INT85855

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.40
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
neuronal 2
leukocyte 2
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 10 99.72 Very High Very High Very High
nMDA receptor 60 98.84 Very High Very High Very High
gABA 56 88.96 High High
Glutamate 78 88.56 High High
Hippocampus 54 85.32 High High
5HT 26 84.44 Quite High
Inflammatory response 1 77.28 Quite High
Neuronal nitric oxide synthase 4 68.72 Quite High
depression 23 61.60 Quite High
Neurotransmitter 6 55.32 Quite High
Disease Link Frequency Relevance Heat
Stress 178 99.42 Very High Very High Very High
Diabetes Mellitus 62 97.96 Very High Very High Very High
Adhesions 11 97.96 Very High Very High Very High
Aging 20 96.24 Very High Very High Very High
Cv Unclassified Under Development 7 95.56 Very High Very High Very High
Post-traumatic Stress Disorder 176 84.96 Quite High
Injury 55 83.52 Quite High
Endotoxemia 17 79.20 Quite High
INFLAMMATION 6 76.92 Quite High
Sepsis 15 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L-NAME significantly reduces the immunoreactivity for NOS.
Negative_regulation (reduces) of NOS Binding (immunoreactivity) of
1) Confidence 0.37 Published 2000 Journal Cornea Section Body Doc Link 10632015 Disease Relevance 0.05 Pain Relevance 0
No significant changes were seen with the SP antibody but immunolabeling for nNOS, H02 (Figure 2) and TH (Figure 1) was decreased (by 40–50%) in the patient with poorly controlled diabetes.



Negative_regulation (decreased) of nNOS Binding (immunolabeling) of associated with diabetes mellitus and substance p
2) Confidence 0.35 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.29 Pain Relevance 0.22
Indeed, NOS bears striking homology to CYP450 (Bredt et al 1991), while KCZ binding to the heme structure within NOS has been found to reduce the maximal velocity of the enzyme (Wolff et al 1993).
Negative_regulation (reduce) of NOS Binding (binding) of
3) Confidence 0.30 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.56 Pain Relevance 0.07
The decrease in NMDA receptor density following TDS stress (Harvey et al 2004) further underlines the involvement of iNOS and not nNOS, since iNOS activation is not regulated by neuronal receptors (McCaslin and Oh 1995).


Negative_regulation (underlines) of nNOS Binding (involvement) of in neuronal associated with stress and nmda receptor
4) Confidence 0.30 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.93 Pain Relevance 0.24
Only one study measured the inducible NOS protein abundance and NOS activity after injection of a cocktail of LPS and IFN-?
Negative_regulation (measured) of NOS Binding (activity) of
5) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1750995 Disease Relevance 0.79 Pain Relevance 0.10
In addition, the protective effect of fasudil on microvascular endothelial cells was significantly blocked by NOS inhibition with L-NAME, without apparent effect on leukocyte adhesion in vitro.
Negative_regulation (blocked) of NOS Neg (inhibition) Binding (inhibition) of in leukocyte associated with adhesions
6) Confidence 0.02 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 0.78 Pain Relevance 0.03

General Comments

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