INT8571

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1986
Last Reported 2010
Negated 5
Speculated 0
Reported most in Abstract
Documents 54
Total Number 55
Disease Relevance 36.85
Pain Relevance 15.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (B3GAT1) carbohydrate metabolic process (B3GAT1)
Anatomy Link Frequency
T cells 8
neurons 5
salivary gland 4
immune cells 3
natural killer cells 2
B3GAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 188 100.00 Very High Very High Very High
Neuropeptide 35 100.00 Very High Very High Very High
antagonist 106 99.96 Very High Very High Very High
Dorsal horn 4 99.88 Very High Very High Very High
Dorsal column 10 99.82 Very High Very High Very High
Peripheral nervous system 18 99.74 Very High Very High Very High
spinal inflammation 200 99.50 Very High Very High Very High
Inflammation 261 99.16 Very High Very High Very High
qutenza 121 99.04 Very High Very High Very High
interstitial cystitis 2 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 671 100.00 Very High Very High Very High
Carcinoma 35 100.00 Very High Very High Very High
Adenocarcinoma 11 100.00 Very High Very High Very High
Pleomorphic Adenoma 4 100.00 Very High Very High Very High
Adenoid Cystic Carcinoma 4 100.00 Very High Very High Very High
Disease 231 99.98 Very High Very High Very High
Small Cell Lung Carcinoma 6 99.84 Very High Very High Very High
Low Back Pain 216 99.50 Very High Very High Very High
INFLAMMATION 255 99.16 Very High Very High Very High
Stress 14 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the peripheral nervous system, tachykinin NK1 receptors are widely expressed in the respiratory, genitourinary and gastrointestinal tracts and are also expressed by several types of inflammatory and immune cells.
Gene_expression (expressed) of NK1 in immune cells associated with inflammation and peripheral nervous system
1) Confidence 0.75 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9571643 Disease Relevance 0.62 Pain Relevance 0.31
In the peripheral nervous system, tachykinin NK1 receptors are widely expressed in the respiratory, genitourinary and gastrointestinal tracts and are also expressed by several types of inflammatory and immune cells.
Gene_expression (expressed) of NK1 in immune cells associated with inflammation and peripheral nervous system
2) Confidence 0.75 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9571643 Disease Relevance 0.59 Pain Relevance 0.31
Conversely, although imipramine did not provide significant behavioral analgesia, it significantly blocked both pain- and stress-evoked alterations in hippocampal and spinal NK-1 and BDNF gene expression.
Gene_expression (expression) of NK-1 in spinal associated with stress, pain and analgesia
3) Confidence 0.75 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16956981 Disease Relevance 1.19 Pain Relevance 1.52
Reduced aversion to oral capsaicin following neurotoxic destruction of superficial medullary neurons expressing NK-1 receptors.
Gene_expression (expressing) of NK-1 in neurons associated with qutenza
4) Confidence 0.75 Published 2002 Journal Brain Res. Section Title Doc Link 12113962 Disease Relevance 0 Pain Relevance 0.87
Aversion to capsaicin (0.1-10 ppm) was assessed using a two-bottle paired preference paradigm, before and after intracisternal injection of substance P conjugated to saporin (SP-SAP) to ablate neurons in superficial medullary and cervical dorsal horn that express NK-1 receptors.
Gene_expression (express) of NK-1 in dorsal horn associated with qutenza, dorsal horn and substance p
5) Confidence 0.75 Published 2002 Journal Brain Res. Section Abstract Doc Link 12113962 Disease Relevance 0 Pain Relevance 0.56
Compared with wild-type NK1-R, the t(1/2) of SP-induced Ca(2+) mobilization was seven- and twofold greater in cells expressing NK1-Rdelta324 and NK1-RKC4, respectively.
Gene_expression (expressing) of NK1 associated with substance p
6) Confidence 0.75 Published 2001 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 11287322 Disease Relevance 0.14 Pain Relevance 0.89
This did not occur in cells expressing a COOH-terminally truncated NK1-R (NK1-Rdelta324), which may correspond to a naturally occurring variant, or a point mutant lacking eight potential PKC phosphorylation sites within the COOH tail (NK1-R Ser-338, Thr-339, Ser-352, Ser-387, Ser-388, Ser-390, Ser-392, Ser-394/Ala, NK1-RKC4).
Gene_expression (expressing) of NK1 in tail associated with kinase c
7) Confidence 0.75 Published 2001 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 11287322 Disease Relevance 0.17 Pain Relevance 0.75
Postsynaptic dorsal column neurons express NK1 receptors following colon inflammation.
Gene_expression (express) of NK1 in neurons associated with inflammation and dorsal column
8) Confidence 0.75 Published 2003 Journal Neuroscience Section Title Doc Link 12559111 Disease Relevance 0.24 Pain Relevance 0.62
The expression of Leu 7, Leu 9, and Leu 19, three antigens related to natural killer cells, was decreased by about 50%.
Gene_expression (expression) of Leu 7 in natural killer cells
9) Confidence 0.75 Published 1992 Journal Childs Nerv Syst Section Abstract Doc Link 1375538 Disease Relevance 0.47 Pain Relevance 0.39
The low molecular weight antagonist (M(r) = 736) displays nanomolar potency (pA2 = 9.6) in the rabbit vena cava (NK1) bioassay and nanomolar affinity (pKi = 9.1) on the human NK1 receptor expressed by lymphoblastoma cells.
Gene_expression (expressed) of NK1 in NK1 associated with antagonist and potency
10) Confidence 0.71 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8880065 Disease Relevance 0.12 Pain Relevance 0.45
In the genitourinary tract, NK1 receptors are widely distributed in the renal pelvis, ureter, urinary bladder and urethra and mediate smooth muscle contraction and inflammation in response to noxious stimuli.
Gene_expression (distributed) of NK1 in urinary bladder associated with stress incontinence and inflammation
11) Confidence 0.65 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9571643 Disease Relevance 0.96 Pain Relevance 0.48
Immunocytochemical study demonstrated the presence of neuron-specific enolase, Leu 7 antigen, chromogranin, epithelial membrane antigen, and vasoactive intestinal polypeptide within tumor cells.
Gene_expression (presence) of Leu 7 in neuron associated with cancer
12) Confidence 0.65 Published 1986 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 3006628 Disease Relevance 0.60 Pain Relevance 0.08
Lamina 1 projection neurones which express the NK1 receptor (NK1R+) drive a descending serotonergic pathway from the brainstem that enhances spinal dorsal horn neuronal activity via the facilitatory spinal 5-HT3 receptor.
Gene_expression (express) of NK1 in neuronal associated with medulla and spinal dorsal horn
13) Confidence 0.65 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17493751 Disease Relevance 0.15 Pain Relevance 0.35
Thus, a broader panel of immuno-markers may be useful in distinguishing between metastases of malignant melanoma and other metastatic malignancies when the lesion is morphologically undifferentiated; Gupta et al. [15], in fact, reported four cases of morphologically undifferentiated melanoma that showed a positivity for HMB45 (two cases), S100 (one case), vimentin (three cases), NKI/C3 (two cases), NKI/Bteb (one case) and CK (three cases).
Gene_expression (/) of NKI associated with melanoma, carcinoma and metastasis
14) Confidence 0.65 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2396655 Disease Relevance 1.35 Pain Relevance 0
All tumours were negative for CAM 5.2, chromogranin, synaptophysin, Leu 7, neurofilament protein, muscle-specific actin (HHF-35) and desmin (D33).
Neg (negative) Gene_expression (negative) of Leu 7 in muscle associated with cancer
15) Confidence 0.65 Published 1996 Journal Histopathology Section Abstract Doc Link 8872144 Disease Relevance 0.56 Pain Relevance 0.08
Thus, tachykinins acting at NK-1 receptors do not seem to be involved in the histamine response.
Gene_expression (acting) of NK-1
16) Confidence 0.65 Published 1997 Journal Comp. Biochem. Physiol. A Physiol. Section Abstract Doc Link 9366060 Disease Relevance 0.08 Pain Relevance 0.19
Although species variations exist, NK-2 receptors are generally present on the musculature, NK-1 receptors on both neurons and muscles, and NK-3 receptors on neurons only.
Gene_expression (present) of NK-1 in muscles
17) Confidence 0.65 Published 2000 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 11130458 Disease Relevance 0 Pain Relevance 0.20
Thus, a broader panel of immuno-markers may be useful in distinguishing between metastases of malignant melanoma and other metastatic malignancies when the lesion is morphologically undifferentiated; Gupta et al. [15], in fact, reported four cases of morphologically undifferentiated melanoma that showed a positivity for HMB45 (two cases), S100 (one case), vimentin (three cases), NKI/C3 (two cases), NKI/Bteb (one case) and CK (three cases).
Gene_expression (/) of NKI associated with melanoma, carcinoma and metastasis
18) Confidence 0.65 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2396655 Disease Relevance 1.35 Pain Relevance 0
OBJECTIVES: To determine whether substance P (SP, also known as neurokinin 1, NK1) receptors are differentially expressed in bladder biopsies from patients with interstitial cystitis (IC) compared with matched controls.
Gene_expression (expressed) of NK1 in bladder associated with interstitial cystitis and substance p
19) Confidence 0.58 Published 1998 Journal Br J Urol Section Abstract Doc Link 9488063 Disease Relevance 0.17 Pain Relevance 0.26
Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in the human gastrointestinal tract, represent an endogenous modulator system regulating enteric secretomotor functions, inflammatory and immune responses, and visceral hypersensitivity, mainly during pathological gut diseases.
Gene_expression (expressed) of NK1 in gut associated with inflammation, nud and disease
20) Confidence 0.48 Published 2006 Journal Curr Drug Targets Section Abstract Doc Link 16918330 Disease Relevance 0.69 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox