INT85836

Context Info Confidence 0.03 First Reported 1999 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.81 Pain Relevance 1.43

extracellular region (Postn) cell adhesion (Postn) proteinaceous extracellular matrix (Postn) extracellular matrix organization (Postn)

Anatomy Link Frequency skin 1 Postn (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 88 99.98 Morphine 75 99.84 Opioid 52 96.84 Hyperalgesia 22 96.52 ischemia 3 83.20 Inflammatory response 1 76.92 opioid receptor 2 69.00 Neuropeptide 2 63.44 Substantia nigra 1 63.44 allodynia 11 50.24

Disease Link Frequency Relevance Heat Infection 51 100.00 Chlamydia Infection 38 97.36 Hyperalgesia 22 96.52 Cv Unclassified Under Development 2 83.20 INFLAMMATION 6 76.52 Wound Healing 1 75.80 Brain Hemorrhage 2 75.00 Middle Cerebral Artery Infarction 5 68.28 Injury 16 66.96 Immunization 9 55.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For all three of these cytokines peri-incisional skin levels were augmented in morphine treated mice after incision to levels above those observed in the opioid naïve animals.

Positive_regulation (augmented) of peri-incisional in skin associated with opioid, morphine and cytokine

1) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2279109 Disease Relevance 0.42 Pain Relevance 1.28

As judged by Northern and Western blots and activity analysis, despite the apparent loss of BVR from the ischemic core, and its increase in the peri-ischemic region, when compared with the contralateral hemisphere, the overall capacity of the ischemic hemisphere to catalyze the reduction of biliverdin was unchanged throughout the experiment.

Positive_regulation (increase) of peri-ischemic

2) Confidence 0.02 Published 1999 Journal Brain Res. Section Abstract Doc Link 10629743 Disease Relevance 0.40 Pain Relevance 0.15

CTH1/CAF01 and MoPn infection induced a different clearance kinetic

Positive_regulation (induced) of MoPn associated with infection

3) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2874006 Disease Relevance 0.98 Pain Relevance 0

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