INT85741

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Context Info
Confidence 0.27
First Reported 1999
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.70
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdyn)
Anatomy Link Frequency
spinal cord 2
frontal cortex 2
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 27 100.00 Very High Very High Very High
Spinal cord 4 100.00 Very High Very High Very High
Morphine 10 99.56 Very High Very High Very High
Antinociceptive 6 99.56 Very High Very High Very High
Paracetamol 11 99.06 Very High Very High Very High
Delta-9-tetrahydrocannabinol 6 98.64 Very High Very High Very High
Kappa opioid receptor 3 97.72 Very High Very High Very High
Endogenous opioid 2 95.28 Very High Very High Very High
Opioid 11 93.44 High High
analgesia 1 90.00 High High
Disease Link Frequency Relevance Heat
Spinal Cord Injury 1 100.00 Very High Very High Very High
Injury 1 98.08 Very High Very High Very High
Urological Neuroanatomy 2 97.36 Very High Very High Very High
Toxicity 3 86.80 High High
Nociception 1 82.00 Quite High
Drug Induced Neurotoxicity 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our present results demonstrate that the combination of inactive doses of PARA (100 mg/kg) and morphine (3 mg/kg) is just as effective in decreasing the levels of DYN A as full antinociceptive doses of PARA or morphine alone in the frontal cortex of the rat.
Regulation (effective) of Negative_regulation (decreasing) of DYN in frontal cortex associated with paracetamol, dynorphin, urological neuroanatomy, antinociceptive and morphine
1) Confidence 0.27 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331077 Disease Relevance 0.27 Pain Relevance 2.16
The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene.
Regulation (targeted) of Negative_regulation (inactivation) of Pdyn associated with dynorphin, delta-9-tetrahydrocannabinol and morphine
2) Confidence 0.26 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11717384 Disease Relevance 0 Pain Relevance 0.79
Levels of dynorphin A and a major metabolite, dynorphin A (1-13), increase significantly following spinal cord trauma and reportedly contribute to neurodegeneration associated with secondary injury.
Regulation (contribute) of Negative_regulation (Levels) of dynorphin in spinal cord associated with dynorphin, injury and spinal cord
3) Confidence 0.12 Published 1999 Journal Exp. Neurol. Section Abstract Doc Link 10619553 Disease Relevance 0.43 Pain Relevance 1.20

General Comments

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