INT8590

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Context Info
Confidence 0.62
First Reported 1992
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.43
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
spinal cord 2
motoneurons 2
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 20 100.00 Very High Very High Very High
Opioid 5 100.00 Very High Very High Very High
Pain threshold 3 100.00 Very High Very High Very High
Central grey 2 99.84 Very High Very High Very High
antagonist 7 99.26 Very High Very High Very High
Inflammation 33 99.08 Very High Very High Very High
Spinal cord 12 98.88 Very High Very High Very High
agonist 5 95.80 Very High Very High Very High
dorsal root ganglion 107 94.80 High High
Dorsal horn 10 80.56 Quite High
Disease Link Frequency Relevance Heat
Nociception 15 100.00 Very High Very High Very High
Pain 12 100.00 Very High Very High Very High
Urological Neuroanatomy 3 99.84 Very High Very High Very High
INFLAMMATION 33 99.08 Very High Very High Very High
Ganglion Cysts 107 94.80 High High
Inflammatory Pain 3 20.72 Low Low
Hyperalgesia 6 18.96 Low Low
Arthritis 30 5.00 Very Low Very Low Very Low
Arthralgia 3 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of rats with the selective NK-1R antagonist LY306,740 was used to determine the role of NK-1R activation in the regulation of nociception-induced NK-1R mRNA levels.
Regulation (regulation) of Positive_regulation (induced) of NK-1R mRNA associated with nociception and antagonist
1) Confidence 0.62 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8913350 Disease Relevance 0.32 Pain Relevance 0.26
Pretreatment of rats with the selective NK-1R antagonist LY306,740 was used to determine the role of NK-1R activation in the regulation of nociception-induced NK-1R mRNA levels.
Spec (determine) Regulation (role) of Spec (determine) Positive_regulation (activation) of NK-1R associated with nociception and antagonist
2) Confidence 0.45 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8913350 Disease Relevance 0.32 Pain Relevance 0.23
The response to stimulation of neurokinin-1 receptors has a major component likely to be due to a direct action at motoneurons.
Regulation (response) of Positive_regulation (stimulation) of neurokinin-1 in motoneurons
3) Confidence 0.43 Published 1992 Journal Neuroscience Section Abstract Doc Link 1375709 Disease Relevance 0 Pain Relevance 0.52
Rather than assaying SP release, in the present study we examined the effect of opioids on two postsynaptic measures of SP release, Fos expression and neurokinin-1 (NK-1) receptor internalization, in the rat.
Spec (examined) Regulation (effect) of Spec (examined) Positive_regulation (measures) of neurokinin-1 associated with opioid and substance p
4) Confidence 0.43 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10531466 Disease Relevance 0.19 Pain Relevance 0.98
Together, these data indicate a crucial role of prostaglandins in NK1 receptor upregulation at the acute stage of inflammation.
Regulation (role) of Positive_regulation (upregulation) of NK1 receptor associated with inflammation
5) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.40 Pain Relevance 0.26
Effects of intra-hippocampal injection of interleukin-2 on pain threshold and formaldehyde-induced substance P-like immunoreactivity in periaqueductal gray and spinal cord.
Regulation (Effects) of Positive_regulation (induced) of substance P-like immunoreactivity in spinal cord associated with pain threshold, central grey, spinal cord and substance p
6) Confidence 0.03 Published 1999 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 11245094 Disease Relevance 0.20 Pain Relevance 0.48

General Comments

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