INT85963

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 9.00
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LIFR) plasma membrane (LIFR)
Anatomy Link Frequency
Notch 1
cones 1
neurons 1
epithelial cells 1
LIFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 253 100.00 Very High Very High Very High
primary somatosensory cortex 200 100.00 Very High Very High Very High
cytokine 356 93.76 High High
induced neuropathy 1 91.68 High High
cerebral cortex 16 84.16 Quite High
Pyramidal cell 1 75.40 Quite High
Nerve growth factor 4 73.32 Quite High
medulla 1 72.72 Quite High
Dopamine 88 52.96 Quite High
Inflammation 81 50.00 Quite Low
Disease Link Frequency Relevance Heat
Sleep Disorders 636 100.00 Very High Very High Very High
Carcinoma 96 99.52 Very High Very High Very High
Cancer 38 96.08 Very High Very High Very High
Neuropathic Pain 1 91.36 High High
Aids-related Complex 140 85.60 High High
Metaplasia 48 85.08 High High
Muscular Dystrophy 70 84.08 Quite High
Hypothyroidism 8 83.08 Quite High
Coma 2 78.40 Quite High
Sleep Initiation And Maintenance Disorders 22 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cloning and expression of the murine sws/NTE gene.
Gene_expression (expression) of sws
1) Confidence 0.75 Published 2000 Journal Mech. Dev. Section Title Doc Link 10640712 Disease Relevance 0.09 Pain Relevance 0.20
LIF receptor (LIFR) expression was induced by treating epithelial cells with growth medium containing 20 nM of the histone deacetylase inhibitor depsipeptide FR901228 (NCI) [22].


Gene_expression (expression) of LIFR in epithelial cells
2) Confidence 0.56 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.12 Pain Relevance 0.07
The expression of LIFR?
Gene_expression (expression) of LIFR
3) Confidence 0.56 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.64 Pain Relevance 0.05
Possible mechanisms are genetic and epigenetic changes [1,28] that lead to the inactivation of receptor genes such as silencing LIFR by DNA methylation [29] or enhanced expression of LIFR, OSMR, but reduced expression of IL-6R by acetylation of histone and transcription-controlling factors [22].
Gene_expression (expression) of LIFR
4) Confidence 0.56 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0 Pain Relevance 0.15
The re-expression of LIFR in various cell types is controlled by an epigenetic process that depends on histone acetylation within CpG islands of the LIFR promoter region [22].
Gene_expression (expression) of LIFR
5) Confidence 0.56 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.72 Pain Relevance 0.04
The treatment induced the expression of LIFR?
Gene_expression (expression) of LIFR
6) Confidence 0.56 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.71 Pain Relevance 0.04
A similar FR901228 treatment of the carcinoma cells further enhanced LIFR expression and LIF-dependent signaling (Fig. 6).
Gene_expression (expression) of LIFR associated with carcinoma
7) Confidence 0.56 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.59 Pain Relevance 0.03
Alternatively, the increase in drowsiness occurring during the light phase in migrating sparrows may have compensated for SWS loss during the previous night, thereby accounting for the absence of an increase in SWS-related SWA during the subsequent night.
Gene_expression (loss) of SWS associated with sleep disorders
8) Confidence 0.54 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.19 Pain Relevance 0
Precedent for the former is found in bottlenose dolphins (Tursiops truncates), northern fur seals (Callorhinus ursinus), and cape fur seals (Arctocephalus pussilus) that swim in a coordinated manner while exhibiting unihemispheric SWS, a state characterized by SWS-related EEG in one hemisphere and EEG indistinguishable from wakefulness in the other hemisphere (Mukhametov et al. 1977; Lyamin and Chetyrbok 1992; Rattenborg et al. 2000).
Gene_expression (exhibiting) of SWS
9) Confidence 0.54 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.24 Pain Relevance 0
Using a human Stem Cell Gene Array, we found that the CD133+CXCR4+CD34- sorted cells expressed genes reflective of vascular progenitors, including CD31, FZD 2/3/4/7, CXCR4, LIFR, and Notch promoter 1 (data not shown).
Gene_expression (expressed) of LIFR in Notch
10) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.39 Pain Relevance 0
SWA during SWS was also higher, during the first 4 hours after sleep deprivation, relative to SWA at the same circadian time in baseline.
Gene_expression (higher) of SWS associated with sleep disorders
11) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.96 Pain Relevance 0
During the first 2 hours of recovery, both drowsiness and SWS showed widespread increase in EEG power across most frequencies.
Gene_expression (drowsiness) of SWS associated with sleep disorders
12) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 1.13 Pain Relevance 0
The EEG power in the SWA range was significantly higher in SWS compared to waking, drowsiness, and REM sleep (Fig. 3B).
Gene_expression (sleep) of SWS associated with sleep disorders
13) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.62 Pain Relevance 0
Finally, peak SWA in both SWS and NREM sleep during the first 2 hours after sleep onset reached significantly higher levels during recovery relative to baseline (p < 0.05).
Gene_expression (sleep) of SWS
14) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.43 Pain Relevance 0
Finally, peak SWA in both SWS and NREM sleep during the first 2 hours after sleep onset reached significantly higher levels during recovery relative to baseline, indicating that at the beginning of baseline night SWA values were still below saturation.
Gene_expression (sleep) of SWS
15) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.58 Pain Relevance 0
Figure 3A shows the EEG power spectrum (0.5–25 Hz) during drowsiness, SWS and REM sleep expressed as percentage of the waking EEG spectrum.
Gene_expression (expressed) of SWS associated with sleep disorders
16) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.52 Pain Relevance 0
Next, we compared the mean firing rates of activated neurons in S1, HP, and V1 across WK, SWS, and REM sleep occurring between 2?
Gene_expression (neurons) of SWS in neurons associated with primary somatosensory cortex and hippocampus
17) Confidence 0.06 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0 Pain Relevance 0.18
Spindle-range LFP activity in itself is certainly not sufficient to induce IEG expression, or else SWS and IS would also lead to IEG upregulation, like REM sleep does.
Gene_expression (expression) of SWS
18) Confidence 0.06 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.16 Pain Relevance 0.07
Recent results in humans show that the duration of SWS recorded a few hours after memory acquisition correlates positively with cortical engagement and hippocampal disengagement in memory encoding over the course of the following month, but REM sleep has not been assessed (Takashima et al., 2006).
Gene_expression (duration) of SWS
19) Confidence 0.06 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0 Pain Relevance 0.06
minutes for SWS, 15?
Gene_expression (minutes) of SWS
20) Confidence 0.06 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.15 Pain Relevance 0.03

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