INT85964

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 109
Total Number 112
Disease Relevance 69.73
Pain Relevance 15.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pecam1) cell adhesion (Pecam1) plasma membrane (Pecam1)
Anatomy Link Frequency
platelet 17
blood vessels 11
endothelial cells 11
brains 3
vessels 3
Pecam1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 109 100.00 Very High Very High Very High
allodynia 12 100.00 Very High Very High Very High
Hippocampus 372 99.68 Very High Very High Very High
Arthritis 356 99.62 Very High Very High Very High
ischemia 883 99.40 Very High Very High Very High
cytokine 243 99.12 Very High Very High Very High
Inflammation 639 98.96 Very High Very High Very High
Spinal cord 74 98.94 Very High Very High Very High
cocaine 4 98.90 Very High Very High Very High
Dorsal horn 14 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 286 100.00 Very High Very High Very High
Neuropathic Pain 74 100.00 Very High Very High Very High
Systemic Sclerosis 34 100.00 Very High Very High Very High
Corneal Neovascularization 123 99.92 Very High Very High Very High
Stress 793 99.90 Very High Very High Very High
Myocardial Infarction 1427 99.72 Very High Very High Very High
Inflammatory Bowel Disease 18 99.72 Very High Very High Very High
Bites And Stings 5 99.72 Very High Very High Very High
Injury 398 99.68 Very High Very High Very High
Death 257 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of PECAM-1 was visualized by immunohistochemistry.
Gene_expression (Expression) of PECAM-1
1) Confidence 0.78 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17510197 Disease Relevance 0.89 Pain Relevance 0.20
PECAM-1 was expressed in colitic mice.
Gene_expression (expressed) of PECAM-1
2) Confidence 0.78 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17510197 Disease Relevance 1.01 Pain Relevance 0.24
The platelet-endothelial cell adhesion molecule-1 PECAM-1 (CD31) is expressed in the tight junction area of endothelial cells, where it is supposed to support the transmigration process.
Gene_expression (expressed) of CD31 in platelet associated with adhesions
3) Confidence 0.78 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17510197 Disease Relevance 0.68 Pain Relevance 0.17
However, to date there are no studies documenting the relationship between stress and PECAM-1 expression in the brain after an ischemic insult.
Gene_expression (expression) of PECAM-1 in brain associated with stress
4) Confidence 0.77 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 0.93 Pain Relevance 0.22
Differential spinal expression of major histocompatibility complex (MHC) class II, platelet-endothelial cellular adhesion molecule (PECAM), intercellular adhesion molecule (ICAM) and CD4 was observed in the two injury models.
Gene_expression (expression) of PECAM in platelet associated with injury and adhesions
5) Confidence 0.76 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960644 Disease Relevance 1.03 Pain Relevance 0.55
The platelet-endothelial cell adhesion molecule-1 PECAM-1 (CD31) is expressed in the tight junction area of endothelial cells, where it is supposed to support the transmigration process.
Gene_expression (expressed) of platelet-endothelial cell adhesion molecule-1 PECAM-1 in platelet associated with adhesions
6) Confidence 0.68 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17510197 Disease Relevance 0.69 Pain Relevance 0.17
Immunohistochemical staining for PECAM-1
Gene_expression (staining) of PECAM-1
7) Confidence 0.67 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 0.35 Pain Relevance 0.09
In the sham- and stress-sham-groups, PECAM-1 immunoreaction
Gene_expression (immunoreaction) of PECAM-1 associated with stress
8) Confidence 0.67 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.28 Pain Relevance 0.42
This result coincided with a previous study which reported that PECAM-1 immunoreactivity and protein levels were significantly increased in the hippocampal CA1 region 4 days after ischemia/reperfusion (Hwang et al., 2005).
Gene_expression (immunoreactivity) of PECAM-1 associated with ischemia
9) Confidence 0.67 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.20 Pain Relevance 0.30
Changes in PECAM-1 immunoreactivity
Gene_expression (Changes) of PECAM-1
10) Confidence 0.67 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.27 Pain Relevance 0.41
However, in this study, we observed that PECAM-1 immunoreactivity
Gene_expression (immunoreactivity) of PECAM-1
11) Confidence 0.67 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.05 Pain Relevance 0.37
To obtain the accurate data for PECAM-1 immunoreactivity,
Gene_expression (immunoreactivity) of PECAM-1
12) Confidence 0.67 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 0.35 Pain Relevance 0.09
Changes in PECAM-1 immunoreactivity
Gene_expression (immunoreactivity) of PECAM-1
13) Confidence 0.67 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.28 Pain Relevance 0.41
Differential spinal expression of major histocompatibility complex (MHC) class II, platelet-endothelial cellular adhesion molecule (PECAM), intercellular adhesion molecule (ICAM) and CD4 was observed in the two injury models.
Gene_expression (expression) of platelet-endothelial cellular adhesion molecule in platelet associated with injury and adhesions
14) Confidence 0.66 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960644 Disease Relevance 1.02 Pain Relevance 0.55
In conclusion, repeated restraint stress protected transient ischemia-induced neuronal death and maintained PECAM-1 immunoreactivity and protein levels in the hippocampus following ischemia/reperfusion.
Gene_expression (levels) of PECAM-1 in hippocampus associated with stress, ischemia, hippocampus and death
15) Confidence 0.60 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.31 Pain Relevance 0.45
This may be associated with neutrophil transmigration because PECAM-1 plays an important role in the adhesion cascade leading to leukocyte-endothelial transmigration and extravasation of PECAM-1 producing cells, such as neutrophils, monocytes, and lymphocytes during inflammation (Ilan & Madri, 2003; Kalinowska & Losy, 2006).
Gene_expression (producing) of PECAM-1 in monocytes associated with inflammation and adhesions
16) Confidence 0.60 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.10 Pain Relevance 0.34
As mentioned previously, inflammation and infiltration of inflammatory cells are thought to be important factors in ischemia-induced neuronal damage (Gautier et al., 2009; Hendryk et al., 2010); therefore, the fact that there were no significant changes in PECAM-1 immunoreactivity and protein levels in the stress-ischemia-group may be related to the blockade of inflammatory events such as infiltration of inflammatory cells.
Gene_expression (levels) of PECAM-1 in neuronal associated with stress, inflammation and ischemia
17) Confidence 0.60 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.58 Pain Relevance 0.53
In the western blot study, we found that changes in PECAM-1 protein levels in the gerbil hippocampus after ischemia/reperfusion were generally similar to the immunohistochemical change.
Gene_expression (levels) of PECAM-1 in hippocampus associated with ischemia and hippocampus
18) Confidence 0.60 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.56 Pain Relevance 0.62
They were next incubated with diluted mouse anti-PECAM-1 antibody (diluted 1 : 1,000, sc-1506, Santa Cruz Biotechnology, Santa Cruz, CA) overnight at 4?
Gene_expression (antibody) of anti-PECAM-1
19) Confidence 0.58 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 0.37 Pain Relevance 0.07
The Spearman Rank-order correlation between normalized numbers of newly created CD31 positive structures in matrigel and concentration of potentially angiogenic substances such as insulin, leptin, adiponectin glucose and lipids was performed.
Gene_expression (glucose) of CD31
20) Confidence 0.57 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.48 Pain Relevance 0

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