INT85952

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 14
Speculated 3
Reported most in Body
Documents 168
Total Number 171
Disease Relevance 64.36
Pain Relevance 20.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
nucleus 5
epithelial cells 2
bladder 2
mast cells 2
ZFL 1
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 1438 100.00 Very High Very High Very High
Potency 628 99.96 Very High Very High Very High
antagonist 484 99.96 Very High Very High Very High
Central nervous system 29 99.84 Very High Very High Very High
addiction 236 99.62 Very High Very High Very High
opioid receptor 21 99.56 Very High Very High Very High
Inflammatory mediators 127 99.36 Very High Very High Very High
hyperexcitability 75 99.28 Very High Very High Very High
Inflammatory response 167 99.24 Very High Very High Very High
diabetic neuropathy 14 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 694 100.00 Very High Very High Very High
Rhinitis 136 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 74 100.00 Very High Very High Very High
Muscular Atrophy 6 100.00 Very High Very High Very High
Cancer 1770 99.96 Very High Very High Very High
Obesity 50 99.92 Very High Very High Very High
Prostate Cancer 2370 99.86 Very High Very High Very High
Reprotox - General 1 948 99.84 Very High Very High Very High
Alopecia 306 99.80 Very High Very High Very High
Bordatella Infection 6 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A report by Chen et al showed that mere 3-fold increase in androgen receptor will confer prostate cancer cells resistance to antiandrogens by amplifying signal output from low levels of residual ligand, and by altering the normal response to antagonists [27].
Positive_regulation (increase) of androgen receptor in mere associated with antagonist and prostate cancer
1) Confidence 0.67 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.52 Pain Relevance 0.13
The wild type androgen receptor is unresponsive or only weakly activated by antiandrogens.
Positive_regulation (activated) of wild type androgen receptor
2) Confidence 0.67 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.72 Pain Relevance 0.07
Proliferation, expression of androgen-regulated genes, and transactivation of the androgen receptor (AR) were monitored in LNCaP human prostate cancer cells in response to OCM using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, Northern blot analysis, and reporter gene constructs.
Positive_regulation (transactivation) of androgen receptor
3) Confidence 0.63 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15014041 Disease Relevance 0.09 Pain Relevance 0
Proliferation, expression of androgen-regulated genes, and transactivation of the androgen receptor (AR) were monitored in LNCaP human prostate cancer cells in response to OCM using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, Northern blot analysis, and reporter gene constructs.
Positive_regulation (transactivation) of AR
4) Confidence 0.63 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15014041 Disease Relevance 0.09 Pain Relevance 0
Constitutive alpha(2A)-AR activation was mainly observed with the G(alphao) Cys(351)Ile protein compared with the pertussis toxin-resistant mutants of the G(alphai) protein subtypes.
Positive_regulation (activation) of AR associated with bordatella infection
5) Confidence 0.59 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10640303 Disease Relevance 0.10 Pain Relevance 0.31
In vitro hydroxyflutmamide induced rapid activation of ras/MAP kinase pathway in human prostate cancer DU145 cells (which lack the androgen receptor) as well as in CWR22 and PC-3AR2 androgen receptor positive cells lines, indicating that the activation did not require androgen receptor.
Neg (not) Positive_regulation (require) of androgen receptor associated with prostate cancer
6) Confidence 0.59 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.33 Pain Relevance 0.12
In conclusion, the present study shows that AR overexpression (in PC346Flu1) and mutation (in PC346Flu2) may allow for the maintenance of the AR activity under androgen ablation and antiandrogen treatment.
Positive_regulation (maintenance) of AR
7) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.06 Pain Relevance 0.05
This is particularly important in the context of castrate-resistant PCa, where AR activation can occur through various signaling pathways, including Her2, AKT, and MAPK [25].


Positive_regulation (activation) of AR associated with prostate cancer
8) Confidence 0.51 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.25 Pain Relevance 0
Severe complications including acute chest syndrome, congestive heart failure, pancreatitis, and acute renal failure were associated with DHTR/H syndrome in our patients.
Positive_regulation (syndrome) of DHTR in chest
9) Confidence 0.49 Published 2003 Journal Pediatrics Section Body Doc Link 12777582 Disease Relevance 0 Pain Relevance 0
It has also been suggested that antiandrogens may stimulate a non-androgen receptor pathway.
Spec (may) Positive_regulation (stimulate) of non-androgen receptor
10) Confidence 0.49 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2615041 Disease Relevance 0.35 Pain Relevance 0.15
Delta(9)-tetrahydrocannabinol inhibits 17beta-estradiol-induced proliferation and fails to activate androgen and estrogen receptors in MCF7 human breast cancer cells.
Neg (fails) Positive_regulation (activate) of androgen in MCF7 associated with breast cancer
11) Confidence 0.49 Published 2008 Journal Anticancer Res. Section Title Doc Link 18383828 Disease Relevance 0.19 Pain Relevance 0.10
Among them, eugenol had the highest AR antagonistic activity with its IC(50) value of 19 microM.
Positive_regulation (had) of AR
12) Confidence 0.47 Published 2010 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 20226658 Disease Relevance 0.19 Pain Relevance 0.13
In addition, while maximum AR was not affected, inducibility of AR was significantly lower (P < 0.004) and spontaneous AR increased (P < 0.02).
Positive_regulation (inducibility) of AR
13) Confidence 0.45 Published 2006 Journal World J Urol Section Abstract Doc Link 16404593 Disease Relevance 0.40 Pain Relevance 0.40
Clonal restriction of the neutrophil infiltrate was found in two of the patients with acute myelogenous leukemia; the other two patients were homozygous for the HUMARA gene, precluding analysis.
Positive_regulation (homozygous) of HUMARA in neutrophil associated with acute myeloid leukemia
14) Confidence 0.44 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1963326 Disease Relevance 0.88 Pain Relevance 0.07
The basal [(35)S]GTPgammaS binding response displayed a constitutive alpha(2A)-AR activity that amounted to 21% of the maximal receptor activation as obtained with 10 microM (-)-adrenaline.
Positive_regulation (activation) of AR
15) Confidence 0.40 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10640303 Disease Relevance 0 Pain Relevance 0.20
In contrast to this, determination of the trans-activation potential using the carp epithelioma papillosum cyprini cell line indicated that the efficiency of activation of the rainbow trout AR?
Positive_regulation (activation) of AR associated with carcinoma
16) Confidence 0.40 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1192819 Disease Relevance 0.10 Pain Relevance 0.04
In addition, while maximum AR was not affected, inducibility of AR was significantly lower (P < 0.004) and spontaneous AR increased (P < 0.02).
Positive_regulation (increased) of AR
17) Confidence 0.39 Published 2006 Journal World J Urol Section Abstract Doc Link 16404593 Disease Relevance 0.39 Pain Relevance 0.40
The role of AR in androgen-dependent prostate carcinomas has been well established over years, and recently confirmed using an inducible AR-shRNA lentiviral construct in LNCaP tumors [50].
Positive_regulation (inducible) of AR-shRNA associated with cancer and prostate cancer
18) Confidence 0.39 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994591 Disease Relevance 0.76 Pain Relevance 0
These results indicate that the gene expression differences observed are not largely explained by R1881 activating the AR transcriptional program in PC346C cells.
Positive_regulation (activating) of AR
19) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0 Pain Relevance 0
AR expression was shown to be maintained in the majority of patients that underwent hormonal therapy and showed recurrence of disease, suggesting a role of the AR also in late stage disease [4], [5].
Positive_regulation (role) of AR associated with disease and recurrence
20) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.00 Pain Relevance 0.06

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