INT85938

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.19
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIK1) transport (GRIK1) plasma membrane (GRIK1)
Anatomy Link Frequency
neuronal 1
nerve 1
GRIK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
excitatory amino acid 16 100.00 Very High Very High Very High
ischemia 1 99.32 Very High Very High Very High
antagonist 2 99.04 Very High Very High Very High
Inflammation 2 98.72 Very High Very High Very High
halothane 6 98.28 Very High Very High Very High
Lasting pain 2 96.16 Very High Very High Very High
Perioperative pain 2 96.00 Very High Very High Very High
cocaine 7 92.40 High High
tetrodotoxin 8 91.80 High High
Dorsal horn 6 88.60 High High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 1 99.68 Very High Very High Very High
INFLAMMATION 2 98.72 Very High Very High Very High
Injury 2 97.64 Very High Very High Very High
Pain 2 96.16 Very High Very High Very High
Post Operative Pain 2 96.00 Very High Very High Very High
Congenital Anomalies 2 92.80 High High
Increased Venous Pressure Under Development 1 92.08 High High
Nociception 4 91.28 High High
Cognitive Disorder 2 90.76 High High
Depression 1 63.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These EAA antagonists can prevent neuronal damage that is due to the release of EAA during cerebral ischemia induced by stimulant use.
Localization (release) of EAA in neuronal associated with cv general 4 under development, ischemia, antagonist and excitatory amino acid
1) Confidence 0.58 Published 1999 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 10637824 Disease Relevance 0.49 Pain Relevance 1.11
Thus, the EAA release required an intact afferent nerve barrage and segmental excitatory nerve transmission.
Localization (release) of EAA in nerve
2) Confidence 0.03 Published 2002 Journal Pain Section Abstract Doc Link 12435460 Disease Relevance 0.23 Pain Relevance 0.82
This profile of EAA release further explains why models of inflammation and chemical irritation do not translate well to human postoperative pain.
Localization (release) of EAA associated with inflammation and perioperative pain
3) Confidence 0.03 Published 2002 Journal Pain Section Abstract Doc Link 12435460 Disease Relevance 0.47 Pain Relevance 0.75

General Comments

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