INT85783

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.09
First Reported 1999
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.38
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKG1, Prkcg) plasma membrane (PRKG1, Prkcg) cytoplasm (PRKG1, Prkcg)
signal transduction (PRKG1) nucleus (Prkcg) intracellular (Prkcg)
Anatomy Link Frequency
spinal nerves 1
neurons 1
PRKG1 (Homo sapiens)
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Brush evoked pain 4 99.84 Very High Very High Very High
Dorsal horn neuron 40 99.28 Very High Very High Very High
nMDA receptor 4 97.92 Very High Very High Very High
chung model 1 96.52 Very High Very High Very High
central sensitization 37 95.48 Very High Very High Very High
qutenza 64 92.32 High High
intrathecal 1 91.60 High High
Kinase C 1 75.00 Quite High
Spinal cord 15 72.36 Quite High
Dorsal horn 7 71.60 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 10 99.84 Very High Very High Very High
Nervous System Injury 2 75.00 Quite High
Pain 1 27.52 Quite Low
Nociception 24 10.56 Low Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 1 5.00 Very Low Very Low Very Low
Obesity 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Inflammatory Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the effects of inhibiting spinal protein kinases including PKC, PKA and PKG on tactile allodynia in rats with a unilateral tight ligation on L5/L6 spinal nerves (Chung model).
PKG Spec (investigated) Regulation (effects) of PKC in spinal nerves associated with brush evoked pain and chung model
1) Confidence 0.09 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10624801 Disease Relevance 0.38 Pain Relevance 0.37
It is known that several protein kinases, such as PKC, PKA, PKG, MAPK and CaMKII, affect the responses of dorsal horn neurons through phosphorylation of synaptic receptors and proteins involved in the intracellular signal transduction pathways, and the consequences of this modulation could be central sensitization, long-lasting inhibition, and/or changes in gene expression [23-31,53,54].
PKG Regulation (affect) of PKC in neurons associated with central sensitization and dorsal horn neuron
2) Confidence 0.02 Published 2006 Journal Mol Pain Section Body Doc Link PMC1559591 Disease Relevance 0 Pain Relevance 0.53

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox