INT85777

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Context Info
Confidence 0.46
First Reported 1999
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 1.85
Pain Relevance 5.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
ventricle 2
spinal nerves 2
VLM 2
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 67 100.00 Very High Very High Very High
Brush evoked pain 5 99.52 Very High Very High Very High
Morphine 117 99.04 Very High Very High Very High
noradrenaline 5 96.72 Very High Very High Very High
nMDA receptor 86 96.44 Very High Very High Very High
Pain 167 96.40 Very High Very High Very High
Arthritis 86 96.20 Very High Very High Very High
chung model 1 96.20 Very High Very High Very High
medulla 15 96.00 Very High Very High Very High
amygdala 194 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 26 99.52 Very High Very High Very High
Pain 167 96.40 Very High Very High Very High
Arthritis 126 96.20 Very High Very High Very High
Toxocariasis 5 96.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 87.72 High High
Opiate Addiction 3 75.84 Quite High
Nervous System Injury 14 75.00 Quite High
Low Back Pain 5 69.12 Quite High
Ganglion Cysts 44 50.00 Quite Low
Hyperalgesia 16 44.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated whether cAMP-dependent protein kinase (PKA) plays a role in this process by estimating changes in PKA immunoreactivity and the influence of inhibition of PKA on Fos protein expression and tyrosine hydroxylase (TH) immunoreactivity levels in the PVN and NTS/VLM during morphine withdrawal.
Regulation (influence) of Negative_regulation (inhibition) of PKA in VLM associated with medulla, withdrawal and morphine
1) Confidence 0.46 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15663473 Disease Relevance 0.43 Pain Relevance 1.30
We investigated whether cAMP-dependent protein kinase (PKA) plays a role in this process by estimating changes in PKA immunoreactivity and the influence of inhibitor of PKA on Fos protein expression, tyrosine hydroxylase (TH) immunoreactivity levels and NA turnover in the left and right ventricle.
Regulation (influence) of Negative_regulation (inhibitor) of PKA in ventricle associated with noradrenaline
2) Confidence 0.40 Published 2007 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 17216288 Disease Relevance 0.16 Pain Relevance 1.07
The additive effect of PKA and ERK inhibitors suggest that PKA and ERK do not simply act in a serial arrangement in which one inhibitor would occlude the effect of the other.
Regulation (effect) of Negative_regulation (inhibitors) of PKA
3) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.22 Pain Relevance 0.19
PKA and ERK inhibitors selectively affect synaptic plasticity but not normal transmission (Figures 2, 3, 4) and can phosphorylate NMDA receptors [41-43].
Neg (not) Regulation (affect) of Negative_regulation (inhibitors) of PKA associated with nmda receptor
4) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.47 Pain Relevance 0.68
We investigated the effects of inhibiting spinal protein kinases including PKC, PKA and PKG on tactile allodynia in rats with a unilateral tight ligation on L5/L6 spinal nerves (Chung model).
Spec (investigated) Regulation (effects) of Spec (investigated) Negative_regulation (inhibiting) of PKA in spinal nerves associated with brush evoked pain and chung model
5) Confidence 0.17 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10624801 Disease Relevance 0.38 Pain Relevance 0.36
Although non-specific effects of these PKA and PKC inhibitors cannot be completely ruled out, these data indicate a likely upregulated PKC and PKA activity, which is at least partially responsible for the enhanced glutamate synaptic transmission in NRM secondary cells from morphine-tolerant rats.


Regulation (effects) of Negative_regulation (inhibitors) of PKA associated with raphe magnus, glutamate, kinase c and morphine
6) Confidence 0.16 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074357 Disease Relevance 0.19 Pain Relevance 1.96
To confirm the conclusion, we studied the effect of a specific membrane impermeant PKA inhibitor, PKA-I, on the PGE2 action (Fig. 5B).
Regulation (effect) of Negative_regulation (inhibitor) of PKA
7) Confidence 0.11 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0 Pain Relevance 0
To confirm the conclusion, we studied the effect of a specific membrane impermeant PKA inhibitor, PKA-I, on the PGE2 action (Fig. 5B).
Regulation (effect) of Negative_regulation (inhibitor) of PKA
8) Confidence 0.08 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0 Pain Relevance 0
RcAMP, a selective PKA inhibitor, was also ineffective in these experimental conditions (Figure 4b).
Regulation (ineffective) of Negative_regulation (inhibitor) of PKA
9) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.19

General Comments

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