INT85829

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Context Info
Confidence 0.68
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 12.59
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (CA9) nucleolus (CA9) plasma membrane (CA9)
nucleus (CA9)
Anatomy Link Frequency
renal tubules 1
red blood cells 1
bile 1
CA9 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 1 97.92 Very High Very High Very High
abdominal pain 3 97.24 Very High Very High Very High
Chronic pancreatitis 5 97.16 Very High Very High Very High
Bile 8 96.48 Very High Very High Very High
pain flank 5 93.64 High High
cINOD 1 91.68 High High
imagery 8 86.72 High High
Angina 1 84.48 Quite High
tolerance 2 82.68 Quite High
palliative 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 9 99.96 Very High Very High Very High
Renal Cancer 316 99.84 Very High Very High Very High
Malaria 54 99.84 Very High Very High Very High
Pancreatic Cancer 7 99.80 Very High Very High Very High
Cancer 285 99.72 Very High Very High Very High
Appetite Loss 1 99.68 Very High Very High Very High
Stomach Cancer 4 99.48 Very High Very High Very High
Impaired Glucose Tolerance 1 99.16 Very High Very High Very High
Weight Loss 3 98.96 Very High Very High Very High
Cholangiocarcinoma 3 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High levels of CAIX expression are associated with a more favorable prognosis and a greater likelihood of a response to IL-2 [32,33].
Gene_expression (expression) of CAIX
1) Confidence 0.68 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667482 Disease Relevance 0.69 Pain Relevance 0
Carbonic anhydrase IX (CAIX) expression is HIF dependent and its expression is increased in VHL mutated RCC.
Gene_expression (expression) of Carbonic anhydrase IX associated with renal cancer
2) Confidence 0.68 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667482 Disease Relevance 0.82 Pain Relevance 0
Carbonic anhydrase IX (CAIX) expression is HIF dependent and its expression is increased in VHL mutated RCC.
Gene_expression (expression) of CAIX associated with renal cancer
3) Confidence 0.68 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667482 Disease Relevance 0.71 Pain Relevance 0
Serum CA19-9 levels and exacerbation of glucose intolerance were retrospectively noted to have been elevated in 1 patient.
Gene_expression (levels) of CA19-9 associated with impaired glucose tolerance
4) Confidence 0.52 Published 1999 Journal Intern. Med. Section Abstract Doc Link 10628933 Disease Relevance 1.26 Pain Relevance 0.48
Our data showed a conspicuous overexpression of CEACAM6 and MUC1 (CA19-9) in pancreatic cancer and cholangiocarcinoma samples, according to the hypothesis that bile fluid collects cancer-associated protein leaking from the tumor microenvironment.
Gene_expression (overexpression) of CA19-9 in bile associated with bile, cholangiocarcinoma, cancer and pancreatic cancer
5) Confidence 0.24 Published 2009 Journal J. Proteome Res. Section Abstract Doc Link 19055478 Disease Relevance 1.85 Pain Relevance 0.43
Although a large study correlating HIF-1alpha expression with prognosis is lacking in gastric cancer, the immunohistochemical expression of HIF-1alpha target genes (Glut-1, VEGF, CA9, iNOS) is associated with a poor prognosis.
Gene_expression (expression) of CA9 associated with stomach cancer
6) Confidence 0.22 Published 2005 Journal Eur. J. Cancer Section Abstract Doc Link 16290133 Disease Relevance 1.33 Pain Relevance 0.09
Tumor markers were drawn for CA-19-9, CA-125, beta-HCG, and alpha-fetoprotein.
Gene_expression (drawn) of CA-19-9 associated with cancer
7) Confidence 0.10 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2409333 Disease Relevance 0.49 Pain Relevance 0
CA19-9 was also positive both in the tumor cells and normal epithelium of the renal tubules.
Gene_expression (positive) of CA19-9 in renal tubules associated with cancer
8) Confidence 0.09 Published 2003 Journal Hinyokika Kiyo Section Abstract Doc Link 12696186 Disease Relevance 0.88 Pain Relevance 0.08
Both serum levels of CEA and CA19-9 were elevated to 36.9 ng/ml and 119 u/ml, respectively.
Gene_expression (levels) of CA19-9
9) Confidence 0.09 Published 2003 Journal Hinyokika Kiyo Section Abstract Doc Link 12696186 Disease Relevance 0.84 Pain Relevance 0.09
Prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP) are well known as specific tumor markers of prostate cancer, but carcinoembryonic antigen (CEA)- and carbohydrate antigen 19-9 (CA19-9)-producing adenocarcinoma originating in the prostate is rare.
Gene_expression (producing) of CA19-9 associated with adenocarcinoma, cancer and prostate cancer
10) Confidence 0.07 Published 1999 Journal Urol. Int. Section Abstract Doc Link 10738193 Disease Relevance 0.97 Pain Relevance 0.08
Plasmodium falciparum Apical Membrane Antigen 1 (PfAMA1) is a candidate vaccine antigen expressed by merozoites and sporozoites.
Gene_expression (expressed) of Membrane Antigen 1 associated with malaria
11) Confidence 0.05 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2602972 Disease Relevance 0.33 Pain Relevance 0
G250

G250 is a chimeric monoclonal antibody directed against carbonic anhydrase IX, a heat-sensitive surface antigen which is ubiquitously expressed in RCC [56].

Gene_expression (expressed) of anhydrase IX associated with renal cancer
12) Confidence 0.03 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2527326 Disease Relevance 0.51 Pain Relevance 0
Serum tumour marker tests revealed abnormally high levels of CA-125 (182 IU/ml), but normal levels of CA-19-9 (20,68 IU/ml), CA 15-3 (16 IU/ml) and CEA (1.1 ng/ml).
Gene_expression (levels) of CA-19-9 associated with cancer
13) Confidence 0.02 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1863429 Disease Relevance 0.90 Pain Relevance 0.14
Two leading vaccine candidates are apical membrane antigen 1 (AMA1) and merozoite surface protein 1 (MSP1), both of which are expressed on the merozoite surface and are thought to be involved in invasion of red blood cells.
Gene_expression (expressed) of membrane antigen 1 in red blood cells
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809736 Disease Relevance 0.96 Pain Relevance 0

General Comments

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