INT85967

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.22
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pecam1) cell adhesion (Pecam1) plasma membrane (Pecam1)
Anatomy Link Frequency
endothelial cells 2
blood vessel 2
lymphocytes 2
platelet 2
Pecam1 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 2 99.08 Very High Very High Very High
ischemia 111 98.84 Very High Very High Very High
Hippocampus 33 96.64 Very High Very High Very High
Angina 3 91.80 High High
Cannabinoid 2 91.12 High High
Inflammation 38 88.08 High High
cytokine 9 87.04 High High
chemokine 24 79.52 Quite High
alcohol 2 70.16 Quite High
Morphine 1 70.00 Quite High
Disease Link Frequency Relevance Heat
Adhesions 27 100.00 Very High Very High Very High
Myocardial Infarction 72 99.08 Very High Very High Very High
Transient Ischemic Attack 20 98.84 Very High Very High Very High
Cancer 86 98.66 Very High Very High Very High
Cv Unclassified Under Development 88 98.24 Very High Very High Very High
Infarction 3 97.84 Very High Very High Very High
Stress 105 95.12 Very High Very High Very High
Rupture 1 94.40 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 112 93.36 High High
Cv General 3 Under Development 3 91.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result coincided with a previous study which reported that PECAM-1 immunoreactivity and protein levels were significantly increased in the hippocampal CA1 region 4 days after ischemia/reperfusion (Hwang et al., 2005).
Positive_regulation (increased) of Gene_expression (immunoreactivity) of PECAM-1 associated with ischemia
1) Confidence 0.50 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.22 Pain Relevance 0.30
However, in this study, we observed that PECAM-1 immunoreactivity
Positive_regulation (observed) of Gene_expression (immunoreactivity) of PECAM-1
2) Confidence 0.50 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.05 Pain Relevance 0.38
The expression levels of CD31 were increased in a small portion of the ACS patients.
Positive_regulation (increased) of Gene_expression (expression) of CD31
3) Confidence 0.35 Published 1999 Journal Cardiology Section Abstract Doc Link 10640791 Disease Relevance 1.01 Pain Relevance 0.25
To examine the effect of endothelial Rac1-depletion on tumor angiogenesis, blood vessel density was quantified by counting the numbers of PECAM-1+/GFP?
Positive_regulation (numbers) of Gene_expression (numbers) of PECAM in blood vessel associated with cancer
4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.97 Pain Relevance 0
/CD31+ endothelial cells increased significantly within the LacZ+ cell population after infarction. c The amount of Sca?
Positive_regulation (increased) of Gene_expression (endothelial cells) of CD31 in endothelial cells associated with infarction
5) Confidence 0.30 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.59 Pain Relevance 0.03
The accumulation of lymphocytes in liver sinusoids (devoid of E/P-selectins, PECAM, CD34, and VE-cadherin, and low in VCAM-1) appears to result from mechanisms distinct from those involved in multistep extravasation of intravascular lymphocytes [14].
Positive_regulation (accumulation) of Gene_expression (devoid) of PECAM in lymphocytes
6) Confidence 0.29 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.34 Pain Relevance 0.04
In an in vitro BBB model comprising endothelial cells and astrocytes, cocaine was also found to decrease barrier function, increase expression of ICAM-1, VCAM-1 and platelet-endothelial cell adhesion molecule (PECAM)-1, and to enhance monocyte migration across the BBB [134].
Positive_regulation (increase) of Gene_expression (expression) of platelet-endothelial cell adhesion molecule in platelet associated with adhesions and cocaine
7) Confidence 0.21 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.04 Pain Relevance 0.39

General Comments

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