence 0.30 Published 2011 Journal Frontiers in Neuroscience Section Abstract Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.49
Alternatively, the expression of CRHR1 in corticotroph may be significantly up-regulated in the CRH deficiency.
Gene_expression (expression) of CRHR1 in corticotroph
19) Confidence 0.25 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.62 Pain Relevance 0.16
to adult rats increases CRF and the CRF1 receptor mRNA expression in the PVN with a delay of one week after treatment which potentiates the secretion of ACTH and causes a long-term HPA sensitization [51].
Gene_expression (expression) of CRF1 receptor mRNA
20) Confidence 0.04 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2845127 Disease Relevance 0.33 Pain Relevance 0.08

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