INT85679

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Context Info
Confidence 0.39
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.79
Pain Relevance 3.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) transport (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Anatomy Link Frequency
spinal 1
Arrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 154 99.96 Very High Very High Very High
Pain 6 97.24 Very High Very High Very High
agonist 6 95.72 Very High Very High Very High
Morphine 56 93.68 High High
mu opioid receptor 20 92.72 High High
analgesia 6 92.12 High High
Analgesic 6 90.56 High High
Enkephalin 2 87.28 High High
Kinase C 4 86.92 High High
antinociception 1 80.28 Quite High
Disease Link Frequency Relevance Heat
Pain 5 97.24 Very High Very High Very High
Targeted Disruption 3 96.92 Very High Very High Very High
Opiate Addiction 10 79.44 Quite High
Nociception 1 77.68 Quite High
Constipation 1 68.48 Quite High
Respiratory Failure 1 67.04 Quite High
Neurodegenerative Disease 6 17.88 Low Low
Pheochromocytoma 10 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Helminth Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the general applicability of the (beta)arr2-muOR interaction in other neuronal systems, we have, in the present study, tested (beta)arr2 knock-out ((beta)arr2-KO) mice using the warm water tail-immersion paradigm, which primarily assesses spinal reflexes to painful thermal stimuli.
arr2 Binding (interaction) of in spinal associated with targeted disruption and pain
1) Confidence 0.39 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451149 Disease Relevance 0.35 Pain Relevance 1.10
The efficiency of GPCR signaling is tightly regulated and ultimately limited by the coordinated phosphorylation of the receptors by specific GPCR kinases and the subsequent interaction of the phosphorylated receptors with beta-arrestin 1 and beta-arrestin 2.
beta-arrestin 2 Binding (interaction) of
2) Confidence 0.39 Published 1999 Journal Science Section Abstract Doc Link 10617462 Disease Relevance 0.09 Pain Relevance 0.79
It is interesting that this compound, termed herkinorin, does not promote the recruitment of beta-arrestin-2 to the muOR and does not lead to receptor internalization.
beta-arrestin-2 Neg (not) Binding (recruitment) of
3) Confidence 0.20 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17090705 Disease Relevance 0.14 Pain Relevance 0.81
After phosphorylation of MOR, beta-arrestin 2 binds and mediates MOR internalization [20].
beta-arrestin 2 Binding (binds) of associated with opioid receptor
4) Confidence 0.01 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841195 Disease Relevance 0.22 Pain Relevance 1.13

General Comments

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