INT85809

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 46
Total Number 49
Disease Relevance 9.91
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BMP2) growth (BMP2) extracellular region (BMP2)
embryo development (BMP2) protein complex (BMP2) cell-cell signaling (BMP2)
Anatomy Link Frequency
cartilage 4
temporomandibular joint 2
posterior 2
femurs 2
ligaments 2
BMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 84 100.00 Very High Very High Very High
agonist 24 99.96 Very High Very High Very High
Osteoarthritis 153 99.36 Very High Very High Very High
Snapping jaw 4 98.56 Very High Very High Very High
antagonist 30 98.36 Very High Very High Very High
spinal inflammation 20 96.32 Very High Very High Very High
Lasting pain 1 90.96 High High
Inflammation 46 88.28 High High
cytokine 148 86.32 High High
metalloproteinase 19 74.96 Quite High
Disease Link Frequency Relevance Heat
Congenital Anomalies 11 99.56 Very High Very High Very High
Pulmonary Hypertension 85 99.42 Very High Very High Very High
Osteoarthritis 167 99.36 Very High Very High Very High
Focal Cartilage Defect 33 99.04 Very High Very High Very High
Temporomandibular Joint Syndrome 4 98.56 Very High Very High Very High
Metabolic Disorder 27 97.24 Very High Very High Very High
Tibial Fractures 58 97.12 Very High Very High Very High
Osteoporosis 149 96.48 Very High Very High Very High
Low Back Pain 21 96.32 Very High Very High Very High
Osteophyte 10 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: The purpose of this study was to analyze the expression of bone morphogenetic protein-2 (BMP-2) in patients with internal derangement of the temporomandibular joint.
Spec (analyze) Gene_expression (expression) of BMP-2 in temporomandibular joint associated with snapping jaw
1) Confidence 0.78 Published 1999 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 10625847 Disease Relevance 0.10 Pain Relevance 0.10
BMP-2 expression was also found in synovial cells and endothelial cells of blood vessels.
Gene_expression (expression) of BMP-2 in endothelial cells
2) Confidence 0.78 Published 1999 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 10625847 Disease Relevance 0.08 Pain Relevance 0
OBJECTIVE: The purpose of this study was to analyze the expression of bone morphogenetic protein-2 (BMP-2) in patients with internal derangement of the temporomandibular joint.
Spec (analyze) Gene_expression (expression) of bone morphogenetic protein-2 in temporomandibular joint associated with snapping jaw
3) Confidence 0.78 Published 1999 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 10625847 Disease Relevance 0.10 Pain Relevance 0.10
BMP-2 expression is not only found in mesenchymal condensation in embryonic development [6], but is also able to induce chondrogenesis in human mesenchymal stem cells in culture [7].
Gene_expression (expression) of BMP-2 in mesenchymal condensation
4) Confidence 0.74 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.06 Pain Relevance 0.04
This was confirmed by a study that demonstrated a decisive role for BMPs in osteophyte formation and synovial thickening during OA [30], although the presented data do not allow concluding that BMP-2 plays an important role in the onset of OA, because healthy patients also expressed intraarticular BMP-2.
Gene_expression (expressed) of BMP-2 in thickening associated with osteophyte and osteoarthritis
5) Confidence 0.65 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.59 Pain Relevance 0.24
In order to measure concentrations of the indicated proteins, commercially available ELISA kits provided by R&D Systems (Wiesbaden-Nordenstadt, Germany) for BMP-2, BMP-7, bFGF, IGF-I, IL-1?
Gene_expression (provided) of BMP-2
6) Confidence 0.64 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.16 Pain Relevance 0
There was a statistically significant medium correlation between initial BMP-2 levels and the IKDC Score differences with a Pearson coefficient of 0.554 (p = 0.0003, figure 3), and a significant low correlation of BMP-2 concentrations with the Lysholm Score differences with a Pearson coefficient of 0.378 (p = 0.019).
Gene_expression (levels) of BMP-2
7) Confidence 0.64 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.06 Pain Relevance 0.08
BMP-2 and BMP-7 belong to the transforming growth factor-beta (TGF-?)
Gene_expression (belong) of BMP-2
8) Confidence 0.64 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.11 Pain Relevance 0.10
ELISAs for BMP-2, BMP-7, bFGF, IGF-1, IL-1?
Gene_expression (ELISAs) of BMP-2
9) Confidence 0.64 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.17 Pain Relevance 0
In fact, while frontal skin showed significant overexpression of BDNF, BMP2, L1-CAM, Meteorin and NR-CAM and significant underexpression of Midkine respect to the velvet, significant gene expression differences between pedicle skin and velvet were restricted to FGF2 and NR-CAM.
Gene_expression (overexpression) of BMP2 in skin associated with bdmf
10) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0.14
Finally, BMP2 expression in the antler was also established by Feng and colleagues [20] although they did not provide details on its tissue or cellular distribution.
Gene_expression (expression) of BMP2
11) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0.12 Pain Relevance 0.06
BMP-2, which can be produced with recombinant technology, is highly osteoinductive, inducing bone formation by stimulating the differentiation of mesenchymal cells into chrondroblasts and osteoblasts.
Gene_expression (produced) of BMP-2 in osteoblasts
12) Confidence 0.60 Published 2005 Journal Acta Orthop Belg Section Abstract Doc Link 16152845 Disease Relevance 0.24 Pain Relevance 0.09
Our data demonstrate significant levels of BMP-2 in the synovial fluid of all knees without dependency of the presence or the size of a cartilage lesion.
Gene_expression (levels) of BMP-2 in cartilage
13) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.13 Pain Relevance 0.09
Therefore, data about intraarticular levels of BMP-2 and BMP-7 in knees with circumscribed cartilage lesions and their correlation with clinical scores are introduced.
Gene_expression (levels) of BMP-2 in cartilage
14) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.07 Pain Relevance 0.11
Association between expression of the Bone morphogenetic proteins 2 and 7 in the repair of circumscribed cartilage lesions with clinical outcome

Background

Gene_expression (expression) of Bone morphogenetic proteins 2 and 7 in cartilage
15) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Title Doc Link PMC2920860 Disease Relevance 0 Pain Relevance 0
BMP-2 expression did not correlate with cartilage defect size; average expression in both intervention groups (ACI and microfracturing) did not statistically significant differ (121.90 ± 83.44 pg/ml vs. 119.03 ± 34.30 pg/ml, p = 0.14).
Gene_expression (expression) of BMP-2 in cartilage associated with focal cartilage defect
16) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.38 Pain Relevance 0.23
The overexpression of BMP-2 protein in the posterior longitudinal ligament matrix can augment the signaling activity of endogenously produced BMPs.
Gene_expression (overexpression) of BMP-2 protein in posterior
17) Confidence 0.57 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.06 Pain Relevance 0.20
The histopathologic features of OPLL are characterized by the abnormal expression of BMP-2, TGF-?
Gene_expression (expression) of BMP-2
18) Confidence 0.57 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.32 Pain Relevance 0
Further the posterior longitudinal ligament matrix has an imbalance between the expression of BMP-2 agonists and the potential existence of antagonists.
Gene_expression (expression) of BMP-2 in ligament associated with antagonist and agonist
19) Confidence 0.57 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.06 Pain Relevance 0.22
The most likely explanation for this is two SNPs variations may yield the alternative transcript and translation with abnormal function and further cause the overexpression of BMP-2 protein in the posterior longitudinal ligament matrix.
Gene_expression (overexpression) of BMP-2 protein in posterior
20) Confidence 0.57 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.09 Pain Relevance 0.09

General Comments

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