INT85685

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Context Info
Confidence 0.74
First Reported 1999
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 9
Disease Relevance 0.66
Pain Relevance 5.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) transport (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Anatomy Link Frequency
hippocampus 3
striatum 2
Arrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 25 99.98 Very High Very High Very High
Hippocampus 10 99.84 Very High Very High Very High
Morphine 22 99.18 Very High Very High Very High
Central grey 4 98.78 Very High Very High Very High
Pain 3 97.76 Very High Very High Very High
Analgesic 2 97.24 Very High Very High Very High
opiate 9 95.60 Very High Very High Very High
Dopamine 7 94.80 High High
agonist 2 90.96 High High
dopamine receptor 1 89.48 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 98.78 Very High Very High Very High
Pain 3 97.76 Very High Very High Very High
Targeted Disruption 4 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, a single, distinct, and highly significant quantitative trait locus for Arrb2 expression in hippocampus and striatum was identified at the locus of this gene, providing evidence that genetic variation may affect a cis-regulatory mechanism for expression and regional control of Arrb2.
Gene_expression (expression) of Arrb2 in striatum associated with hippocampus
1) Confidence 0.74 Published 2008 Journal FASEB J. Section Abstract Doc Link 18367649 Disease Relevance 0 Pain Relevance 0.20
We identified elevated expression of the beta-arrestin 2 gene (Arrb2) in the striatum and the hippocampus of ethanol-preferring AA rats compared to their nonpreferring counterpart ANA line.
Gene_expression (expression) of Arrb2 in hippocampus associated with hippocampus
2) Confidence 0.74 Published 2008 Journal FASEB J. Section Abstract Doc Link 18367649 Disease Relevance 0 Pain Relevance 0.22
Furthermore, a single, distinct, and highly significant quantitative trait locus for Arrb2 expression in hippocampus and striatum was identified at the locus of this gene, providing evidence that genetic variation may affect a cis-regulatory mechanism for expression and regional control of Arrb2.
Gene_expression (expression) of Arrb2 in striatum associated with hippocampus
3) Confidence 0.64 Published 2008 Journal FASEB J. Section Abstract Doc Link 18367649 Disease Relevance 0 Pain Relevance 0.19
Mice lacking beta(arrestin)-2 (beta(arr2)) display enhanced sensitivity to morphine in tests of pain perception attributable to impaired desensitization of muOR.
Neg (lacking) Gene_expression (lacking) of arr2 associated with pain and morphine
4) Confidence 0.58 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614085 Disease Relevance 0.23 Pain Relevance 0.94
Functional deletion of the beta-arrestin 2 gene in mice resulted in remarkable potentiation and prolongation of the analgesic effect of morphine, suggesting that muOR desensitization was impaired.
Gene_expression (deletion) of beta-arrestin 2 gene associated with analgesic and morphine
5) Confidence 0.54 Published 1999 Journal Science Section Abstract Doc Link 10617462 Disease Relevance 0.08 Pain Relevance 0.81
These results suggest that induction of DOPr-mediated actions in PAG by chronic morphine requires prolonged MOPr stimulation and expression of beta-arrestin-2.
Gene_expression (expression) of beta-arrestin-2 associated with opioid receptor, central grey and morphine
6) Confidence 0.39 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15788776 Disease Relevance 0.34 Pain Relevance 1.37
Furthermore, a single, distinct, and highly significant quantitative trait locus for Arrb2 expression in hippocampus and striatum was identified at the locus of this gene, providing evidence that genetic variation may affect a cis-regulatory mechanism for expression and regional control of Arrb2.
Gene_expression (expression) of Arrb2 in hippocampus associated with hippocampus
7) Confidence 0.25 Published 2008 Journal FASEB J. Section Abstract Doc Link 18367649 Disease Relevance 0 Pain Relevance 0.20
In addition, morphine promotes the association of RGS9-2 with another essential component of MOR desensitization, beta-arrestin-2.
Gene_expression (desensitization) of beta-arrestin-2 associated with opioid receptor and morphine
8) Confidence 0.24 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17725581 Disease Relevance 0 Pain Relevance 1.01
Furthermore, a single, distinct, and highly significant quantitative trait locus for Arrb2 expression in hippocampus and striatum was identified at the locus of this gene, providing evidence that genetic variation may affect a cis-regulatory mechanism for expression and regional control of Arrb2.
Gene_expression (expression) of Arrb2 in hippocampus associated with hippocampus
9) Confidence 0.22 Published 2008 Journal FASEB J. Section Abstract Doc Link 18367649 Disease Relevance 0 Pain Relevance 0.19

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