INT85947

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.40
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cckar) endoplasmic reticulum (Cckar) plasma membrane (Cckar)
lysosome (Cckar) cytoplasm (Cckar) signal transducer activity (Cckar)
Anatomy Link Frequency
visceral 1
Cckar (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 14 100.00 Very High Very High Very High
anesthesia 3 100.00 Very High Very High Very High
Analgesic 1 100.00 Very High Very High Very High
antagonist 7 99.96 Very High Very High Very High
Morphine 17 99.36 Very High Very High Very High
antinociception 9 99.00 Very High Very High Very High
Visceral pain 1 97.80 Very High Very High Very High
Inflammation 12 87.44 High High
intrathecal 2 77.16 Quite High
Antinociceptive 8 75.44 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.96 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 97.80 Very High Very High Very High
Metabolic Disorder 9 97.12 Very High Very High Very High
Obesity 32 96.16 Very High Very High Very High
Diabetes Mellitus 20 95.56 Very High Very High Very High
Hyperphagia 1 94.84 High High
Nociception 1 90.04 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 89.52 High High
INFLAMMATION 12 87.44 High High
Sprains And Strains 17 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of cholecystokinin (CCK-8) and the CCK receptor antagonist proglumide, on antinociception induced by local peripheral (subcutaneous) injected morphine in non-diabetic (ND) and streptozotocin-induced diabetic (D) rats, were examined by means of the formalin test.
Spec (examined) Regulation (effects) of CCK receptor associated with antinociception, diabetes mellitus, antagonist, cholecystokinin and morphine
1) Confidence 0.36 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17157334 Disease Relevance 0.58 Pain Relevance 0.94
Effects of spinal cholecystokinin receptor antagonists on morphine antinociception in a model of visceral pain in the rat.
Regulation (Effects) of cholecystokinin receptor in visceral associated with antinociception, visceral pain, analgesic, antagonist, cholecystokinin and morphine
2) Confidence 0.33 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10640290 Disease Relevance 0.23 Pain Relevance 1.70
The OLETF rat is a spontaneous cholecystokinin-1 receptor knock out model possessing defects in the satiety action of cholecystokinin [25,26].
Regulation (spontaneous) of cholecystokinin-1 receptor associated with targeted disruption and cholecystokinin
3) Confidence 0.15 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 1.31 Pain Relevance 0.23

General Comments

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