INT85955

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Context Info
Confidence 0.48
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.05
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (G2e3) Golgi apparatus (G2e3) intracellular (G2e3)
cytoplasm (G2e3)
Anatomy Link Frequency
blood 2
G2e3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 4 97.80 Very High Very High Very High
antinociception 7 96.32 Very High Very High Very High
Morphine 20 95.44 Very High Very High Very High
Antinociceptive 3 88.48 High High
Intracerebroventricular 1 75.00 Quite High
opioid receptor 1 73.72 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 2 53.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, our data also indicate that chloramphenicol inhibited the biliary secretion of M3G.
Negative_regulation (inhibited) of Localization (secretion) of M3G
1) Confidence 0.48 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10640523 Disease Relevance 0 Pain Relevance 1.63
CONCLUSIONS: In STZ-diabetic rats, the distribution volume of morphine increased, the glucuronidation rate and M3G transportation into the blood were enhanced, and the excretion of M3G was decreased, leading to an increase in the plasma M3G concentration.


Negative_regulation (decreased) of Localization (excretion) of M3G in blood
2) Confidence 0.16 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20487213 Disease Relevance 0.05 Pain Relevance 0

General Comments

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