INT85681

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.79
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) transport (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Arrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 11 99.98 Very High Very High Very High
Root ganglion neuron 2 99.84 Very High Very High Very High
analgesia 3 99.82 Very High Very High Very High
Morphine 18 99.62 Very High Very High Very High
narcan 4 99.28 Very High Very High Very High
Analgesic 4 98.68 Very High Very High Very High
Pain 8 98.44 Very High Very High Very High
Enkephalin 1 96.44 Very High Very High Very High
opiate 4 95.60 Very High Very High Very High
agonist 8 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.86 Very High Very High Very High
Ganglion Cysts 2 99.52 Very High Very High Very High
Pain 6 98.44 Very High Very High Very High
Drug Dependence 1 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, they suggest that inhibition of beta-arrestin 2 function might lead to enhanced analgesic effectiveness of morphine and provide potential new avenues for the study and treatment of pain, narcotic tolerance, and dependence.
Negative_regulation (inhibition) of beta-arrestin 2 associated with addiction, pain, analgesic, tolerance and morphine
1) Confidence 0.47 Published 1999 Journal Science Section Abstract Doc Link 10617462 Disease Relevance 0.16 Pain Relevance 0.89
Enhanced morphine analgesia in mice lacking beta-arrestin 2.
Negative_regulation (lacking) of beta-arrestin 2 associated with narcan, analgesia and morphine
2) Confidence 0.47 Published 1999 Journal Science Section Title Doc Link 10617462 Disease Relevance 0.10 Pain Relevance 0.94
Using a knockout mouse lacking beta-arrestin-2 (beta arr2-/-), we have assessed the contribution of desensitization of the mu-opioid receptor to the development of morphine antinociceptive tolerance and the subsequent onset of physical dependence.
Negative_regulation (lacking) of beta-arrestin-2 associated with targeted disruption, physical dependence, tolerance, opioid receptor, antinociceptive and morphine
3) Confidence 0.42 Published 2000 Journal Nature Section Abstract Doc Link 11130073 Disease Relevance 0.35 Pain Relevance 1.22
A lack of beta-arrestin2 reduced the maximum inhibition of VGCCs by morphine and DAMGO (D-Ala2-N-Me-Phe4-glycol5-enkephalin) without affecting agonist potency, the onset of receptor desensitization, or the functional contribution of N-type VGCCs.
Negative_regulation (lack) of beta-arrestin2 associated with agonist, enkephalin, potency and morphine
4) Confidence 0.37 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17494695 Disease Relevance 0.17 Pain Relevance 0.64
In addition, morphine promotes the association of RGS9-2 with another essential component of MOR desensitization, beta-arrestin-2.
Negative_regulation (desensitization) of beta-arrestin-2 associated with opioid receptor and morphine
5) Confidence 0.15 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17725581 Disease Relevance 0 Pain Relevance 1.01

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox