INT85965

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 16.76
Pain Relevance 4.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cd40lg) extracellular space (Cd40lg) extracellular region (Cd40lg)
plasma membrane (Cd40lg)
Anatomy Link Frequency
T cells 6
B cells 3
brain 1
bone marrow 1
plaques 1
Cd40lg (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 66 99.92 Very High Very High Very High
Cannabinoid 22 99.50 Very High Very High Very High
Inflammatory response 40 99.04 Very High Very High Very High
cytokine 277 98.88 Very High Very High Very High
Arthritis 177 98.64 Very High Very High Very High
Inflammation 230 97.84 Very High Very High Very High
Multiple sclerosis 28 94.68 High High
rheumatoid arthritis 133 91.60 High High
agonist 56 91.32 High High
Nerve growth factor 5 88.12 High High
Disease Link Frequency Relevance Heat
Autoimmune Disease 125 99.56 Very High Very High Very High
Alzheimer's Dementia 108 99.24 Very High Very High Very High
Disease 480 99.12 Very High Very High Very High
INFLAMMATION 281 99.04 Very High Very High Very High
Multiple Sclerosis 68 98.80 Very High Very High Very High
Experimental Arthritis 100 98.64 Very High Very High Very High
Amyloid Plaque 33 98.64 Very High Very High Very High
Encephalitis 20 98.08 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 97.68 Very High Very High Very High
Demyelinating Disease 35 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CD40-CD40L interaction, which was initially shown to have important roles in the T cell-mediated activation of B cells during humoral immune responses, is now known to have roles in activation of endothelial cells, smooth muscle cells, and macrophages within atherosclerotic plaques.
CD40-CD40L Binding (interaction) of in B cells associated with atherosclerotic plaque
1) Confidence 0.45 Published 1999 Journal Cardiology Section Abstract Doc Link 10640791 Disease Relevance 0.35 Pain Relevance 0
Suppression of the CD40-CD154 interaction has been shown to actually induce generation of T regulatory (Treg) cells [8].
CD154 Binding (interaction) of
2) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.90 Pain Relevance 0.37
This therapy is highly effective in mouse models [4,18], although the overall benefit of interruption of CD40-CD154 association is reduced when Abs is administrated after disease establishment.
CD154 Binding (association) of associated with disease
3) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.82 Pain Relevance 0.22
The CD40-CD40L interaction, which was initially shown to have important roles in the T cell-mediated activation of B cells during humoral immune responses, is now known to have roles in activation of endothelial cells, smooth muscle cells, and macrophages within atherosclerotic plaques.
CD40-CD40L Binding (interaction) of in B cells associated with atherosclerotic plaque
4) Confidence 0.35 Published 1999 Journal Cardiology Section Abstract Doc Link 10640791 Disease Relevance 0.35 Pain Relevance 0
One of these strategies involves blockade of the binding of CD40 to CD40 ligand (CD40L, also known as CD154).
CD40L Binding (ligand) of
5) Confidence 0.33 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.29 Pain Relevance 0.03
One of these strategies involves blockade of the binding of CD40 to CD40 ligand (CD40L, also known as CD154).
CD40L Binding (blockade) of
6) Confidence 0.33 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.29 Pain Relevance 0.03
Blockage of the CD40-CD154 interaction has been reported to alter cytokine production [16].
CD154 Binding (interaction) of associated with cytokine
7) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.27 Pain Relevance 0.19
However, the finding that IL-2 deficient mice are able to mount primary CD8+ T cell responses and that CD4+ T cells condition DC, through CD40L/CD40 interactions, to efficiently prime CD8+ T cells disfavored the original hypothesis [33], [34], [35], [45].
CD40L Binding (interactions) of in T cells
8) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.06 Pain Relevance 0.06
These effects on enhanced cytokine production could be blocked by the addition of an antagonistic CD40 antibody, confirming the requirement of the CD40-CD40L interaction per se in this phenomenon.
CD40L Binding (interaction) of associated with cytokine
9) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.29 Pain Relevance 0.28
In an effort to further understand the nature of the CD40-CD40L interaction responsible for promotion of EAE, Becher and colleagues used a bone marrow reconstitution system to determine which CD40-expressing cells were responsible for promoting EAE [57].
CD40L Binding (interaction) of in bone marrow associated with multiple sclerosis
10) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.78 Pain Relevance 0.08
-amyloid plaques in AD patient brain [78,79], raising the possibility that the CD40-CD40L interaction may contribute to AD pathogenesis by promoting brain inflammation.
CD40L Binding (interaction) of in plaques associated with inflammation, alzheimer's dementia, encephalitis and amyloid plaque
11) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 1.08 Pain Relevance 0.05
In addition to the CD80/86-CD28 interaction, co-stimulation of T cell responses occurs through the CD40-CD154 interaction between APCs and T cells.
CD154 Binding (interaction) of in T cell
12) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 1.07 Pain Relevance 0.49
The CD40-CD154 interaction is involved in the initiation of CIA.
CD154 Binding (interaction) of associated with arthritis
13) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.80 Pain Relevance 0.19
CD40L: CD40 ligand
CD40L Binding (ligand) of
14) Confidence 0.26 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.61 Pain Relevance 0.32
Given the recently described immunomodulatory role of cannabinoids, the importance of CD40-CD40L interaction in neuroinflammatory diseases, and the clinical and basic science studies suggesting that cannabinoids may be therapeutic in AD and MS, [21-25], we examined, in the present study, whether cannabinoids (primarily CB2 agonist JWH-015) could oppose microglial CD40 expression following interferon-?
CD40L Binding (interaction) of associated with multiple sclerosis, cannabinoid, agonist and disease
15) Confidence 0.26 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.84 Pain Relevance 0.42
B plays a critical role in addition to, and prior to, the engagement of infected cells with CD40L in germinal center reactions.
CD40L Binding (engagement) of
16) Confidence 0.25 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.05 Pain Relevance 0
Engagement of primary B cells with CD40L leads to the activation of NF-?
CD40L Binding (Engagement) of in B cells
17) Confidence 0.25 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.44 Pain Relevance 0.08
Based on the conspicuous role of the CD40-CD40L interaction in mediating brain pro-inflammatory responses and exacerbating AD-like pathology, we investigated the impact of HUCBC administration to AD mice on CD40 pathway-mediated immune responses [186].
CD40-CD40L Binding (interaction) of in brain associated with inflammatory response and disease
18) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 1.13 Pain Relevance 0.12
CD40 is expressed on antigen presenting cells and binds to CD40L (or CD154) on CD4+ T helper cells.
CD40L Binding (binds) of
19) Confidence 0.22 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2943198 Disease Relevance 0.86 Pain Relevance 0.43
CD40 is expressed on antigen presenting cells and binds to CD40L (or CD154) on CD4+ T helper cells.
CD154 Binding (binds) of
20) Confidence 0.22 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2943198 Disease Relevance 0.87 Pain Relevance 0.44

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox