INT85839

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 1.61
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Blvra) cytoplasm (Blvra)
Anatomy Link Frequency
brain 2
neurons 1
cerebellum 1
Blvra (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 4 91.96 High High
anesthesia 4 89.32 High High
halothane 4 88.88 High High
ischemia 12 87.28 High High
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 20 99.96 Very High Very High Very High
Brain Hemorrhage 8 99.32 Very High Very High Very High
Injury 8 88.20 High High
Cv Unclassified Under Development 8 87.28 High High
Drug Induced Neurotoxicity 4 25.00 Low Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is the first report on increased neuronal levels of biliverdin reductase (BVR) in response to ischemic brain injury.
Positive_regulation (increased) of BVR in brain associated with brain hemorrhage
1) Confidence 0.70 Published 1999 Journal Brain Res. Section Abstract Doc Link 10629743 Disease Relevance 0.17 Pain Relevance 0.04
This is the first report on increased neuronal levels of biliverdin reductase (BVR) in response to ischemic brain injury.
Positive_regulation (increased) of biliverdin reductase in brain associated with brain hemorrhage
2) Confidence 0.70 Published 1999 Journal Brain Res. Section Abstract Doc Link 10629743 Disease Relevance 0.17 Pain Relevance 0.04
In situ hybridization analysis demonstrated a time dependent increase in BVR mRNA labeling in neurons of the peri-ischemic area.
Positive_regulation (increase) of BVR mRNA in neurons
3) Confidence 0.61 Published 1999 Journal Brain Res. Section Abstract Doc Link 10629743 Disease Relevance 0.54 Pain Relevance 0.21
Six hours after MCAo, increased immunoreactivity for BVR was noted in neurons in the peri-ischemic areas, intraischemic cortical layers 3 and 5, as well as in neurons in regions distant from the borders of vascular distribution of the MCA, such as those in substantia nigra, in the Purkinje layer of the cerebellum and in the central nucleus of inferior colliculus.
Positive_regulation (increased) of BVR in cerebellum associated with middle cerebral artery infarction and substantia nigra
4) Confidence 0.50 Published 1999 Journal Brain Res. Section Abstract Doc Link 10629743 Disease Relevance 0.72 Pain Relevance 0.25

General Comments

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