INT85751

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Context Info
Confidence 0.60
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 40
Total Number 40
Disease Relevance 23.53
Pain Relevance 7.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 10
liver 10
microglial cell 8
peritoneum 4
leukocyte 4
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 152 100.00 Very High Very High Very High
Paracetamol 95 100.00 Very High Very High Very High
Morphine 4 100.00 Very High Very High Very High
Inflammation 314 99.98 Very High Very High Very High
Inflammatory response 37 98.92 Very High Very High Very High
Nerve growth factor 5 95.88 Very High Very High Very High
Inflammatory mediators 17 94.28 High High
Substantia nigra 1 91.08 High High
agonist 31 90.40 High High
cINOD 24 87.52 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 212 100.00 Very High Very High Very High
Apoptosis 46 100.00 Very High Very High Very High
INFLAMMATION 377 99.98 Very High Very High Very High
Adhesions 103 99.90 Very High Very High Very High
Influenza Virus Infection 32 99.86 Very High Very High Very High
Disease 123 99.60 Very High Very High Very High
Hepatotoxicity 22 99.44 Very High Very High Very High
Peritonitis 242 99.42 Very High Very High Very High
Adult Respiratory Distress Syndrome 25 99.12 Very High Very High Very High
Drug Induced Neurotoxicity 5 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DHCD potently blocked nuclear factor-kappaB (NF-kappaB) activation, a process necessary for transcriptional activation of iNOS.
Positive_regulation (necessary) of Positive_regulation (activation) of iNOS
1) Confidence 0.60 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14752064 Disease Relevance 0.08 Pain Relevance 0.16
In this paper, we suggest that the influenza virus causes the activation of astrocytes and NOS-2 in the brain.
Positive_regulation (causes) of Positive_regulation (activation) of NOS-2 in brain associated with influenza virus infection
2) Confidence 0.57 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2295255 Disease Relevance 0.93 Pain Relevance 0.06
Immunoblotting studies (Figure 4) demonstrated that LPS-induced peritonitis was associated with a major upregulation of nNOS (155 kD) and eNOS (140 kD), and the induction of iNOS (130 kD) in the peritoneum (Figure 4A).
Positive_regulation (upregulation) of Positive_regulation (induction) of iNOS in peritoneum associated with peritonitis
3) Confidence 0.57 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.47 Pain Relevance 0.04
Additionally, it suppressed induction of inducible nitric oxide synthase (iNOS) in the activated macrophages.
Positive_regulation (induction) of Positive_regulation (inducible) of inducible nitric oxide synthase in macrophages
4) Confidence 0.50 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 18164565 Disease Relevance 0.45 Pain Relevance 0.11
Additionally, it suppressed induction of inducible nitric oxide synthase (iNOS) in the activated macrophages.
Positive_regulation (induction) of Positive_regulation (inducible) of iNOS in macrophages
5) Confidence 0.50 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 18164565 Disease Relevance 0.45 Pain Relevance 0.11
We show in this study that AGEs increase nitric oxide production by induction of the inducible nitric oxide synthase (iNOS) on the mRNA and protein level in the murine microglial cell line N-11.
Positive_regulation (increase) of Positive_regulation (induction) of iNOS in microglial cell
6) Confidence 0.50 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11860491 Disease Relevance 0.46 Pain Relevance 0.07
We show in this study that AGEs increase nitric oxide production by induction of the inducible nitric oxide synthase (iNOS) on the mRNA and protein level in the murine microglial cell line N-11.
Positive_regulation (induction) of Positive_regulation (induction) of iNOS in microglial cell
7) Confidence 0.50 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11860491 Disease Relevance 0.46 Pain Relevance 0.07
Nitric oxide (NO) is a reactive nitrogen radical produced by activated Kupffer cells via the induction of inducible nitric oxide synthase (iNOS).
Positive_regulation (induction) of Positive_regulation (inducible) of iNOS in Kupffer cells
8) Confidence 0.49 Published 2002 Journal Toxicology Section Abstract Doc Link 12049838 Disease Relevance 0.41 Pain Relevance 0.09
Glutathione depletion by DEM or APAP was associated with inhibition of TNF-induced NF-kappaB transactivation of anti-apoptotic genes, including inducible nitric oxide synthase (i-NOS).
Positive_regulation (transactivation) of Positive_regulation (inducible) of inducible nitric oxide synthase associated with paracetamol and apoptosis
9) Confidence 0.45 Published 2003 Journal Hepatology Section Abstract Doc Link 12774022 Disease Relevance 0.87 Pain Relevance 0.33
[Morphine-induced late cardioprotection: potential role of inducible nitric oxide synthase].
Positive_regulation (role) of Positive_regulation (inducible) of inducible nitric oxide synthase associated with morphine
10) Confidence 0.44 Published 2004 Journal Zhonghua Yi Xue Za Zhi Section Title Doc Link 15329271 Disease Relevance 0 Pain Relevance 0.20
[Morphine-induced late cardioprotection: potential role of inducible nitric oxide synthase].
Positive_regulation ([Morphine-induced) of Positive_regulation (role) of inducible nitric oxide synthase associated with morphine
11) Confidence 0.44 Published 2004 Journal Zhonghua Yi Xue Za Zhi Section Title Doc Link 15329271 Disease Relevance 0 Pain Relevance 0.20
Nonetheless, the consistency of the findings with two different methods of attenuating iNOS production bolsters the evidence for the relevance of iNOS induction to vascular leakage.
Positive_regulation (relevance) of Positive_regulation (induction) of iNOS
12) Confidence 0.44 Published 2007 Journal Crit Care Section Body Doc Link PMC2246221 Disease Relevance 0.68 Pain Relevance 0.08
We show in this study that AGEs increase nitric oxide production by induction of the inducible nitric oxide synthase (iNOS) on the mRNA and protein level in the murine microglial cell line N-11.
Positive_regulation (induction) of Positive_regulation (induction) of inducible nitric oxide synthase in microglial cell
13) Confidence 0.44 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11860491 Disease Relevance 0.46 Pain Relevance 0.07
We show in this study that AGEs increase nitric oxide production by induction of the inducible nitric oxide synthase (iNOS) on the mRNA and protein level in the murine microglial cell line N-11.
Positive_regulation (increase) of Positive_regulation (induction) of inducible nitric oxide synthase in microglial cell
14) Confidence 0.44 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11860491 Disease Relevance 0.46 Pain Relevance 0.07
The induction of iNOS by cytokines and proinflammatory agents is known to increase NO production during many inflammatory responses, including peritonitis [12].
Neg (NO) Positive_regulation (increase) of Positive_regulation (induction) of iNOS associated with inflammatory response, peritonitis and cytokine
15) Confidence 0.41 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.66 Pain Relevance 0.25
This may be related to the uneven effect of LPS on the specific NOS regulation: the 2.5-fold increase in eNOS is below the induction of iNOS (normally absent from the peritoneum) and the >10-fold increase in nNOS.
Positive_regulation (increase) of Positive_regulation (induction) of iNOS in peritoneum
16) Confidence 0.41 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.65 Pain Relevance 0.19
The present study indicates that induction of iNOS in the peritoneal membrane is a major mechanism for the increased release of NO metabolites during the early phase of LPS peritonitis.
Positive_regulation (mechanism) of Positive_regulation (induction) of iNOS associated with peritonitis
17) Confidence 0.41 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.72 Pain Relevance 0.21
In particular, LPS bind to their CD14 receptor on the surface of macrophages, resulting in the transcriptional induction of iNOS with subsequent release of NO [35].
Positive_regulation (resulting) of Positive_regulation (induction) of iNOS in macrophages
18) Confidence 0.41 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.77 Pain Relevance 0.26
In the present studies, we used transgenic mice with a targeted disruption of the gene for inducible nitric oxide synthase (NOS II) to analyze the role of nitric oxide in inflammatory mediator production in the liver and in tissue injury induced by acetaminophen.
Positive_regulation (disruption) of Positive_regulation (inducible) of NOS II in liver associated with targeted disruption, paracetamol, inflammation and injury
19) Confidence 0.41 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.02 Pain Relevance 0.43
The main finding of the present study was a disjunction between leukocyte adhesion and vascular leakage; leukocyte rolling and adhesion was increased in septic mice both with and without iNOS induction, but microvascular leakage in septic mice was not increased in the absence of iNOS.
Positive_regulation (increased) of Neg (without) Positive_regulation (induction) of iNOS in leukocyte associated with adhesions
20) Confidence 0.41 Published 2007 Journal Crit Care Section Body Doc Link PMC2246221 Disease Relevance 0.56 Pain Relevance 0

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