INT85789

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Context Info
Confidence 0.78
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 17
Disease Relevance 4.50
Pain Relevance 5.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prlh) lipid metabolic process (Prlh) cytoplasm (Prlh)
Anatomy Link Frequency
brain 2
lactotrophs 2
area postrema 1
neuronal 1
Stage 5 1
Prlh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 23 100.00 Very High Very High Very High
medulla 15 99.96 Very High Very High Very High
Central nervous system 5 99.92 Very High Very High Very High
Pain 46 98.88 Very High Very High Very High
fifth nerve 5 96.36 Very High Very High Very High
Spinal cord 5 94.64 High High
Dorsal horn 5 93.88 High High
Inflammation 59 93.12 High High
antiallodynic 5 92.72 High High
Neuropathic pain 5 91.76 High High
Disease Link Frequency Relevance Heat
Pain 35 98.88 Very High Very High Very High
Neuropathic Pain 20 93.60 High High
INFLAMMATION 61 93.12 High High
Nociception 5 90.64 High High
Cognitive Disorder 152 60.72 Quite High
Frailty 8 44.60 Quite Low
Stress 96 5.00 Very Low Very Low Very Low
Cancer 44 5.00 Very Low Very Low Very Low
Targeted Disruption 44 5.00 Very Low Very Low Very Low
Pituitary Cancer 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Even if the neuronal groups producing NPFF and PrRP were distinct, the fiber networks immunoreactive for PrRP and NPFF overlapped.
Gene_expression (producing) of PrRP in neuronal
1) Confidence 0.78 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975697 Disease Relevance 0.80 Pain Relevance 1.01
The prolactin-releasing activity of the peptide and the expression of the PrRP gene were examined in vivo in relation to estrogen status.
Gene_expression (expression) of PrRP
2) Confidence 0.71 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10624802 Disease Relevance 0 Pain Relevance 0.12
Prolactin-releasing peptide (PrRP) and neuropeptide FF (NPFF) are RF-amide peptides expressed in brain areas involved in pain modulation.
Gene_expression (expressed) of Prolactin-releasing in brain associated with pain and neuropeptide
3) Confidence 0.67 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975697 Disease Relevance 0.81 Pain Relevance 0.88
Prolactin-releasing peptide (PrRP) and neuropeptide FF (NPFF) are RF-amide peptides expressed in brain areas involved in pain modulation.
Gene_expression (expressed) of PrRP in brain associated with pain and neuropeptide
4) Confidence 0.67 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975697 Disease Relevance 0.81 Pain Relevance 0.88
PrRP and NPFF mRNA were expressed in different parts of the nucleus of the solitary tract.
Gene_expression (expressed) of PrRP in nucleus
5) Confidence 0.67 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975697 Disease Relevance 0.90 Pain Relevance 1.12
In the medulla, PrRP receptor mRNA expression was abundant only in area postrema.
Gene_expression (expression) of PrRP in area postrema associated with medulla
6) Confidence 0.67 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975697 Disease Relevance 0.87 Pain Relevance 1.11
There was no evidence of a difference in performance between the ShamPRh and PRh groups (F < 1) or any interaction (F < 1).
Gene_expression (groups) of PRh
7) Confidence 0.55 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC2834571 Disease Relevance 0.06 Pain Relevance 0
Furthermore, the scores of the Sham and PRh groups did not differ from one another, t(14) = 1.34, p = .103 (one-tailed).
Gene_expression (groups) of PRh
8) Confidence 0.55 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC2834571 Disease Relevance 0 Pain Relevance 0
There was no evidence of a difference in performance between the ShamPRh and PRh groups (F < 1) or any interaction (F < 1).
Gene_expression (groups) of ShamPRh
9) Confidence 0.55 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC2834571 Disease Relevance 0.06 Pain Relevance 0
W–) were made only between the PRh group and the ShamPRh group (the better performing control group).
Gene_expression (group) of PRh
10) Confidence 0.55 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC2834571 Disease Relevance 0 Pain Relevance 0
There was no evidence that the PRh group was impaired on performing the cross versus circle discrimination when it was tested concurrently (Stages 1–7) with the three structural discriminations (U = 25.5, p = .28).


Gene_expression (group) of PRh
11) Confidence 0.55 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC2834571 Disease Relevance 0 Pain Relevance 0
The same lack of difference was found when only the PRh and ShamPRh groups were compared on this measure (t < 1).
Gene_expression (compared) of PRh
12) Confidence 0.55 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC2834571 Disease Relevance 0 Pain Relevance 0
The same pattern was found for Stage 5, where the PRh group did not differ from either the Sham or the ShamPRh group, highest F(1, 14) = 3.05, p = .1.
Gene_expression (group) of PRh in Stage 5
13) Confidence 0.55 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC2834571 Disease Relevance 0 Pain Relevance 0
There was a significant correlation between basal levels of PRLH and breast turgency at every examination.
Gene_expression (levels) of PRLH
14) Confidence 0.36 Published 1977 Journal Acta Ginecol (Madr) Section Abstract Doc Link 12326820 Disease Relevance 0.19 Pain Relevance 0.19
The same lack of difference was found when only the PRh and ShamPRh groups were compared on this measure (t < 1).
Gene_expression (compared) of ShamPRh
15) Confidence 0.24 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC2834571 Disease Relevance 0 Pain Relevance 0
In both intact pituitary and aggregates, we recently found PrRP mRNA and PrRP-like immunoreactivity, particularly in gonadotrophs associated with cup-shaped lactotrophs (Swinnen and Denef, unpublished observations).
Gene_expression (immunoreactivity) of PrRP-like in lactotrophs
16) Confidence 0.21 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.07
In both intact pituitary and aggregates, we recently found PrRP mRNA and PrRP-like immunoreactivity, particularly in gonadotrophs associated with cup-shaped lactotrophs (Swinnen and Denef, unpublished observations).
Gene_expression (immunoreactivity) of PrRP in lactotrophs
17) Confidence 0.21 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.07

General Comments

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