INT85750

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Context Info
Confidence 0.54
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 7.78
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 2
poly 2
leaf 2
peritoneal macrophages 2
Kupffer cells 2
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 7 99.84 Very High Very High Very High
isoflurane 9 99.00 Very High Very High Very High
Inflammation 65 96.52 Very High Very High Very High
cytokine 117 95.48 Very High Very High Very High
spinal inflammation 1 94.72 High High
rheumatoid arthritis 1 93.76 High High
ischemia 1 90.40 High High
Inflammatory response 13 90.00 High High
Pain management 1 88.20 High High
anesthesia 4 87.04 High High
Disease Link Frequency Relevance Heat
Toxicity 16 99.64 Very High Very High Very High
Targeted Disruption 16 99.20 Very High Very High Very High
Osteoporosis 9 99.04 Very High Very High Very High
Hepatotoxicity 7 97.96 Very High Very High Very High
Apoptosis 35 97.84 Very High Very High Very High
INFLAMMATION 83 96.52 Very High Very High Very High
Inflammatory Bowel Disease 1 96.00 Very High Very High Very High
Low Back Pain 1 94.72 High High
Rheumatoid Arthritis 1 93.76 High High
Poisoning 1 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations suggest that the inhibition of net NO production by SBT leaf extract may be due to its scavenging activity and/or its inhibitory effects on iNOS activation.
Regulation (effects) of Positive_regulation (activation) of iNOS in leaf
1) Confidence 0.54 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16332512 Disease Relevance 0.38 Pain Relevance 0.28
Nitric oxide (NO) is a reactive nitrogen radical produced by activated Kupffer cells via the induction of inducible nitric oxide synthase (iNOS).
Regulation (produced) of Positive_regulation (induction) of iNOS in Kupffer cells
2) Confidence 0.44 Published 2002 Journal Toxicology Section Abstract Doc Link 12049838 Disease Relevance 0.42 Pain Relevance 0.09
Stability of iNOS mRNA is regulated by RNA stabilizing factor, e.g., Hu antigen R (HuR), and RNA destabilizing factors, e.g., AU-rich element/poly(U) binding factor-1 (AUF-1) and tristetraprolin (TTP).
Regulation (regulated) of Positive_regulation (Stability) of iNOS in poly
3) Confidence 0.44 Published 2008 Journal J. Surg. Res. Section Abstract Doc Link 18262561 Disease Relevance 0.43 Pain Relevance 0.46
The aim of this work was to investigate the in vivo effects of endomorphins on nitric oxide release and NOS 2 isoenzyme upregulation in mice peritoneal macrophages additionally challenged ex vivo with lipopolysaccharide.
Spec (investigate) Regulation (effects) of Positive_regulation (upregulation) of NOS 2 in peritoneal macrophages
4) Confidence 0.38 Published 2010 Journal Neuropeptides Section Abstract Doc Link 20004470 Disease Relevance 0.19 Pain Relevance 0.27
The effects of inducible nitric oxide synthase (iNOS)-derived NO in APAP toxicity are known; however, the role of endothelial nitric oxide synthase (eNOS)-derived NO is unknown.
Regulation (effects) of Positive_regulation (inducible) of iNOS associated with toxicity and paracetamol
5) Confidence 0.36 Published 2006 Journal Acad Emerg Med Section Abstract Doc Link 16551773 Disease Relevance 0.55 Pain Relevance 0.59
Inhibitory effects of these drugs on lipopolysaccharide (LPS)-induction of inducible nitric oxide synthase (iNOS) and LPS-stimulated translocation of NficB were determined by use of RAW 264.7 murine macrophages.
Regulation (effects) of Positive_regulation (induction) of iNOS in macrophages
6) Confidence 0.32 Published 2003 Journal Am. J. Vet. Res. Section Body Doc Link 12602591 Disease Relevance 0 Pain Relevance 0
Because isoflurane was used twice, for performance of CLP and then again for cremasteric dissection, the possibility of isoflurane-induced preconditioning, which has been shown to influence microvascular leakage and iNOS induction [37], cannot be excluded.
Regulation (influence) of Positive_regulation (induction) of iNOS associated with isoflurane
7) Confidence 0.24 Published 2007 Journal Crit Care Section Body Doc Link PMC2246221 Disease Relevance 1.04 Pain Relevance 0.49
Our data not only suggest that iNOS activation and increased NO production contribute to the pathogenesis of osteoporosis in these situations, but also suggest that NOS inhibitors could be of therapeutic value in the prevention and treatment of such bone loss.
Regulation (contribute) of Positive_regulation (activation) of iNOS associated with osteoporosis
8) Confidence 0.22 Published 1999 Journal J. Bone Miner. Res. Section Abstract Doc Link 10620073 Disease Relevance 1.39 Pain Relevance 0.36
B activity or on iNOS induction in TNF-?
Regulation (on) of Positive_regulation (induction) of iNOS
9) Confidence 0.15 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.74 Pain Relevance 0.09
As a result of coordinated induction of the iNOS gene by several transcription factors, activated by especially IFN-?
Regulation (result) of Positive_regulation (induction) of iNOS
10) Confidence 0.15 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.36 Pain Relevance 0.08
Such negative regulations of the iNOS gene induction in IFN-?
Regulation (regulations) of Positive_regulation (induction) of iNOS
11) Confidence 0.09 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.28 Pain Relevance 0.11

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