INT85764

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 4.52
Pain Relevance 7.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PEBP1) mitochondrion (PEBP1) extracellular space (PEBP1)
aging (PEBP1) Golgi apparatus (PEBP1) cytoplasm (PEBP1)
Anatomy Link Frequency
Purkinje cell 1
PEBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 955 99.98 Very High Very High Very High
Opioid 1 99.28 Very High Very High Very High
Catecholamine 18 97.28 Very High Very High Very High
Neurotransmitter 42 92.96 High High
Hippocampus 34 86.68 High High
Pain 6 85.60 High High
opioid receptor 85 82.08 Quite High
gABA 36 80.72 Quite High
Analgesic 13 79.52 Quite High
Dopamine 6 73.80 Quite High
Disease Link Frequency Relevance Heat
Cancer 131 98.20 Very High Very High Very High
Ovarian Cancer 185 98.00 Very High Very High Very High
Death 5 97.76 Very High Very High Very High
Pressure And Volume Under Development 90 95.84 Very High Very High Very High
Stress 13 91.60 High High
Pain 6 85.60 High High
Apoptosis 20 76.20 Quite High
Metastasis 5 60.80 Quite High
Learning Disorders 1 53.28 Quite High
Malignant Neoplastic Disease 5 52.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 21 kDa HCNP precursor protein shows homology with other proteins, and it functions not only as an HCNP precursor, but also as a binding protein for ATP, opioids and phosphatidylethanolamine.
HCNP precursor Binding (binding) of associated with opioid
1) Confidence 0.44 Published 2000 Journal Prog. Neurobiol. Section Abstract Doc Link 10622376 Disease Relevance 0.05 Pain Relevance 0.21
BACKGROUND: The phosphatidylethanolamine-binding protein (PEBP/RKIP), initially found to bind phosphatidylethanolamine (PE), has been shown to be associated with morphine derivatives.
RKIP Binding (bind) of associated with morphine
2) Confidence 0.35 Published 2009 Journal Med. Sci. Monit. Section Abstract Doc Link 19564817 Disease Relevance 0.08 Pain Relevance 0.65
Although we cannot exclude that the presence of PEBP1 in ovarian patient fluids could result from tumor cell death and degradation, altogether our results suggest that additional variants of PEBP1 exist in ovarian cancer patient fluids.
PEBP1 Binding (presence) of associated with cancer, ovarian cancer and death
3) Confidence 0.32 Published 2008 Journal J Transl Med Section Body Doc Link PMC2503970 Disease Relevance 1.19 Pain Relevance 0
The purified rabbit polyclonal antibodies (pAb) from Abgent were raised against synthetic peptides selected from the conserved central PE-binding region of human PEBP1 (center pAb) or from the N-terminal region (N-term pAb).
PEBP1 Binding (binding) of
4) Confidence 0.32 Published 2008 Journal J Transl Med Section Body Doc Link PMC2503970 Disease Relevance 0.30 Pain Relevance 0
A polyclonal antibody directed against the conserved PE-binding sequence of PEBP1 could accurately (p = 0.02) discriminate between ovarian cancer and control sera on antibody arrays.
PEBP1 Binding (binding) of associated with ovarian cancer
5) Confidence 0.32 Published 2008 Journal J Transl Med Section Body Doc Link PMC2503970 Disease Relevance 0.83 Pain Relevance 0
This analysis generated preferential binding of anti-PEBP1 antibody to case serum with a p-value of 0.02, demonstrating that the presence of PEBP1 in serum is able to differentiate ovarian carcinoma from control sera.
PEBP1 Binding (binding) of associated with ovarian cancer
6) Confidence 0.32 Published 2008 Journal J Transl Med Section Body Doc Link PMC2503970 Disease Relevance 0.98 Pain Relevance 0
Finally, in the 2-D gels (spot indicated in Figure 3D, apparent molecular weight of 22 kDa) we identified two unique peptides KLYTLVLTDP DAPSR and KGNDISSGTVLSDYVGSGPPK that were found by peptide prophet to map in the central PE-binding region of the protein PEBP1 with a probability 0.999 and 0.983, respectively.
PEBP1 Binding (binding) of
7) Confidence 0.32 Published 2008 Journal J Transl Med Section Body Doc Link PMC2503970 Disease Relevance 0 Pain Relevance 0
In chromaffin granules, M6G is bound to the intragranular phosphatidylethanolamine-binding protein (PEBP or Raf kinase inhibitor protein) [13], which also binds morphine [14].
intragranular phosphatidylethanolamine-binding protein Binding (binds) of associated with morphine
8) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2265639 Disease Relevance 0.26 Pain Relevance 1.12
Whether morphine is secreted in a complex with PEBP remains an open question.


PEBP Binding (complex) of associated with morphine
9) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2265639 Disease Relevance 0.05 Pain Relevance 1.31
In chromaffin granules, M6G is bound to the intragranular phosphatidylethanolamine-binding protein (PEBP or Raf kinase inhibitor protein) [13], which also binds morphine [14].
intragranular phosphatidylethanolamine-binding protein Binding (bound) of associated with morphine
10) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2265639 Disease Relevance 0.25 Pain Relevance 1.05
In chromaffin granules, M6G is bound to the intragranular phosphatidylethanolamine-binding protein (PEBP or Raf kinase inhibitor protein) [13], which also binds morphine [14].
Raf kinase Binding (binds) of associated with morphine
11) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2265639 Disease Relevance 0.26 Pain Relevance 1.09
In chromaffin granules, M6G is bound to the intragranular phosphatidylethanolamine-binding protein (PEBP or Raf kinase inhibitor protein) [13], which also binds morphine [14].
PEBP Binding (binds) of associated with morphine
12) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2265639 Disease Relevance 0.26 Pain Relevance 1.10
In parallel, the immunoreactivity of the morphine-binding protein PEBP [14] was found in basket cell nerve termini around Purkinje cell bodies (Fig. 7D, arrow), suggesting the presence of a morphine-PEBP complex in these structures.
PEBP Binding (binding) of in Purkinje cell associated with morphine
13) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2265639 Disease Relevance 0 Pain Relevance 0.67

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