INT85743

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Context Info
Confidence 0.32
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.12
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdyn, Oprk1) signal transduction (Oprk1) signal transducer activity (Oprk1)
Pdyn (Mus musculus)
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 72 100.00 Very High Very High Very High
Kappa opioid receptor 53 100.00 Very High Very High Very High
Enkephalin 17 99.88 Very High Very High Very High
analgesia 56 99.40 Very High Very High Very High
Inflammation 65 98.40 Very High Very High Very High
antagonist 25 97.44 Very High Very High Very High
opioid receptor 95 97.20 Very High Very High Very High
Endogenous opioid 39 96.42 Very High Very High Very High
depression 8 94.24 High High
antinociception 37 92.72 High High
Disease Link Frequency Relevance Heat
Stress 63 99.06 Very High Very High Very High
INFLAMMATION 70 98.40 Very High Very High Very High
Toxicity 3 96.00 Very High Very High Very High
Depression 3 94.24 High High
Nociception 9 84.44 Quite High
Drug Induced Neurotoxicity 1 75.00 Quite High
Anxiety Disorder 46 70.48 Quite High
Recurrence 1 58.48 Quite High
Pain 37 51.52 Quite High
Drug Dependence 1 43.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent work has shown that the aversive effects of stress can be mediated by CRF-induced activation of type 2 CRF receptors (CRF2-R) and subsequent activation of kappa opioid receptors (KOR) by dynorphin [1].
dynorphin Positive_regulation (activation) of KOR associated with stress, dynorphin and kappa opioid receptor
1) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 1.08 Pain Relevance 0.60
This provided indirect evidence that dynorphin also stimulates kappa-opioid receptors and suggests that kappa receptor activation may be moderately neuroprotective in the presence of an excitotoxic insult.
dynorphin Positive_regulation (stimulates) of kappa-opioid associated with dynorphin and kappa opioid receptor
2) Confidence 0.11 Published 1999 Journal Exp. Neurol. Section Abstract Doc Link 10619553 Disease Relevance 0.17 Pain Relevance 1.29
The use of antibodies against specific endogenous opioid peptides and selective opioid receptor antagonists reveal that at the early stages of inflammation, the peripheral component of CWS-evoked analgesia is mediated by END, ENK, and DYN, which activate MOR, DOR, and KOR (Machelska et al 2003).
DYN Positive_regulation (activate) of KOR associated with stress, inflammation, antagonist, endogenous opioid, enkephalin, opioid receptor and analgesia
3) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.87 Pain Relevance 1.63

General Comments

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