INT85808

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Context Info
Confidence 0.77
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 1.94
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BMP2) growth (BMP2) extracellular region (BMP2)
embryo development (BMP2) protein complex (BMP2) cell-cell signaling (BMP2)
Anatomy Link Frequency
chondrocytes 3
cartilage 3
BMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 42 93.84 High High
backache 1 86.88 High High
Pain 23 75.60 Quite High
Osteoarthritis 57 65.28 Quite High
Inflammation 24 46.96 Quite Low
fibrosis 2 15.00 Low Low
rheumatoid arthritis 14 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Closed Fractures 2 91.92 High High
Bone Fracture 2 91.52 High High
Aging 18 87.12 High High
Low Back Pain 5 86.88 High High
Apoptosis 30 86.64 High High
Temporomandibular Joint Syndrome 1 85.12 High High
Fracture Healing 32 80.64 Quite High
Heterotopic Ossification 30 78.24 Quite High
Osteoporosis 23 77.80 Quite High
Pain 23 75.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We speculate that the cartilage in the near surrounding of the defect and the synovia may play an important role controlling BMP-2 release and that the assembly of the different receptors influences BMP-driven effects [44].
Localization (release) of BMP-2 in cartilage
1) Confidence 0.77 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.08 Pain Relevance 0.10
In addition, a new carrier is under clinical evaluation that will offer longer rhBMP-2 sustained release and compression resistance, further expanding the clinical utility of rhBMP-2.
Localization (release) of rhBMP-2
2) Confidence 0.75 Published 2009 Journal Conf Proc IEEE Eng Med Biol Soc Section Abstract Doc Link 19963455 Disease Relevance 0.18 Pain Relevance 0.09
After publication of the results gained for the regulators of cartilage metabolism bFGF and IGF-I [3], this article focuses on the role of the Bone morphogenetic proteins 2 and 7 (BMP-2, BMP-7) that both are recognized as candidate growth factors with good potential in cartilage tissue engineering as well as cartilage repair.
Localization (role) of BMP-2 in cartilage
3) Confidence 0.72 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.23 Pain Relevance 0.16
After publication of the results gained for the regulators of cartilage metabolism bFGF and IGF-I [3], this article focuses on the role of the Bone morphogenetic proteins 2 and 7 (BMP-2, BMP-7) that both are recognized as candidate growth factors with good potential in cartilage tissue engineering as well as cartilage repair.
Localization (role) of Bone morphogenetic proteins 2 and 7 in cartilage
4) Confidence 0.72 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.23 Pain Relevance 0.16
RESULTS: BMP-2 was predominantly localized in chondrocytes around the damaged areas of the articular disks.
Localization (localized) of BMP-2 in chondrocytes
5) Confidence 0.62 Published 1999 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 10625847 Disease Relevance 0.09 Pain Relevance 0
are present in ossifying matrix and chondrocytes are present adjacent to cartilaginous areas of OPLL tissues, and that BMP-2 is also localized in mesenchymal cells with fibroblastic features in the immediate vicinity of the cartilaginous areas, and that nonossified ligaments do not contain either of these growth factors.
Localization (localized) of BMP-2 in chondrocytes
6) Confidence 0.59 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.35 Pain Relevance 0
are present at ossifying matrix and chondrocytes of ossifying ligaments, and that only BMP-2 is localized at mesenchymal cells adjacent to these areas, and that nonossified ligament does not contain these growth factors.
Localization (localized) of BMP-2 in chondrocytes
7) Confidence 0.59 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.13 Pain Relevance 0
The results of this group were compared with a group treated with rhBMP-2 and 3 control groups including defects treated with demineralized bone matrix, ?
Localization (treated) of rhBMP-2
8) Confidence 0.56 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.32 Pain Relevance 0
For example, polylactic acid scaffolds have been engineered to release recombinant BMP-2 in a sustained fashion, which was sufficient to induce a favorable chondrogenic response in vitro [146].
Localization (release) of BMP-2
9) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 0.34 Pain Relevance 0

General Comments

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