INT8589

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 14
Total Number 18
Disease Relevance 7.85
Pain Relevance 10.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
joints 6
knee joints 4
spinal 4
nerve 4
visceral 2
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 204 100.00 Very High Very High Very High
substance P 65 100.00 Very High Very High Very High
Dorsal horn 16 99.96 Very High Very High Very High
Thermal hyperalgesia 17 99.92 Very High Very High Very High
addiction 2 99.92 Very High Very High Very High
agonist 9 99.90 Very High Very High Very High
dorsal root ganglion 535 99.84 Very High Very High Very High
qutenza 19 99.84 Very High Very High Very High
Inflammation 186 99.60 Very High Very High Very High
Spinal cord 28 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 30 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 6 100.00 Very High Very High Very High
Hyperalgesia 63 99.92 Very High Very High Very High
Ganglion Cysts 535 99.84 Very High Very High Very High
INFLAMMATION 175 99.60 Very High Very High Very High
Neuropathic Pain 3 98.70 Very High Very High Very High
Neurogenic Inflammation 8 96.88 Very High Very High Very High
Hypersensitivity 3 95.52 Very High Very High Very High
Arthritis 150 92.20 High High
Headache 5 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results provide direct evidence suggesting that the spinal substance P-induced thermal hyperalgesia is mediated by an increase in spinal prostaglandin E2 via activation of the neurokinin 1 receptor.
Positive_regulation (mediated) of Positive_regulation (activation) of neurokinin 1 receptor in spinal associated with thermal hyperalgesia and substance p
1) Confidence 0.69 Published 1999 Journal Neuroscience Section Abstract Doc Link 10077333 Disease Relevance 0.49 Pain Relevance 1.23
Instead, D-SP(1-7) prevented the upregulation of NK-1 receptor immunoreactivity that was induced by capsaicin injected intrathecally, suggesting that the effect of capsaicin is also mediated by SP N-terminal metabolites.
Positive_regulation (induced) of Positive_regulation (upregulation) of NK-1 receptor associated with qutenza and substance p
2) Confidence 0.63 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12169105 Disease Relevance 0.27 Pain Relevance 1.94
Increased NK-1R mRNA levels could result from increased mRNA stability or an increased rate of NK-1R mRNA transcription.
Positive_regulation (result) of Positive_regulation (result) of NK-1R mRNA
3) Confidence 0.50 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8913350 Disease Relevance 0.17 Pain Relevance 0.20
Levels of the NK-1R pre-mRNA containing both introns A and B were significantly increased 1 hr after formalin treatment, and levels of NK-1R pre-mRNAs containing intron A were significantly elevated at 2 hr after formalin treatment.
Positive_regulation (increased) of Positive_regulation (increased) of NK-1R
4) Confidence 0.50 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8913350 Disease Relevance 0.30 Pain Relevance 0.24
Thus, activation of the NK-1R during nociception increases dorsal horn NK-1R mRNA levels through activation of transcriptional or splicing mechanisms.
Positive_regulation (increases) of Positive_regulation (activation) of NK-1R in dorsal horn associated with nociception and dorsal horn
5) Confidence 0.50 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8913350 Disease Relevance 0.32 Pain Relevance 0.32
These results show that acute noxious visceral stimuli induce activation of spinal lamina I neurons expressing the SPR and, that after visceral inflammation, there is a marked increase in both the number and rostrocaudal extent of lamina I SPR neurons activated in response to both normally non-noxious and noxious distention of the colon.
Positive_regulation (increase) of Positive_regulation (increase) of SPR in visceral associated with inflammation
6) Confidence 0.50 Published 2002 Journal J Pain Section Abstract Doc Link 14622848 Disease Relevance 0.57 Pain Relevance 0.47
Activation of the neurokinin-1 receptor by substance P during chronic nociception increases neurokinin-1 receptor gene expression in the spinal cord.
Positive_regulation (increases) of Positive_regulation (Activation) of neurokinin-1 receptor in spinal cord associated with nociception, spinal cord and substance p
7) Confidence 0.50 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430499 Disease Relevance 0.42 Pain Relevance 0.44
These results suggest that in the neonatal rat spinal cord, application of exogenous tachykinin agonists can induce ventral root depolarization by activation of neurokinin-1 and/or neurokinin-3 receptors.
Positive_regulation (induce) of Positive_regulation (activation) of neurokinin-1 in ventral root associated with agonist and spinal cord
8) Confidence 0.48 Published 1992 Journal Neuroscience Section Abstract Doc Link 1375709 Disease Relevance 0 Pain Relevance 0.55
Characteristics of nerve growth factor induced hyperalgesia in adult rats: dependence on enhanced bradykinin-1 receptor activity but not neurokinin-1 receptor activation.
Positive_regulation (enhanced) of Positive_regulation (activation) of neurokinin-1 receptor in nerve associated with addiction, hyperalgesia, nerve growth factor and bradykinin
9) Confidence 0.47 Published 1996 Journal Pain Section Title Doc Link 8880860 Disease Relevance 0.77 Pain Relevance 0.99
Characteristics of nerve growth factor induced hyperalgesia in adult rats: dependence on enhanced bradykinin-1 receptor activity but not neurokinin-1 receptor activation.
Positive_regulation (enhanced) of Positive_regulation (activation) of neurokinin-1 receptor in nerve associated with addiction, hyperalgesia, nerve growth factor and bradykinin
10) Confidence 0.34 Published 1996 Journal Pain Section Title Doc Link 8880860 Disease Relevance 0.77 Pain Relevance 0.99
Nerve growth factor induces mechanical allodynia associated with novel A fibre-evoked spinal reflex activity and enhanced neurokinin-1 receptor activation in the rat.
Positive_regulation (enhanced) of Positive_regulation (activation) of neurokinin-1 receptor in spinal associated with allodynia and nerve growth factor
11) Confidence 0.34 Published 1995 Journal Pain Section Title Doc Link 8545148 Disease Relevance 0.28 Pain Relevance 0.78
Like capsaicin, formalin and the aromatic compounds at least partially caused skin microvascular leakage, which was due to tachykinin NK1 receptor activation related to the release of tachykinins from the sensory nerve endings.
Positive_regulation (due) of Positive_regulation (activation) of tachykinin NK1 receptor in skin associated with qutenza
12) Confidence 0.29 Published 2009 Journal Toxicology Section Abstract Doc Link 19014991 Disease Relevance 0 Pain Relevance 0.46
Although FLS cells from both acutely and chronically inflamed joints produced elevated levels of PGE2, only the upregulation of NK1 receptor-like IR by FLS cells from acutely inflamed joints was prevented by indomethacin, suggesting that prostaglandins and/or other COX products are relevant mediators for receptor regulation in acute arthritis but not in chronic arthritis.
Positive_regulation (elevated) of Positive_regulation (upregulation) of NK1 receptor in joints associated with arthritis
13) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.43 Pain Relevance 0.28
However, indomethacin did not prevent upregulation of NK1 receptor-like IR in co-cultures with FLS cells from chronically inflamed knee joints, consistent with the finding that the supernatant from FLS cells from chronically inflamed knee joints did not induce upregulation of NK1 receptor-like IR.
Neg (not) Positive_regulation (induce) of Positive_regulation (upregulation) of NK1 receptor in knee joints
14) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.38 Pain Relevance 0.22
It is unclear why the supernatant of FLS cells from chronically inflamed joints did not induce NK1 receptor upregulation.
Neg (not) Positive_regulation (induce) of Neg (not) Positive_regulation (upregulation) of NK1 receptor in joints
15) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.47 Pain Relevance 0.43
Unlike the presence of FLS cells from chronically inflamed joints, the supernatant of FLS cells from chronically inflamed joints did not cause NK1 receptor upregulation, nor was upregulation reduced by indomethacin.
Neg (not) Positive_regulation (cause) of Neg (not) Positive_regulation (upregulation) of NK1 receptor in joints
16) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.34 Pain Relevance 0.23
Thus, FLS cells isolated from both acutely and chronically inflamed knee joints induced an upregulation of the NK1 receptor in DRG neurones from normal rats whereas a co-culture with FLS cells from normal knee joints did not.
Positive_regulation (induced) of Positive_regulation (upregulation) of NK1 receptor in knee joints associated with dorsal root ganglion
17) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 1.03 Pain Relevance 0.74
The release of tachykinins and endothelin-3 (ET-3) from trigeminal neurons induces dural vascular permeability and vasodilatation via activation of tachykinin receptor 1 (Tacr1) and endothelin receptor type B (Ednrb) on endothelial cells.
Positive_regulation (induces) of Positive_regulation (activation) of tachykinin receptor 1 in endothelial cells associated with increased venous pressure under development
18) Confidence 0.06 Published 2005 Journal Mol. Interv. Section Abstract Doc Link 16249526 Disease Relevance 0.84 Pain Relevance 0.35

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