INT85787

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Context Info
Confidence 0.53
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.77
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prlh) lipid metabolic process (Prlh) cytoplasm (Prlh)
Anatomy Link Frequency
lactotrophs 3
area postrema 1
nucleus 1
medulla oblongata 1
Prlh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 10 99.96 Very High Very High Very High
Central nervous system 2 99.92 Very High Very High Very High
Pain 14 95.64 Very High Very High Very High
antiallodynic 2 92.72 High High
Dorsal horn 2 92.48 High High
antinociception 2 91.28 High High
Spinal cord 2 90.96 High High
fifth nerve 2 87.92 High High
intrathecal 2 84.16 Quite High
anesthesia 1 82.32 Quite High
Disease Link Frequency Relevance Heat
Pain 10 95.64 Very High Very High Very High
Neuropathic Pain 8 93.60 High High
INFLAMMATION 86 80.72 Quite High
Nociception 2 68.16 Quite High
Stress 144 5.00 Very Low Very Low Very Low
Cancer 66 5.00 Very Low Very Low Very Low
Targeted Disruption 66 5.00 Very Low Very Low Very Low
Pituitary Cancer 33 5.00 Very Low Very Low Very Low
Starvation 30 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the medulla, PrRP receptor mRNA expression was abundant only in area postrema.
Transcription (expression) of PrRP in area postrema associated with medulla
1) Confidence 0.53 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975697 Disease Relevance 0.87 Pain Relevance 1.11
PrRP and NPFF mRNA were expressed in different parts of the nucleus of the solitary tract.
Transcription (expressed) of PrRP in nucleus
2) Confidence 0.53 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975697 Disease Relevance 0.90 Pain Relevance 1.12
PrRP mRNA levels in the medulla oblongata were decreased by ovariectomy and increased by estrogen treatment.
Transcription (levels) of PrRP in medulla oblongata associated with medulla
3) Confidence 0.49 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10624802 Disease Relevance 0 Pain Relevance 0.25
In both intact pituitary and aggregates, we recently found PrRP mRNA and PrRP-like immunoreactivity, particularly in gonadotrophs associated with cup-shaped lactotrophs (Swinnen and Denef, unpublished observations).
Transcription (found) of PrRP in lactotrophs
4) Confidence 0.22 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.07
In both intact pituitary and aggregates, we recently found PrRP mRNA and PrRP-like immunoreactivity, particularly in gonadotrophs associated with cup-shaped lactotrophs (Swinnen and Denef, unpublished observations).
Transcription (immunoreactivity) of PrRP-like in lactotrophs
5) Confidence 0.22 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.07
In both intact pituitary and aggregates, we recently found PrRP mRNA and PrRP-like immunoreactivity, particularly in gonadotrophs associated with cup-shaped lactotrophs (Swinnen and Denef, unpublished observations).
Transcription (immunoreactivity) of PrRP in lactotrophs
6) Confidence 0.22 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.07

General Comments

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