INT85909

Context Info Confidence 0.00 First Reported 1999 Last Reported 1999 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.32

extracellular space (GREM1) extracellular region (GREM1) cell-cell signaling (GREM1) signal transducer activity (Oprm1)

Oprm1 (Rattus norvegicus) GREM1 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 3 100.00 Opioid 2 100.00

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The selective recognition of the aminoterminal binding pharmacophore Tyr-D-Xaa-Phe of the opioid heptapeptide dermorphin, Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 (DRM)1, and of dermenkephalin, Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2 (DREK), by the mu-opioid receptor and delta-opioid receptor, respectively, depends upon the constitution / conformation of the C-terminal tripeptide.

mu-opioid receptor Binding (recognition) of DRM associated with opioid receptor and opioid

1) Confidence 0.00 Published 1999 Journal J. Biomol. Struct. Dyn. Section Abstract Doc Link 10636080 Disease Relevance 0 Pain Relevance 0.32

General Comments

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