INT85788

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Context Info
Confidence 0.54
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.95
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prlh) lipid metabolic process (Prlh) cytoplasm (Prlh)
Anatomy Link Frequency
PRh 2
medulla oblongata 2
Prlh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 6 100.00 Very High Very High Very High
lidocaine 8 99.56 Very High Very High Very High
Potency 2 90.88 High High
anesthesia 2 82.32 Quite High
Hippocampus 6 34.76 Quite Low
amygdala 1 27.08 Quite Low
Neuropeptide 6 25.00 Low Low
Analgesic 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 33 98.12 Very High Very High Very High
Frailty 1 44.60 Quite Low
Pain 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PrRP mRNA levels in the medulla oblongata were decreased by ovariectomy and increased by estrogen treatment.
Negative_regulation (decreased) of PrRP in medulla oblongata associated with medulla
1) Confidence 0.54 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10624802 Disease Relevance 0 Pain Relevance 0.25
Finally, PRh inactivation immediately and 20 min after the sample phase, but not 40, 60, or 80 min after, also disrupted subsequent object recognition when the retention delay was sufficiently long to ensure the dissipation of the actions of lidocaine during the choice phase.
Negative_regulation (inactivation) of PRh in PRh associated with cognitive disorder and lidocaine
2) Confidence 0.43 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15634766 Disease Relevance 0.51 Pain Relevance 0.36
The data indicate that estrogen is prerequisite to the stimulatory effect of PrRP on the secretion of prolactin and to the increase of PrRP mRNA levels in the medulla oblongata.
Negative_regulation (effect) of PrRP in medulla oblongata associated with medulla
3) Confidence 0.39 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10624802 Disease Relevance 0 Pain Relevance 0.25
In a series of experiments, transient inactivation of PRh was accomplished with bilateral infusions of lidocaine directly into PRh immediately before the sample phase (encoding), immediately before the choice phase (retrieval), or within the retention delay after the sample phase (storage-consolidation).
Negative_regulation (inactivation) of PRh in PRh associated with lidocaine
4) Confidence 0.38 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15634766 Disease Relevance 0.44 Pain Relevance 0.22
There was no evidence that the PRh group was impaired on performing the cross versus circle discrimination when it was tested concurrently (Stages 1–7) with the three structural discriminations (U = 25.5, p = .28).


Negative_regulation (impaired) of PRh
5) Confidence 0.35 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC2834571 Disease Relevance 0 Pain Relevance 0

General Comments

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