INT85766

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 19
Total Number 22
Disease Relevance 6.82
Pain Relevance 8.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn11a) transmembrane transport (Scn11a)
Anatomy Link Frequency
neurons 4
trigeminal ganglia 3
dorsal root ganglion 3
ovary 3
spinal cord 1
Scn11a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 45 100.00 Very High Very High Very High
Nav1.9 3 100.00 Very High Very High Very High
nav1.8 3 100.00 Very High Very High Very High
trigeminal ganglion 4 99.84 Very High Very High Very High
dorsal root ganglion 59 99.60 Very High Very High Very High
tetrodotoxin 14 99.16 Very High Very High Very High
Sciatic nerve 27 99.04 Very High Very High Very High
c fibre 6 98.60 Very High Very High Very High
Neuropathic pain 3 98.28 Very High Very High Very High
addiction 6 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 11 99.84 Very High Very High Very High
Ganglion Cysts 69 99.60 Very High Very High Very High
Injury 15 99.16 Very High Very High Very High
Neuropathic Pain 5 98.28 Very High Very High Very High
Nervous System Injury 13 95.00 High High
Adhesions 4 87.76 High High
Facial Pain 3 87.36 High High
Pain 1 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Expression of PN3 and NaN in trigeminal ganglion during occlusal trauma in rat].
Gene_expression (Expression) of NaN in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion and injury
1) Confidence 0.78 Published 2004 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Title Doc Link 15498355 Disease Relevance 0.20 Pain Relevance 0.19
While rat NaN/SNS2 has been reported to be expressed specifically in the peripheral sensory neurons, NaT/Scn11a is expressed not only in the peripheral sensory neurons but also in the spinal cord, uterus, testis, ovary, placenta, and small intestine.
Gene_expression (expressed) of NaN in uterus associated with spinal cord
2) Confidence 0.75 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623609 Disease Relevance 0 Pain Relevance 0.28
SCN11A encodes the tetrodotoxin-resistant (TTX-R) sodium channel Nav1.9a/NaN, which is preferentially expressed in nociceptive primary sensory neurons of dorsal root ganglia (DRG) and trigeminal ganglia.
Gene_expression (expressed) of NaN in trigeminal ganglia associated with nociception, tetrodotoxin and sodium channel
3) Confidence 0.75 Published 2002 Journal Mol. Neurobiol. Section Abstract Doc Link 12428758 Disease Relevance 0.18 Pain Relevance 0.30
RESULTS: In groups, including control, occlusal trauma groups, PN(3) mRNA and NaN mRNA were all expressed in trigeminal ganglion neurons.
Gene_expression (expressed) of NaN mRNA in neurons
4) Confidence 0.60 Published 2004 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Body Doc Link 15498355 Disease Relevance 0.18 Pain Relevance 0
CONCLUSIONS: The stimulation of occlusal trauma upregulates expressions of PN(3) mRNA and NaN mRNA, which suggests the signal occurring and conduction of chronic pain by occlusal trauma have the same molecular mechanism of sodium channel as inflammatory pain.


Gene_expression (expressions) of NaN mRNA
5) Confidence 0.60 Published 2004 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Body Doc Link 15498355 Disease Relevance 0.15 Pain Relevance 0
These results indicate that peripheral, but not central, axotomy results in a reduction in expression of functional SNS and NaN channels in c-type DRG neurons and suggest a basis for the altered electrical properties that are observed after peripheral nerve injury.
Gene_expression (expression) of NaN in peripheral nerve associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
6) Confidence 0.59 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11007885 Disease Relevance 0.83 Pain Relevance 0.55
However, it is not known whether changes in the currents associated with SNS and NaN or in the expression of SNS and NaN channel protein occur after axotomy of the peripheral projections of DRG neurons or whether similar changes occur after transection of the central (dorsal root) projections of DRG neurons.
Gene_expression (expression) of NaN in neurons associated with dorsal root ganglion
7) Confidence 0.59 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11007885 Disease Relevance 0.81 Pain Relevance 0.65
Levels of SNS and NaN protein in the two types of injuries were paralleled by their respective TTX-resistant currents.
Gene_expression (Levels) of NaN protein associated with injury
8) Confidence 0.59 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11007885 Disease Relevance 0.89 Pain Relevance 0.70
We have now investigated changes in the expression of the TTX-resistant VGSCs, Nav1.8 (SNS/PN3) and Nav1.9 (SNS2/NaN) by immunohistochemistry in rat models of neuropathic pain both with an intermingling of intact and degenerated axons in the nerve stump (SNL and CCI) and with a co-mingling in the same DRG of neurons with injured and uninjured axons (sciatic axotomy and SNI).
Spec (investigated) Gene_expression (expression) of NaN in SNI associated with dorsal root ganglion, eae, neuropathic pain, sciatic nerve, nav1.8 and nav1.9
9) Confidence 0.58 Published 2002 Journal Pain Section Abstract Doc Link 11972999 Disease Relevance 1.03 Pain Relevance 1.39
Two TTX-resistant sodium channels, SNS and NaN, are preferentially expressed in c-type dorsal root ganglion (DRG) neurons and have been shown recently to have distinct electrophysiological signatures, SNS producing a slowly inactivating and NaN producing a persistent sodium current with a relatively hyperpolarized voltage-dependence.
Gene_expression (expressed) of NaN in dorsal root ganglion associated with ganglion cysts, addiction, dorsal root ganglion and sodium channel
10) Confidence 0.52 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11007885 Disease Relevance 0.48 Pain Relevance 0.44
Two TTX-resistant sodium channels, SNS and NaN, are preferentially expressed in c-type dorsal root ganglion (DRG) neurons and have been shown recently to have distinct electrophysiological signatures, SNS producing a slowly inactivating and NaN producing a persistent sodium current with a relatively hyperpolarized voltage-dependence.
Gene_expression (producing) of NaN in neurons associated with ganglion cysts, addiction, dorsal root ganglion and sodium channel
11) Confidence 0.46 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11007885 Disease Relevance 0.62 Pain Relevance 0.55
Two TTX-resistant sodium channels, SNS and NaN, are preferentially expressed in c-type dorsal root ganglion (DRG) neurons and have been shown recently to have distinct electrophysiological signatures, SNS producing a slowly inactivating and NaN producing a persistent sodium current with a relatively hyperpolarized voltage-dependence.
Gene_expression (producing) of NaN in dorsal root ganglion associated with ganglion cysts, addiction, dorsal root ganglion and sodium channel
12) Confidence 0.46 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11007885 Disease Relevance 0.61 Pain Relevance 0.52
This is the first examination of sensory receptive properties and associated electrophysiological properties in vivo of dorsal root ganglion (DRG) neurons that express the TTX-resistant sodium channel Na(v)1.9 (NaN).
Gene_expression (express) of NaN in neurons associated with ganglion cysts, dorsal root ganglion and sodium channel
13) Confidence 0.37 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12196564 Disease Relevance 0.52 Pain Relevance 0.29
While rat NaN/SNS2 has been reported to be expressed specifically in the peripheral sensory neurons, NaT/Scn11a is expressed not only in the peripheral sensory neurons but also in the spinal cord, uterus, testis, ovary, placenta, and small intestine.
Gene_expression (expressed) of NaN in placenta associated with spinal cord
14) Confidence 0.26 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623609 Disease Relevance 0 Pain Relevance 0.28
While rat NaN/SNS2 has been reported to be expressed specifically in the peripheral sensory neurons, NaT/Scn11a is expressed not only in the peripheral sensory neurons but also in the spinal cord, uterus, testis, ovary, placenta, and small intestine.
Gene_expression (expressed) of NaN in small intestine associated with spinal cord
15) Confidence 0.26 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623609 Disease Relevance 0 Pain Relevance 0.28
While rat NaN/SNS2 has been reported to be expressed specifically in the peripheral sensory neurons, NaT/Scn11a is expressed not only in the peripheral sensory neurons but also in the spinal cord, uterus, testis, ovary, placenta, and small intestine.
Gene_expression (expressed) of NaN in ovary associated with spinal cord
16) Confidence 0.26 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623609 Disease Relevance 0 Pain Relevance 0.28
While rat NaN/SNS2 has been reported to be expressed specifically in the peripheral sensory neurons, NaT/Scn11a is expressed not only in the peripheral sensory neurons but also in the spinal cord, uterus, testis, ovary, placenta, and small intestine.
Gene_expression (expressed) of NaN in spinal cord associated with spinal cord
17) Confidence 0.26 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623609 Disease Relevance 0 Pain Relevance 0.28
While rat NaN/SNS2 has been reported to be expressed specifically in the peripheral sensory neurons, NaT/Scn11a is expressed not only in the peripheral sensory neurons but also in the spinal cord, uterus, testis, ovary, placenta, and small intestine.
Gene_expression (expressed) of NaN in testis associated with spinal cord
18) Confidence 0.26 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623609 Disease Relevance 0 Pain Relevance 0.28
Co-transfection of Chinese hamster ovary cells with Na(v)1.9/NaN and contactin enhances the surface expression of the sodium channel over that of Na(v)1.9/NaN alone.
Gene_expression (Co-transfection) of NaN in ovary associated with sodium channel
19) Confidence 0.12 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11581273 Disease Relevance 0.09 Pain Relevance 0.26
To examine this issue we studied the voltage-gated sodium channel Na(v)1.9/NaN, which is preferentially expressed in small sensory neurons of dorsal root ganglia and trigeminal ganglia and the nonmyelinated axons that arise from them.
Gene_expression (expressed) of NaN in trigeminal ganglia associated with sodium channel
20) Confidence 0.10 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11581273 Disease Relevance 0.09 Pain Relevance 0.22

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