INT85885

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.74
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SNAP25) small molecule metabolic process (SNAP25) plasma membrane (SNAP25)
cytoplasm (SNAP25)
Anatomy Link Frequency
neurons 2
nerve 1
vesicles 1
SNAP25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Root ganglion neuron 6 99.50 Very High Very High Very High
headache 4 99.36 Very High Very High Very High
substance P 8 98.82 Very High Very High Very High
qutenza 16 98.20 Very High Very High Very High
Pain 14 91.64 High High
tetrodotoxin 12 90.72 High High
Botox 62 88.08 High High
Piles 23 77.60 Quite High
Neuropeptide 2 67.80 Quite High
Calcium channel 3 64.96 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 6 99.44 Very High Very High Very High
Headache 4 99.36 Very High Very High Very High
Ganglion Cysts 6 99.34 Very High Very High Very High
Clostridium Infection 2 95.32 Very High Very High Very High
Pain 9 91.64 High High
Muscular Spasm 4 91.28 High High
Anorectal Disorders 25 77.60 Quite High
Obesity 19 75.44 Quite High
Skin Appendage Disease 2 73.72 Quite High
Ovarian Cancer 33 71.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Schizophrenic subjects had significantly elevated levels of SNAP-25 as compared to headache and control subjects.
Positive_regulation (elevated) of SNAP-25 associated with headache and schizophrenia
1) Confidence 0.69 Published 1999 Journal Neuropsychopharmacology Section Abstract Doc Link 10633477 Disease Relevance 0.71 Pain Relevance 0.19
It is concluded that capsaicin induces release of substance P from dorsal root ganglion neurons via two mechanisms, one requiring extracellular Ca(2+) and the intact synaptosomal-associated protein 25 kDa (SNAP-25), and the other independent of extracellular Ca(2+) and not involving SNAP-25.
Positive_regulation (requiring) of SNAP-25 in neurons associated with ganglion cysts, qutenza, root ganglion neuron and substance p
2) Confidence 0.48 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10751549 Disease Relevance 0.25 Pain Relevance 0.88
RESULTS: Mu opiate receptor gene expression was significantly down regulated in cells treated with SNAP at 30 min, and superoxide dismutase blocked the effect of SNAP.
Positive_regulation (effect) of SNAP
3) Confidence 0.46 Published 2001 Journal Med. Sci. Monit. Section Body Doc Link 11687719 Disease Relevance 0 Pain Relevance 0
It is concluded that capsaicin induces release of substance P from dorsal root ganglion neurons via two mechanisms, one requiring extracellular Ca(2+) and the intact synaptosomal-associated protein 25 kDa (SNAP-25), and the other independent of extracellular Ca(2+) and not involving SNAP-25.
Positive_regulation (requiring) of synaptosomal-associated protein 25 kDa in neurons associated with ganglion cysts, qutenza, root ganglion neuron and substance p
4) Confidence 0.42 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10751549 Disease Relevance 0.25 Pain Relevance 0.88
RT-PCR analysis demonstrated that the mRNA levels encoding for ABCG2, nestin, Tuj1, MAP2, NFL, NFM, NSE, GAP43, SNAP25, GFAP, and CNPase were also highly increased in NI-hADSCs.
Positive_regulation (increased) of SNAP25
5) Confidence 0.37 Published 2010 Journal BMC Cell Biol Section Abstract Doc Link PMC2867791 Disease Relevance 0.28 Pain Relevance 0.24
The authenticity of the spectra was verified using S-nitroso-N-acetylpenicillamine (SNAP, 100 ?
Positive_regulation (acetylpenicillamine) of SNAP
6) Confidence 0.09 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 0.07 Pain Relevance 0
The intracellular target of BTX-A is the SNAP-25 (synaptosome-associated protein of molecular eight 25 kD) which is a protein essential for the successful docking and release of acetylcholine vesicles with the presynaptic vesicle.17 In contrast, BTX-B cleaves VAMP (vesicle associated membrane protein), which is also known as synaptoabrevin.18 Like SNAP-25, VAMP is essential for the docking and fusion of the synaptic vesicles to the presynaptic membrane for the release of acetylcholine.


Positive_regulation (essential) of SNAP-25 in vesicles
7) Confidence 0.05 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943226 Disease Relevance 0 Pain Relevance 0.18
BTX A cleaves SNAP-25, a part of the SNARE complex that is responsible for acetylcholine transport from the nerve to the muscle end plate.
Positive_regulation (cleaves) of SNAP-25 in nerve
8) Confidence 0.03 Published 2008 Journal Journal of Cutaneous and Aesthetic Surgery Section Body Doc Link PMC2840903 Disease Relevance 1.19 Pain Relevance 0.46

General Comments

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