INT85877

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.87
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
macrophages 1
Il12a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 19 100.00 Very High Very High Very High
Neuritis 7 100.00 Very High Very High Very High
Inflammation 56 99.98 Very High Very High Very High
Angina 6 98.12 Very High Very High Very High
Multiple sclerosis 2 95.32 Very High Very High Very High
Central nervous system 6 93.32 High High
agonist 16 90.76 High High
Demyelination 2 75.00 Quite High
Sciatic nerve 2 68.08 Quite High
Serotonin 32 66.32 Quite High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 7 100.00 Very High Very High Very High
INFLAMMATION 79 99.98 Very High Very High Very High
Immunization 1 99.84 Very High Very High Very High
Myocardial Infarction 5 99.28 Very High Very High Very High
Disease 19 98.90 Very High Very High Very High
Cv General 3 Under Development 6 98.12 Very High Very High Very High
Multiple Sclerosis 6 95.32 Very High Very High Very High
Demyelinating Disease 4 94.20 High High
Infection 4 85.60 High High
Coronary Artery Disease 4 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine whether interleukin (IL)-12 modulates ongoing chronic experimental autoimmune neuritis (EAN), we evaluated the effects of recombinant mouse IL-12 (rmIL-12) in Lewis rats with chronic EAN, induced by immunization with P0 peptide (180-199) plus complete Freund's adjuvant.
Positive_regulation (induced) of rmIL-12 associated with experimental autoimmune neuritis, immunization and neuritis
1) Confidence 0.43 Published 2000 Journal Scand. J. Immunol. Section Abstract Doc Link 10632973 Disease Relevance 0.93 Pain Relevance 0.71
Venlafaxine ameliorated the clinical symptoms of the disease possibly by suppressed production of pro-inflammatory cytokines interleukin-12 (IL-12), p40, TNF-?
Positive_regulation (cytokines) of interleukin-12 associated with inflammation, disease and cytokine
2) Confidence 0.22 Published 2010 Journal J Negat Results Biomed Section Body Doc Link PMC2895576 Disease Relevance 1.28 Pain Relevance 0.35
Venlafaxine ameliorated the clinical symptoms of the disease possibly by suppressed production of pro-inflammatory cytokines interleukin-12 (IL-12), p40, TNF-?
Positive_regulation (cytokines) of IL-12 associated with inflammation, disease and cytokine
3) Confidence 0.22 Published 2010 Journal J Negat Results Biomed Section Body Doc Link PMC2895576 Disease Relevance 1.28 Pain Relevance 0.35
To our knowledge, this is the first report that serum IL-12 level was elevated in patients with AMI but not in patients with UAP.
Positive_regulation (elevated) of IL-12 associated with angina and myocardial infarction
4) Confidence 0.20 Published 2001 Journal J. Atheroscler. Thromb. Section Abstract Doc Link 11686313 Disease Relevance 1.23 Pain Relevance 0.58
, IL-12 and NO in LPS-stimulated macrophages.
Positive_regulation (stimulated) of IL-12 in macrophages
5) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0.05
However, LPS stimulates activation of additional immune mediators, including IL-6 [22], IL-12 [23], MCP-1 [24], and IL-8 [25].
Positive_regulation (activation) of IL-12
6) Confidence 0.07 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000109 Disease Relevance 0.14 Pain Relevance 0.08

General Comments

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