INT85682

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Context Info
Confidence 0.46
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.22
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) transport (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Anatomy Link Frequency
neurons 1
spinal cord 1
Arrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 15 99.66 Very High Very High Very High
Morphine 14 99.50 Very High Very High Very High
Immobilon 8 99.14 Very High Very High Very High
Kinase C 1 98.68 Very High Very High Very High
Spinal cord 3 96.96 Very High Very High Very High
agonist 9 95.76 Very High Very High Very High
Analgesic 2 94.68 High High
antagonist 1 94.36 High High
Opioid 1 91.64 High High
tolerance 7 91.20 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 2 75.00 Quite High
Pain 2 73.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrated that repeated s.c. treatment with etorphine, but not morphine, produced a significant increase in protein levels of G protein-coupled receptor kinase 2, dynamin II, beta-arrestin 2 and phosphorylated-conventional protein kinase C in membranes of the mouse spinal cord, suggesting that the etorphine-induced mu-opioid receptor desensitization may result from G protein-coupled receptor kinase 2/dynaminII/beta-arrestin2-dependent phosphorylation of mu-opioid receptors.
Positive_regulation (increase) of beta-arrestin 2 in spinal cord associated with kinase c, mu opioid receptor, opioid receptor, spinal cord, morphine and immobilon
1) Confidence 0.46 Published 2006 Journal Neuroscience Section Abstract Doc Link 16417975 Disease Relevance 0 Pain Relevance 1.01
These functional changes were accompanied by diminished constitutive recycling and increased cell-surface mu receptor expression in beta arr2-/- compared with beta arr2+/+ neurons.
Positive_regulation (increased) of arr2 in neurons
2) Confidence 0.43 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17494695 Disease Relevance 0.15 Pain Relevance 0.66
These results provide evidence in vivo for the physiological importance of beta-arrestin 2 in regulating the function of a specific GPCR, the muOR.
Positive_regulation (importance) of beta-arrestin 2
3) Confidence 0.40 Published 1999 Journal Science Section Abstract Doc Link 10617462 Disease Relevance 0.07 Pain Relevance 0.86
A BRET assay suggested that DOR phosphorylation promotes receptor selectivity for beta-arrestin 2 over beta-arrestin 1.
Positive_regulation (promotes) of beta-arrestin 2 associated with opioid receptor
4) Confidence 0.37 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17565992 Disease Relevance 0 Pain Relevance 0.52

General Comments

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