INT85780

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Context Info
Confidence 0.29
First Reported 1999
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.47
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Prkaca, Prkcg) cytosol (Prkaca, Prkcg) nucleus (Prkaca, Prkcg)
plasma membrane (Prkaca, Prkcg) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Anatomy Link Frequency
spinal nerves 1
dorsal horn 1
Prkaca (Rattus norvegicus)
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 19 100.00 Very High Very High Very High
Brush evoked pain 4 99.52 Very High Very High Very High
Dorsal horn 1 98.94 Very High Very High Very High
qutenza 29 97.34 Very High Very High Very High
chung model 1 96.20 Very High Very High Very High
intrathecal 7 90.96 High High
Spinal cord 15 50.08 Quite High
Pain 6 25.00 Low Low
central sensitization 13 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 5 99.52 Very High Very High Very High
Nociception 17 85.12 High High
Nervous System Injury 3 75.00 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the effects of inhibiting spinal protein kinases including PKC, PKA and PKG on tactile allodynia in rats with a unilateral tight ligation on L5/L6 spinal nerves (Chung model).
PKA Spec (investigated) Regulation (effects) of PKC in spinal nerves associated with brush evoked pain and chung model
1) Confidence 0.29 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10624801 Disease Relevance 0.38 Pain Relevance 0.36
The major findings in the current study demonstrated that intradermal capsaicin injection causes an increase in Ser-133 CREB phosphorylation in the dorsal horn and that the enhancement of CREB phosphorylation is regulated by the activity of MAP kinase, PKA and PKC.
PKA Regulation (regulated) of PKC in dorsal horn associated with kinase c, qutenza and dorsal horn
2) Confidence 0.04 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.09 Pain Relevance 0.81

General Comments

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