INT85834

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 7
Disease Relevance 2.53
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Blvra) cytoplasm (Blvra)
Anatomy Link Frequency
neuronal 2
brain 2
neurons 1
Blvra (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 21 98.68 Very High Very High Very High
halothane 7 95.36 Very High Very High Very High
anesthesia 7 94.56 High High
Substantia nigra 7 53.60 Quite High
Disease Link Frequency Relevance Heat
Brain Hemorrhage 14 99.32 Very High Very High Very High
Injury 14 98.24 Very High Very High Very High
Cv Unclassified Under Development 14 98.10 Very High Very High Very High
Middle Cerebral Artery Infarction 35 98.04 Very High Very High Very High
Drug Induced Neurotoxicity 7 98.00 Very High Very High Very High
Stress 7 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data suggest that pharmacological modulation of BVR expression is a possible new direction for protecting neurons against ischemic injury and oxidative stress.
Gene_expression (expression) of BVR in neurons associated with stress and injury
1) Confidence 0.78 Published 1999 Journal Brain Res. Section Abstract Doc Link 10629743 Disease Relevance 0.45 Pain Relevance 0.08
Should, in the case of ischemia, the conditions favor the antioxidant activity of bilirubin, then we suggest that increase in BVR expression in ischemic penumbra may present a cellular defense mechanism against free radical-mediated neuronal damage.
Gene_expression (expression) of BVR in neuronal associated with ischemia
2) Confidence 0.68 Published 1999 Journal Brain Res. Section Abstract Doc Link 10629743 Disease Relevance 0.36 Pain Relevance 0.12
Enhanced neuronal expression of the oxidoreductase--biliverdin reductase--after permanent focal cerebral ischemia.
Gene_expression (expression) of biliverdin reductase in neuronal associated with brain hemorrhage and ischemia
3) Confidence 0.68 Published 1999 Journal Brain Res. Section Title Doc Link 10629743 Disease Relevance 0.50 Pain Relevance 0.14
This is the first report on increased neuronal levels of biliverdin reductase (BVR) in response to ischemic brain injury.
Gene_expression (levels) of biliverdin reductase in brain associated with brain hemorrhage
4) Confidence 0.60 Published 1999 Journal Brain Res. Section Abstract Doc Link 10629743 Disease Relevance 0.17 Pain Relevance 0.04
This is the first report on increased neuronal levels of biliverdin reductase (BVR) in response to ischemic brain injury.
Gene_expression (levels) of BVR in brain associated with brain hemorrhage
5) Confidence 0.60 Published 1999 Journal Brain Res. Section Abstract Doc Link 10629743 Disease Relevance 0.17 Pain Relevance 0.04
Furthermore, we interpret the apparent tightly regulated expression of BVR in the ischemic hemisphere as an important factor in protection against bilirubin neurotoxicity.
Gene_expression (expression) of BVR associated with drug induced neurotoxicity
6) Confidence 0.53 Published 1999 Journal Brain Res. Section Abstract Doc Link 10629743 Disease Relevance 0.26 Pain Relevance 0.08
It also examined correlation of the change in BVR expression with display of indices of ischemic tissue injury.
Gene_expression (expression) of BVR associated with injury
7) Confidence 0.53 Published 1999 Journal Brain Res. Section Abstract Doc Link 10629743 Disease Relevance 0.60 Pain Relevance 0.21

General Comments

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