INT85843

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Context Info
Confidence 0.35
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.13
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BPI) extracellular region (BPI) cytoplasm (BPI)
Anatomy Link Frequency
hepatocytes 1
nodes 1
MPTP 1
BPI (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain score 17 99.68 Very High Very High Very High
Paracetamol 9 99.42 Very High Very High Very High
Cancer pain 67 98.90 Very High Very High Very High
Leflunomide 8 98.64 Very High Very High Very High
Duloxetine 84 98.32 Very High Very High Very High
anesthesia 1 93.64 High High
Pain 140 91.92 High High
Fibrositis 147 86.24 High High
depression 20 69.56 Quite High
Breakthrough pain 5 50.00 Quite Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 5 100.00 Very High Very High Very High
Injury 8 99.82 Very High Very High Very High
Pain 170 99.64 Very High Very High Very High
Brain Injury 6 99.16 Very High Very High Very High
Cancer Pain 67 98.90 Very High Very High Very High
Disease 3 97.96 Very High Very High Very High
Complex Regional Pain Syndromes 1 90.48 High High
Stress 6 89.68 High High
Syndrome 3 89.56 High High
Necrosis 1 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BTCP was associated with higher pain scores and functional interference on the BPI.
Negative_regulation (interference) of BPI associated with pain score and cancer pain
1) Confidence 0.35 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004585 Disease Relevance 2.18 Pain Relevance 1.83
Redundant nodes containing entities annotated in such inconsistent styles cannot be properly removed in BPI.
Negative_regulation (removed) of BPI in nodes
2) Confidence 0.33 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0 Pain Relevance 0
Patients were allowed to increase their dose to 120 mg/day any time between weeks 13 and 23 if they exhibited <50% reduction in their BPI average pain score.
Negative_regulation (reduction) of BPI associated with pain score
3) Confidence 0.11 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 1.21 Pain Relevance 1.08
Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes.
Negative_regulation (inhibition) of mitochondrial permeability transition in hepatocytes associated with paracetamol, injury and leflunomide
4) Confidence 0.03 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 16979204 Disease Relevance 0.67 Pain Relevance 0.77
The opening of the mitochondrial permeability transition pore (MPTP) is inhibited by CsA, thereby maintaining the mitochondrial membrane potential and calcium homeostasis in isolated mitochondrial.
Negative_regulation (inhibited) of mitochondrial permeability transition pore in MPTP associated with parkinson's disease
5) Confidence 0.00 Published 1999 Journal Exp. Neurol. Section Abstract Doc Link 10630207 Disease Relevance 1.07 Pain Relevance 0.09

General Comments

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