INT85761

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Context Info
Confidence 0.30
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.43
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
neurons 2
nerve 2
nucleus 2
hippocampus 2
Chat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 45 99.70 Very High Very High Very High
Hippocampus 15 98.20 Very High Very High Very High
Opioid 2 81.24 Quite High
GABAergic 3 62.00 Quite High
medulla 7 52.96 Quite High
withdrawal 3 50.00 Quite Low
Neuropeptide 3 25.00 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 22 99.90 Very High Very High Very High
Alzheimer's Dementia 22 92.24 High High
Cognitive Disorder 37 89.28 High High
Toxicity 3 86.16 High High
Learning Disorders 2 71.44 Quite High
Dementia 1 69.84 Quite High
Down Syndrome 1 63.56 Quite High
Death 12 50.00 Quite Low
Aging 10 50.00 Quite Low
Vascular Dementia 3 45.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, there were always more cells labeled with p75, suggesting that some cholinergic cells had lost ChAT expression but continued expressing p75 (Figure 1C).
Positive_regulation (lost) of Gene_expression (expression) of ChAT
1) Confidence 0.30 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.13 Pain Relevance 0.10
Unexpectedly, ChAT mRNA was expressed at a lower level in the DMNV than in the hypoglossal nucleus.
Positive_regulation (level) of Gene_expression (expressed) of ChAT mRNA in nucleus
2) Confidence 0.28 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831852 Disease Relevance 0 Pain Relevance 0.03
Activity of choline acetyltransferase, a key enzyme of acetylcholine biosynthesis, is reduced in insulin receptor-positive neurons in Alzheimer's disease and expression of choline acetyltransferase is increased with insulin stimulation [54].
Positive_regulation (increased) of Gene_expression (expression) of choline acetyltransferase in neurons associated with disease
3) Confidence 0.25 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2262060 Disease Relevance 1.17 Pain Relevance 0
One of these components, originally purified from young rat hippocampus, is a novel undecapeptide (hippocampal cholinergic neurostimulating peptide; HCNP); this enhances the production of ChAT, but not of AchE.
Positive_regulation (enhances) of Gene_expression (production) of ChAT in hippocampus associated with hippocampus
4) Confidence 0.24 Published 2000 Journal Prog. Neurobiol. Section Abstract Doc Link 10622376 Disease Relevance 0 Pain Relevance 0.13
This protein was described as hippocampal precursor peptide stimulating cholinergic phenotypes in the developing brain in cooperation with nerve growth factor NGF, where it increases the production of choline acetyltransferase but not acetylcholinesterase [32,33].
Neg (not) Positive_regulation (increases) of Gene_expression (production) of choline acetyltransferase in nerve associated with nerve growth factor
5) Confidence 0.10 Published 2003 Journal Proteome Sci Section Body Doc Link PMC165415 Disease Relevance 0.14 Pain Relevance 0.13

General Comments

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