INT8595

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Context Info
Confidence 0.73
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 6.81
Pain Relevance 6.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mapt) cytoskeleton (Mapt) nucleus (Mapt)
enzyme binding (Mapt) cytoplasm (Mapt)
Anatomy Link Frequency
hippocampal formation 2
spinal cord 2
striatum 2
brainstem 2
central nervous system 2
Mapt (Mus musculus)
Pain Link Frequency Relevance Heat
Endogenous opioid 1 99.84 Very High Very High Very High
Central nervous system 266 99.00 Very High Very High Very High
Antinociceptive 5 98.52 Very High Very High Very High
Thalamus 66 94.96 High High
Substantia nigra 110 94.56 High High
medulla 44 93.28 High High
excitatory amino acid 2 92.84 High High
Spinal cord 220 92.08 High High
substance P 1 91.80 High High
narcan 2 79.12 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1315 99.68 Very High Very High Very High
Tauopathy 28 99.56 Very High Very High Very High
Death 12 96.28 Very High Very High Very High
Amyloid Plaque 24 94.88 High High
Disease 190 93.44 High High
Alzheimer's Dementia 42 87.36 High High
Dementia 20 75.80 Quite High
Sclerosis 2 73.92 Quite High
Neurodegenerative Disease 9 70.64 Quite High
Cognitive Disorder 22 66.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that the antinociceptive effects of both Tau and Ca+2 appear to be mediated, at least in part, by Tau but not by the release of endogenous opioid compounds.
Localization (release) of Tau associated with endogenous opioid and antinociceptive
1) Confidence 0.73 Published 1992 Journal Life Sci. Section Abstract Doc Link 1375974 Disease Relevance 0 Pain Relevance 0.80
We proposed that neurons affected by Tauopathy can either engage in aggregation of Tau and thereby try to decrease the toxic species and hope to survive, or to enter the “path to death” by failing to aggregate protein Tau [11].
Localization (aggregation) of Tau in neurons associated with tauopathy and death
2) Confidence 0.73 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2938448 Disease Relevance 0.66 Pain Relevance 0
Tau is synthesized within the neuron and localized in the axon where it promotes stability and assembly of microtubules [6].
Localization (localized) of Tau in neuron
3) Confidence 0.73 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.36 Pain Relevance 0
We found that the hPSASf dependent cleavage of Tau was not blocked by the aminopeptidase inhibitors bestatin and puromycin, but was inhibited by the metal chelator o-phenanthroline (figure 3).
Localization (cleavage) of Tau in cleavage
4) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0.07
Although both tau/LacZ and tau/GFP reporters were widely distributed in various CNS regions such as the piriform cortex, olfactory bulb, striatum, hippocampal formation, thalamus, substantia nigra, hypothalamus, brainstem, purkinje cells and spinal cord, the distribution patterns of the two reporters differed in certain brain regions.
Localization (reporters) of tau/LacZ in olfactory bulb associated with medulla, substantia nigra, thalamus, central nervous system and spinal cord
5) Confidence 0.10 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.18 Pain Relevance 0.26
Distribution of tau/LacZ and tau/GFP reporters in the transgenic mouse central nervous system
Localization (reporters) of tau/GFP in central nervous system associated with targeted disruption and central nervous system
6) Confidence 0.10 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.59 Pain Relevance 0.12
Distribution of tau/LacZ and tau/GFP reporters in the transgenic mouse central nervous system
Localization (reporters) of tau/LacZ in central nervous system associated with targeted disruption and central nervous system
7) Confidence 0.10 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.59 Pain Relevance 0.12
Although both tau/LacZ and tau/GFP reporters were widely distributed in various CNS regions such as the piriform cortex, olfactory bulb, striatum, hippocampal formation, thalamus, substantia nigra, hypothalamus, brainstem, purkinje cells and spinal cord, the distribution patterns of the two reporters differed in certain brain regions.
Localization (reporters) of tau/GFP in olfactory bulb associated with medulla, substantia nigra, thalamus, central nervous system and spinal cord
8) Confidence 0.10 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.18 Pain Relevance 0.26
Although both tau/LacZ and tau/GFP reporters were widely distributed in various CNS regions such as the piriform cortex, olfactory bulb, striatum, hippocampal formation, thalamus, substantia nigra, hypothalamus, brainstem, purkinje cells and spinal cord, the distribution patterns of the two reporters differed in certain brain regions.
Localization (reporters) of tau/GFP in piriform cortex associated with medulla, substantia nigra, thalamus, central nervous system and spinal cord
9) Confidence 0.03 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.18 Pain Relevance 0.26
Although both tau/LacZ and tau/GFP reporters were widely distributed in various CNS regions such as the piriform cortex, olfactory bulb, striatum, hippocampal formation, thalamus, substantia nigra, hypothalamus, brainstem, purkinje cells and spinal cord, the distribution patterns of the two reporters differed in certain brain regions.
Localization (reporters) of tau/LacZ in purkinje cells associated with medulla, substantia nigra, thalamus, central nervous system and spinal cord
10) Confidence 0.03 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.18 Pain Relevance 0.26
Although both tau/LacZ and tau/GFP reporters were widely distributed in various CNS regions such as the piriform cortex, olfactory bulb, striatum, hippocampal formation, thalamus, substantia nigra, hypothalamus, brainstem, purkinje cells and spinal cord, the distribution patterns of the two reporters differed in certain brain regions.
Localization (reporters) of tau/LacZ in spinal cord associated with medulla, substantia nigra, thalamus, central nervous system and spinal cord
11) Confidence 0.03 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.18 Pain Relevance 0.26
Although both tau/LacZ and tau/GFP reporters were widely distributed in various CNS regions such as the piriform cortex, olfactory bulb, striatum, hippocampal formation, thalamus, substantia nigra, hypothalamus, brainstem, purkinje cells and spinal cord, the distribution patterns of the two reporters differed in certain brain regions.
Localization (reporters) of tau/LacZ in substantia nigra associated with medulla, substantia nigra, thalamus, central nervous system and spinal cord
12) Confidence 0.03 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.18 Pain Relevance 0.26
Although both tau/LacZ and tau/GFP reporters were widely distributed in various CNS regions such as the piriform cortex, olfactory bulb, striatum, hippocampal formation, thalamus, substantia nigra, hypothalamus, brainstem, purkinje cells and spinal cord, the distribution patterns of the two reporters differed in certain brain regions.
Localization (reporters) of tau/GFP in spinal cord associated with medulla, substantia nigra, thalamus, central nervous system and spinal cord
13) Confidence 0.03 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.18 Pain Relevance 0.26
Although both tau/LacZ and tau/GFP reporters were widely distributed in various CNS regions such as the piriform cortex, olfactory bulb, striatum, hippocampal formation, thalamus, substantia nigra, hypothalamus, brainstem, purkinje cells and spinal cord, the distribution patterns of the two reporters differed in certain brain regions.
Localization (reporters) of tau/GFP in thalamus associated with medulla, substantia nigra, thalamus, central nervous system and spinal cord
14) Confidence 0.03 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.18 Pain Relevance 0.26
Although both tau/LacZ and tau/GFP reporters were widely distributed in various CNS regions such as the piriform cortex, olfactory bulb, striatum, hippocampal formation, thalamus, substantia nigra, hypothalamus, brainstem, purkinje cells and spinal cord, the distribution patterns of the two reporters differed in certain brain regions.
Localization (reporters) of tau/LacZ in piriform cortex associated with medulla, substantia nigra, thalamus, central nervous system and spinal cord
15) Confidence 0.03 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.18 Pain Relevance 0.26
Although both tau/LacZ and tau/GFP reporters were widely distributed in various CNS regions such as the piriform cortex, olfactory bulb, striatum, hippocampal formation, thalamus, substantia nigra, hypothalamus, brainstem, purkinje cells and spinal cord, the distribution patterns of the two reporters differed in certain brain regions.
Localization (reporters) of tau/LacZ in hippocampal formation associated with medulla, substantia nigra, thalamus, central nervous system and spinal cord
16) Confidence 0.03 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.18 Pain Relevance 0.26
Although both tau/LacZ and tau/GFP reporters were widely distributed in various CNS regions such as the piriform cortex, olfactory bulb, striatum, hippocampal formation, thalamus, substantia nigra, hypothalamus, brainstem, purkinje cells and spinal cord, the distribution patterns of the two reporters differed in certain brain regions.
Localization (reporters) of tau/GFP in hippocampal formation associated with medulla, substantia nigra, thalamus, central nervous system and spinal cord
17) Confidence 0.03 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.18 Pain Relevance 0.26
Although both tau/LacZ and tau/GFP reporters were widely distributed in various CNS regions such as the piriform cortex, olfactory bulb, striatum, hippocampal formation, thalamus, substantia nigra, hypothalamus, brainstem, purkinje cells and spinal cord, the distribution patterns of the two reporters differed in certain brain regions.
Localization (reporters) of tau/GFP in substantia nigra associated with medulla, substantia nigra, thalamus, central nervous system and spinal cord
18) Confidence 0.03 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.18 Pain Relevance 0.26
Although both tau/LacZ and tau/GFP reporters were widely distributed in various CNS regions such as the piriform cortex, olfactory bulb, striatum, hippocampal formation, thalamus, substantia nigra, hypothalamus, brainstem, purkinje cells and spinal cord, the distribution patterns of the two reporters differed in certain brain regions.
Localization (reporters) of tau/LacZ in striatum associated with medulla, substantia nigra, thalamus, central nervous system and spinal cord
19) Confidence 0.03 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.18 Pain Relevance 0.26
Although both tau/LacZ and tau/GFP reporters were widely distributed in various CNS regions such as the piriform cortex, olfactory bulb, striatum, hippocampal formation, thalamus, substantia nigra, hypothalamus, brainstem, purkinje cells and spinal cord, the distribution patterns of the two reporters differed in certain brain regions.
Localization (reporters) of tau/LacZ in thalamus associated with medulla, substantia nigra, thalamus, central nervous system and spinal cord
20) Confidence 0.03 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.18 Pain Relevance 0.26

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