INT8594

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Context Info
Confidence 0.57
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.47
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mapt) cytoskeleton (Mapt) nucleus (Mapt)
enzyme binding (Mapt) cytoplasm (Mapt)
Anatomy Link Frequency
cleavage 1
Mapt (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 2 97.70 Very High Very High Very High
substance P 1 97.20 Very High Very High Very High
excitatory amino acid 2 96.60 Very High Very High Very High
Antinociceptive 5 92.56 High High
narcan 2 91.32 High High
antagonist 2 90.96 High High
opiate 2 90.52 High High
antinociception 1 76.64 Quite High
intrathecal 1 75.00 Quite High
Endogenous opioid 1 74.72 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 52 99.84 Very High Very High Very High
Targeted Disruption 18 99.52 Very High Very High Very High
Tauopathy 28 97.00 Very High Very High Very High
Dementia 36 96.48 Very High Very High Very High
Disease 349 94.96 High High
Cognitive Disorder 36 82.96 Quite High
Disease Progression 15 81.28 Quite High
Lumbar Puncture Related Headaches 6 60.32 Quite High
Frailty 11 48.52 Quite Low
Amyloid Plaque 40 48.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, experimental decrease of the level of Tau in amyloid transgenic mice can actually ameliorate several clinical symptoms and defects [27].
Negative_regulation (decrease) of Tau associated with targeted disruption and alzheimer's dementia
1) Confidence 0.57 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2938448 Disease Relevance 1.51 Pain Relevance 0
The inhibitory effects of both Tau and Ca+2 on the biting and scratching behaviors behaviors induced by substance P or excitatory amino acids were reversed by TAG, suggesting a common mediation by Tau.
Negative_regulation (effects) of Tau associated with excitatory amino acid and substance p
2) Confidence 0.42 Published 1992 Journal Life Sci. Section Abstract Doc Link 1375974 Disease Relevance 0 Pain Relevance 0.83
As a control we showed that the reaction of hPSASf with two known PSA substrates, alanine 4-methoxy-2-naphthylamide (Ala-4-MNA) and Leu-enkephalin, was completely inhibited by bestatin and puromycin under the same conditions in which these inhibitors failed to inhibit Tau cleavage, (Table 2).
Negative_regulation (inhibit) of Tau in cleavage associated with enkephalin
3) Confidence 0.42 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0.10
Moreover, a combination of more than one biomarker in CSF, such as CSF p-tau, t-tau, and A?
Negative_regulation (biomarker) of p-tau
4) Confidence 0.12 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.48 Pain Relevance 0.03
Moreover, a combination of more than one biomarker in CSF, such as CSF p-tau, t-tau, and A?
Negative_regulation (biomarker) of t-tau
5) Confidence 0.12 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.49 Pain Relevance 0.03

General Comments

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