INT85844

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 11.08
Pain Relevance 10.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
glial cell 2
DRG 2
sensory neuron 1
ventricles 1
CSF 1
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 4 100.00 Very High Very High Very High
electroacupuncture 2 100.00 Very High Very High Very High
Somatostatin 16 99.96 Very High Very High Very High
antidepressant 20 99.92 Very High Very High Very High
Nerve growth factor 142 99.84 Very High Very High Very High
Endep 14 99.82 Very High Very High Very High
fluoxetine 4 99.52 Very High Very High Very High
Inflammation 20 99.36 Very High Very High Very High
Pain 34 99.32 Very High Very High Very High
Desipramine 2 99.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 37 99.36 Very High Very High Very High
Pain 32 99.32 Very High Very High Very High
Headache 26 98.80 Very High Very High Very High
Convulsion 22 98.80 Very High Very High Very High
Nociception 10 98.36 Very High Very High Very High
Inflammatory Pain 3 97.52 Very High Very High Very High
Ganglion Cysts 114 97.12 Very High Very High Very High
Spinal Injuries 9 96.60 Very High Very High Very High
Fibromyalgia 6 96.28 Very High Very High Very High
Hyperalgesia 16 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic (14 days) administration of different classes of antidepressant drugs, including tranylcypromine, desipramine, or fluoxetine, did not significantly affect the GDNF, GFRalpha-1, GFRalpha-2, or RET mRNA levels in CA1, CA3, and dentate gyrus areas of hippocampus.
Neg (not) Regulation (affect) of GDNF in hippocampus associated with desipramine, antidepressant, hippocampus and fluoxetine
1) Confidence 0.50 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.82 Pain Relevance 0.30
Differently, a rapid up-regulation of GDNF was observed in the rostral stump.
Regulation (regulation) of GDNF
2) Confidence 0.45 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.69 Pain Relevance 0.14
These results suggested that amitriptyline-induced GDNF synthesis and release occurred at the transcriptional level, and may be regulated by MEK/MAPK signalling.
Regulation (regulated) of GDNF associated with endep
3) Confidence 0.44 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.14 Pain Relevance 0.61
We therefore investigated the effects of intrathecal GDNF or NGF on P2X(3) expression in adult rat spinal cord and dorsal root ganglia (DRG).
Spec (investigated) Regulation (effects) of GDNF in DRG associated with nerve growth factor, spinal cord and intrathecal
4) Confidence 0.44 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11331415 Disease Relevance 0.27 Pain Relevance 0.57
[Effects of electroacupuncture on GDNF positive cell immunoreactivity in local dermal tissue of the inflammatory pain focus in the rat of adjuvant arthritis].
Regulation ([Effects) of GDNF associated with ipn, experimental arthritis, electroacupuncture and arthritis
5) Confidence 0.40 Published 2006 Journal Zhongguo Zhen Jiu Section Title Doc Link 16813188 Disease Relevance 0.19 Pain Relevance 0.38
In the present study, a direct comparison of the in vivo effects of GDNF and NTN was performed using osmotic minipumps delivering either GDNF or NTN over a 30-day period into rat lateral cerebral ventricles.
Regulation (effects) of GDNF in ventricles
6) Confidence 0.38 Published 1999 Journal Exp. Neurol. Section Abstract Doc Link 10630208 Disease Relevance 0 Pain Relevance 0.06
In the present study, we found for the first time that axonal regeneration did not greatly differ between the GDNF and Control groups, but the combination of GDNF and OECs promoted the OEC repair of spinal injuries, suggesting the synergism of GDNF and OECs.
Neg (not) Regulation (differ) of GDNF in spinal associated with spinal injuries
7) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013062 Disease Relevance 0.83 Pain Relevance 0
We observed parallel effects of GDNF and NGF on the Na(v)1.3 sodium channel transcript levels in axotomized DRG.
Regulation (effects) of GDNF in DRG associated with dorsal root ganglion, nerve growth factor and sodium channel
8) Confidence 0.38 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12163518 Disease Relevance 0.48 Pain Relevance 0.71
The results also imply that regulation of the binding components of GDNF receptor complex may mediate the adaptive responses of the GDNF system to acute and chronic stimulation.
Regulation (regulation) of GDNF
9) Confidence 0.37 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.67 Pain Relevance 0.22
Thus, we tested the hypothesis that prolonged GDNF administration would regulate SOM expression in sensory neuron cell bodies in the dorsal root ganglia (DRG) and activity-induced release of SOM from axon terminals in the dorsal horn.
Regulation (regulate) of GDNF in sensory neuron associated with dorsal root ganglion, dorsal horn and somatostatin
10) Confidence 0.32 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11461957 Disease Relevance 0.36 Pain Relevance 0.79
The effect of this antibody coincided with the down-regulation of GDNF immunoreactivity in response to inflammation, suggesting that GDNF supports biochemical changes that contribute to hyperalgesia.
Regulation (immunoreactivity) of GDNF associated with hyperalgesia and inflammation
11) Confidence 0.27 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617957 Disease Relevance 1.10 Pain Relevance 1.04
In conditions of pain relief ALCAR normalized peripheral and central alterations of GDNF and ARTN levels.
Regulation (alterations) of GDNF associated with pain
12) Confidence 0.24 Published 2010 Journal Neuroscience Section Abstract Doc Link 20302919 Disease Relevance 1.07 Pain Relevance 0.97
GDNF immunoreactivity was visualized with brown staining using diaminobenzidine (DAB) and H2O2 as substrate for 5 min, and observed with a light microscope.
Regulation (immunoreactivity) of GDNF
13) Confidence 0.24 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.07 Pain Relevance 0.09
However, the effect of antidepressants on modulation of glial cell line-derived neurotrophic factor (GDNF), which has potent and widespread effects, remains unknown.
Regulation (modulation) of GDNF in glial cell associated with antidepressant
14) Confidence 0.23 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.16 Pain Relevance 0.41
Both brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) levels are altered in pathological pain states, and exogenous BDNF and GDNF have multiple effects on pain behavior, depending on the animal model (i.e. inflammatory vs. neuropathic).
Regulation (altered) of glial cell-derived neurotrophic factor in glial cell associated with pain, inflammation and neuropathic pain
15) Confidence 0.22 Published 2009 Journal Brain Res. Section Abstract Doc Link 19524560 Disease Relevance 0.67 Pain Relevance 0.59
Additionally, sensory neurons that are postnatally dependent on GDNF for survival bind the isolectin B4 (IB4, [2]).
Regulation (dependent) of GDNF in IB4
16) Confidence 0.20 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.61 Pain Relevance 0.90
We found the simultaneous up-regulation of both co-receptor genes for the neurotrophic factor GDNF (Gfra1 and Ret).
Regulation (regulation) of GDNF
17) Confidence 0.14 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.81 Pain Relevance 0.05
A significant positive correlation emerged between CSF values of GDNF and those of somatostatin in CM (r = 0.70, P < 0.02), PCM + PAAH (r = 0.78, P < 0.004), and PFMS patients (r = 0.68, P < 0.008).
Regulation (values) of GDNF in CSF associated with migraine, somatostatin, headache and fibrositis
18) Confidence 0.08 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16556241 Disease Relevance 2.15 Pain Relevance 2.60
Effects of Axonal Transport Facilitator (ATF) (project IV)
Regulation (project) of ATF
19) Confidence 0.06 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837052 Disease Relevance 0 Pain Relevance 0.03

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