INT85667

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.54
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
spinal cord dorsal horn 2
nerve 1
dorsal horn 1
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 12 100.00 Very High Very High Very High
mu opioid receptor 9 100.00 Very High Very High Very High
agonist 5 100.00 Very High Very High Very High
Dorsal horn neuron 2 100.00 Very High Very High Very High
Eae 4 99.44 Very High Very High Very High
Spinal cord 6 99.20 Very High Very High Very High
Enkephalin 1 91.80 High High
potassium channel 1 88.88 High High
antagonist 1 83.44 Quite High
narcan 1 82.56 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 3 99.30 Very High Very High Very High
Nervous System Injury 3 97.90 Very High Very High Very High
Injury 1 75.00 Quite High
Ganglion Cysts 1 59.12 Quite High
Diabetes Mellitus 4 51.04 Quite High
Pain 2 39.52 Quite Low
Hypersensitivity 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The reduced analgesic effect of intrathecal morphine in diabetes is probably due to impairment of mu opioid receptor-G protein coupling rather than reduction in mu opioid receptor number in the spinal cord dorsal horn.


Negative_regulation (impairment) of Negative_regulation (reduction) of mu opioid receptor in spinal cord dorsal horn
1) Confidence 0.37 Published 2003 Journal Anesthesiology Section Body Doc Link 14639157 Disease Relevance 0.05 Pain Relevance 0
In both the spared nerve injury (SNI) and spinal nerve ligation (SNL) rat peripheral neuropathic pain models the presynaptic inhibitory effect of the mu opioid receptor (MOR) agonist (DAMGO) on primary afferent-evoked excitatory postsynaptic currents (EPSCs) and miniature EPSCs in superficial dorsal horn neurons is substantially reduced, but only in those spinal cord segments innervated by injured primary afferents.
Negative_regulation (reduced) of in nerve Negative_regulation (effect) of mu opioid receptor in dorsal horn associated with nervous system injury, eae, neuropathic pain, agonist, mu opioid receptor, dorsal horn neuron and spinal cord
2) Confidence 0.28 Published 2005 Journal Pain Section Abstract Doc Link 16098668 Disease Relevance 0.49 Pain Relevance 0.68
Exposure of these cells to the MAPK kinase 1 inhibitor PD98059 not only prevented MAPK activation but also inhibited homologous desensitization of the mu-opioid receptor.
Negative_regulation (inhibited) of Negative_regulation (desensitization) of mu-opioid receptor associated with opioid receptor
3) Confidence 0.11 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617147 Disease Relevance 0 Pain Relevance 0.63

General Comments

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