INT85827

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 4.58
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
diaphragm 2
IMR-32 1
bone marrow 1
hippocampus 1
vs (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 25 100.00 Very High Very High Very High
imagery 14 99.52 Very High Very High Very High
Hippocampus 23 98.72 Very High Very High Very High
antagonist 15 93.76 High High
Inflammatory response 46 90.08 High High
addiction 94 89.80 High High
cytokine 38 86.64 High High
lidocaine 6 85.60 High High
metalloproteinase 1 82.68 Quite High
alcohol 8 79.28 Quite High
Disease Link Frequency Relevance Heat
Cancer 205 99.92 Very High Very High Very High
Disease 75 98.64 Very High Very High Very High
Neuroblastoma 141 97.52 Very High Very High Very High
Body Weight 16 93.20 High High
Drug Dependence 18 89.80 High High
INFLAMMATION 132 89.72 High High
Parkinson's Disease 5 86.40 High High
Death 25 83.96 Quite High
Skin Cancer 159 80.80 Quite High
Cognitive Disorder 41 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interactions were assessed using a Fixed Interval (FI) schedule of reinforcement shown previously in our laboratory to be modulated by VS DA function.
Regulation (modulated) of VS DA associated with dopamine
1) Confidence 0.36 Published 2000 Journal Behav. Brain Res. Section Abstract Doc Link 10628729 Disease Relevance 0 Pain Relevance 0.67
In contrast, AI, although not normally modulating FI performance, can apparently influence VS DA function, possibly when alterations in activity are invoked in AI.
Regulation (influence) of VS DA associated with dopamine
2) Confidence 0.21 Published 2000 Journal Behav. Brain Res. Section Abstract Doc Link 10628729 Disease Relevance 0 Pain Relevance 0.47
Even in the neuroblastoma animal model, D6 induced a statistically significant more pronounced tumor growth reduction than D1 evaluated by means of BLI (Figure 6, panel C: D6 vs both D1 and control, P < 0.001).
Regulation (control) of vs associated with neuroblastoma, cancer and imagery
3) Confidence 0.19 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.90 Pain Relevance 0.05
mRNA expression and a 15-fold increase in IL-6 in the hippocampus at six hours after LPS injection (Figures 1e and 1f; P < 0.001 vs control).
Regulation (control) of vs in hippocampus associated with hippocampus
4) Confidence 0.18 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.33 Pain Relevance 0.30
8) for case vs control differences in single samples of individually genotyped individuals.
Regulation (control) of vs
5) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809089 Disease Relevance 0.32 Pain Relevance 0.26
The SNPs that we identify in this secondary analysis thus a) display t values with p<0.05 significance in one abuser vs control comparison, b) cluster, so that at least four of these positive SNPs lie within 10kb of each other in this abuser vs control comparison, c) identify the same genes as clustered positive SNPs from the other sample (Table 2, legend, and Table S1).
Regulation (control) of vs
6) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809089 Disease Relevance 0 Pain Relevance 0
The percentage of both IMR-32 and LB24 cells with polarized mitochondria decreased after 18 hours treatment with the above mentioned doses of D1 and D6: this reduction was statistically significant and highlighted, also in this context, the major sensitivity of neuroblastoma cells to D6 (Figure 5, panel C: IMR-32: D1 vs control: *, P < 0.05 and D6 vs control: ***, P < 0.001; LB24: both D1 and D6 vs control: *, P < 0.05).
Regulation (control) of vs in IMR-32 associated with neuroblastoma
7) Confidence 0.12 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.72 Pain Relevance 0
More importantly, the survival rate was significantly increased only by the D6 treatment (Figure 6, panel D: D6 vs control, P = 0.0007; D6 vs D1, P = 0.0169).
Regulation (control) of vs
8) Confidence 0.12 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.90 Pain Relevance 0.05
In future studies it will be important to compare radiation effects on endothelial cells vs. tumor-infiltrating bone marrow-derived cells in deficient angiogenesis and vasculogenic rescue.
Regulation (effects) of vs in bone marrow associated with cancer
9) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.67 Pain Relevance 0.04
For the healthy (left) hemisphere, all 8 animals presented similar values for both, BOLD signal intensity (mean±SD across all fMRI sessions; 3.43±0.15% for the control group vs 3.56±0.07% for the treated group) and activated volumes (mean±SD across all fMRI sessions; 8.35±1.55 mm3 for the control group vs 9.57±1.42 mm3 for the treated group).
Regulation (values) of vs
10) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943902 Disease Relevance 0 Pain Relevance 0
Upon further testing by pairwise comparisons, there were changes between baseline vs 5 minutes (p?
Regulation (changes) of vs
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.05 Pain Relevance 0.03
Statistical testing using the Wilcoxon test displayed changes between baseline vs 5 minutes (p?
Regulation (changes) of vs
12) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.12 Pain Relevance 0.06
Upon further testing by pairwise comparisons, there were changes between baseline vs 5 minutes (p?
Regulation (changes) of vs
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0 Pain Relevance 0
Long-term studies are needed to establish a clinical value of the S-VS.


Regulation (value) of S-VS
14) Confidence 0.03 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1471796 Disease Relevance 0.57 Pain Relevance 0.05
Furthermore, the differences in MHC expression between two groups (normal, dMHC (-) vs affected, dMHC (-); affected, dMHC (-) vs affected, dMHC (+)), between muscles (TC muscle vs diaphragm), or among ages (1, 2, 4, 6 months, and 1 year) were evaluated by Yates's chi-square test.


Regulation (affected) of vs in diaphragm
15) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2257929 Disease Relevance 0 Pain Relevance 0
Furthermore, the differences in MHC expression between two groups (normal, dMHC (-) vs affected, dMHC (-); affected, dMHC (-) vs affected, dMHC (+)), between muscles (TC muscle vs diaphragm), or among ages (1, 2, 4, 6 months, and 1 year) were evaluated by Yates's chi-square test.


Regulation (affected) of vs in diaphragm
16) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2257929 Disease Relevance 0 Pain Relevance 0
These findings suggested that the use of physically distinct NCoA binding interfaces may be important in controlling specific genes by conformationally restricted ligands and may affect the overall activity of synthetic retinoids vs natural molecules.
Spec (may) Regulation (affect) of vs
17) Confidence 0.02 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC113761 Disease Relevance 0 Pain Relevance 0

General Comments

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