INT8580

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Context Info
Confidence 0.75
First Reported 1982
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 132
Total Number 136
Disease Relevance 62.98
Pain Relevance 21.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
neutrophil 29
chondrocytes 5
granulocyte 4
lung 3
liver 3
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1285 100.00 Very High Very High Very High
rheumatoid arthritis 669 100.00 Very High Very High Very High
chemokine 591 100.00 Very High Very High Very High
cytokine 429 99.96 Very High Very High Very High
Osteoarthritis 614 99.84 Very High Very High Very High
Dopamine 98 99.80 Very High Very High Very High
opioid receptor 42 99.78 Very High Very High Very High
metalloproteinase 130 99.64 Very High Very High Very High
Enkephalin 16 99.54 Very High Very High Very High
cva 72 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1487 100.00 Very High Very High Very High
Rheumatoid Arthritis 669 100.00 Very High Very High Very High
Infection 255 100.00 Very High Very High Very High
Emphysema 215 100.00 Very High Very High Very High
Toxicity 88 100.00 Very High Very High Very High
Shock 183 99.88 Very High Very High Very High
Osteoarthritis 606 99.84 Very High Very High Very High
Lymphatic System Cancer 150 99.84 Very High Very High Very High
Systemic Lupus Erythematosus 67 99.84 Very High Very High Very High
Apoptosis 651 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the RT-PCR analysis, Kv1.1, Kv4.2, Kv1.4, Kir2.1, heag1, MaxiK, hNE-Na, and TWIK-1 were detected.
Gene_expression (detected) of hNE
1) Confidence 0.75 Published 2007 Journal Stem Cells Section Abstract Doc Link 17525238 Disease Relevance 0 Pain Relevance 0.10
Other proteins, connected to expression and transportation of human neutrophil elastase, have also been linked to SCN disease.
Gene_expression (expression) of elastase in neutrophil associated with disease and neutrophil disorders
2) Confidence 0.67 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.84 Pain Relevance 0
Western blot analysis of human neutrophil elastase expression was performed twice.


Gene_expression (expression) of elastase in neutrophil
3) Confidence 0.67 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0 Pain Relevance 0
No causative ELA2 mutations were found, and therapeutic concentrations of sulphasalazine did not increase the expression of human neutrophil elastase.
Gene_expression (expression) of elastase in neutrophil
4) Confidence 0.67 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.58 Pain Relevance 0
When G-CSF is exposed to active elastase enzyme in vitro, G-CSF is rapidly cleaved and rendered inactive [11].
Gene_expression (exposed) of elastase enzyme
5) Confidence 0.67 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.96 Pain Relevance 0
causes accumulation of canine neutrophil elastase in the cytosolic compartments [12], and mutations in ELA2 may disrupt the AP3?
Gene_expression (mutations) of ELA2 in neutrophil
6) Confidence 0.67 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.50 Pain Relevance 0
Twelve of 19 patients with pancreatic cancer had abnormal serum elastase levels; this was especially true in patients with cancer of the pancreatic head.
Gene_expression (levels) of elastase in head associated with cancer and pancreatic cancer
7) Confidence 0.63 Published 1982 Journal Am. J. Surg. Section Abstract Doc Link 6179433 Disease Relevance 0.81 Pain Relevance 0.09
Values <250 ng/ml were regarded as decreased elastase levels.
Gene_expression (levels) of elastase
8) Confidence 0.62 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2778713 Disease Relevance 0.73 Pain Relevance 0.21
Plasma levels of elastase were also measured by an immunoenzymatic method.
Gene_expression (levels) of elastase in Plasma
9) Confidence 0.60 Published 1990 Journal Circulation Section Abstract Doc Link 2163778 Disease Relevance 0.18 Pain Relevance 0.40
Elastase expression, elastase activity and cell survival after sulphasalazine exposure to HL-60 and U937
Gene_expression (expression) of Elastase in HL-60
10) Confidence 0.60 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.06 Pain Relevance 0
Elastase expression, elastase activity and cell survival after sulphasalazine exposure to HL-60 and U937
Gene_expression (expression) of elastase in HL-60
11) Confidence 0.60 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.06 Pain Relevance 0
Can mutations in ELA2, neutrophil elastase expression or differential cell toxicity explain sulphasalazine-induced agranulocytosis?


Gene_expression (expression) of ELA2 in neutrophil associated with agranulocytosis and toxicity
12) Confidence 0.60 Published 2004 Journal BMC Blood Disord Section Title Doc Link PMC535939 Disease Relevance 0.82 Pain Relevance 0.05
Neutrophil elastase expression and ELA2 mutations do, however, not seem to be involved in the etilogy of sulphasalazine-induced agranulocytosis.
Gene_expression (expression) of ELA2 in Neutrophil associated with agranulocytosis
13) Confidence 0.60 Published 2004 Journal BMC Blood Disord Section Abstract Doc Link PMC535939 Disease Relevance 0.85 Pain Relevance 0
causes accumulation of canine neutrophil elastase in the cytosolic compartments [12], and mutations in ELA2 may disrupt the AP3?
Gene_expression (mutations) of elastase in neutrophil
14) Confidence 0.58 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.56 Pain Relevance 0
Furthermore, mutations in the proto-oncogene GFI1, a transcriptional repressor of ELA2, causes over-expression of neutrophil elastase in mice, thus, making them neutropenic [14].
Gene_expression (expression) of elastase in neutrophil
15) Confidence 0.58 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.58 Pain Relevance 0
Plasma levels of peptide B beta, a product of fibrin degradation by human neutrophil elastase, were approximately 15-fold higher (p less than 0.001) in patients with unstable angina or AMI (588 +/- 171 pmol/l, mean +/- SEM) compared with those in patients with stable angina (37 +/- 25 pmol/l) or control subjects (40 +/- 22 pmol/l), confirming intense in vivo neutrophil activation.
Gene_expression (product) of elastase in neutrophil associated with angina and myocardial infarction
16) Confidence 0.58 Published 1989 Journal Circulation Section Abstract Doc Link 2537159 Disease Relevance 1.51 Pain Relevance 0.75
Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock.
Gene_expression (levels) of elastase associated with stress and sepsis
17) Confidence 0.56 Published 2005 Journal Clin. Chem. Lab. Med. Section Title Doc Link 15843228 Disease Relevance 1.05 Pain Relevance 0.13
NE spillover into the forearm circulation was estimated as the product of delta VA-NE and FAF after three clonidine infusions.
Gene_expression (product) of delta VA-NE in forearm associated with clonidine
18) Confidence 0.56 Published 1985 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2414577 Disease Relevance 0.09 Pain Relevance 0.45
Protein expression of human neutrophil elastase in lymphoma U937 cells was not affected by treatment with concentrations equivalent to therapeutic doses.
Gene_expression (expression) of elastase in neutrophil associated with lymphatic system cancer
19) Confidence 0.52 Published 2004 Journal BMC Blood Disord Section Abstract Doc Link PMC535939 Disease Relevance 1.07 Pain Relevance 0.03
We also performed in vitro studies of the blood cell lines HL60 and U937 after sulphasalazine exposure with respect to cell survival index, neutrophil elastase protein expression and activity.


Gene_expression (expression) of elastase in neutrophil
20) Confidence 0.52 Published 2004 Journal BMC Blood Disord Section Abstract Doc Link PMC535939 Disease Relevance 1.05 Pain Relevance 0.03

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