INT85968

Context Info Confidence 0.69 First Reported 1999 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 19 Total Number 32 Disease Relevance 29.04 Pain Relevance 7.50

extracellular space (Pecam1) cell adhesion (Pecam1) plasma membrane (Pecam1)

Anatomy Link Frequency plugs 2 dentate gyrus 1 cerebrospinal fluid 1 platelet 1 endothelial cell 1 Pecam1 (Mus musculus)

Pain Link Frequency Relevance Heat allodynia 4 99.90 ischemia 830 99.84 Inflammation 330 98.00 Hippocampus 225 96.24 Pyramidal cell 56 94.12 Angina 3 90.96 Mechanotransduction 6 90.56 antagonist 37 89.60 cytokine 75 88.84 Neuropathic pain 2 75.00

Disease Link Frequency Relevance Heat Adhesions 116 100.00 Neuropathic Pain 6 99.90 Cv Unclassified Under Development 647 99.84 Stroke 151 99.84 Injury 129 99.72 Stress 735 99.12 Transient Ischemic Attack 142 98.80 Myocardial Infarction 568 98.20 INFLAMMATION 369 98.00 Death 152 97.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It has also been reported that serum PECAM-1 levels were significantly elevated in stroke patients (Zaremba & Losy, 2002a, b).

Positive_regulation (elevated) of PECAM-1 associated with stroke

1) Confidence 0.69 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.04 Pain Relevance 0.31

PECAM-1 levels increase significantly in serum and cerebrospinal fluid of patients within 24 hours after an ischemic stroke (Zaremba & Losy, 2002b).

Positive_regulation (increase) of PECAM-1 in cerebrospinal fluid associated with stroke

2) Confidence 0.69 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.13 Pain Relevance 0.35

The elevation of PECAM-1 in vessels is known to increase the transmigration of lymphocytes and neutrophils (Dangerfield et al., 2002; Michiels et al., 1998).

Positive_regulation (elevation) of PECAM-1 in neutrophils

3) Confidence 0.69 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.22 Pain Relevance 0.31

In the ischemia-group, both PECAM-1 immunoreactivity and protein levels were significantly increased in all the hippocampal subregions 4 days after ischemia/reperfusion.

Positive_regulation (increased) of PECAM-1 associated with ischemia

4) Confidence 0.69 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.30 Pain Relevance 0.30

Four days after ischemia/reperfusion, PECAM-1 immunoreactivity was significantly increased in the ischemia-groups (Fig. 3C, E, G, 4).

Positive_regulation (increased) of PECAM-1 associated with ischemia

5) Confidence 0.50 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.42 Pain Relevance 0.56

In addition, we observed a considerable increase of PECAM-1 immunoreactivity in the CA1 region of the ischemia-group, compared to a moderate increase in the CA2/3 region and dentate gyrus.

Positive_regulation (increase) of PECAM-1 in dentate gyrus associated with ischemia

6) Confidence 0.50 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.02 Pain Relevance 0.33

In addition, PECAM-1 immunoreactivity and protein levels have been shown to be significantly increased in the hippocampal CA1 region 4 days after ischemia/reperfusion (Hwang et al., 2005).

Positive_regulation (increased) of PECAM-1 associated with ischemia

7) Confidence 0.46 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.27 Pain Relevance 0.36

However, there was no significant increase on PECAM-1 protein level in the stress-ischemia-group: it was similar to that in the sham-group (Fig. 5).

Neg (no) Positive_regulation (increase) of PECAM-1 associated with stress and ischemia

8) Confidence 0.46 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.74 Pain Relevance 0.57

Four days after ischemia/reperfusion, PECAM-1 protein level was significantly increased in the ischemia-group: PECAM-1 protein level was increased to about 340% of that in the sham-group.

Positive_regulation (increased) of PECAM-1 associated with ischemia

9) Confidence 0.46 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.74 Pain Relevance 0.59

In the ischemia-group, PECAM-1 immunoreactivity and its protein levels were significantly increased in all the hippocampal subregions 4 days after ischemia/reperfusion.

Positive_regulation (increased) of PECAM-1 associated with ischemia

10) Confidence 0.46 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC2998780 Disease Relevance 1.56 Pain Relevance 0.53

Four days after ischemia/reperfusion, PECAM-1 protein level was significantly increased in the ischemia-group: PECAM-1 protein level was increased to about 340% of that in the sham-group.

Positive_regulation (increased) of PECAM-1 associated with ischemia

11) Confidence 0.46 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.69 Pain Relevance 0.59

The degree of increase in PECAM-1 may therefore be associated with the regional vulnerability post transient cerebral ischemia.

Positive_regulation (increase) of PECAM-1 associated with transient ischemic attack and ischemia

12) Confidence 0.46 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.08 Pain Relevance 0.39

This result coincided with a previous study which reported that PECAM-1 immunoreactivity and protein levels were significantly increased in the hippocampal CA1 region 4 days after ischemia/reperfusion (Hwang et al., 2005).

Positive_regulation (increased) of PECAM-1 associated with ischemia

13) Confidence 0.46 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.22 Pain Relevance 0.30

Flow cytometric analysis showing a significant increase of LacZ+ cells in both Sca-1+ (b) and CD31+ (d) cell populations, parallel with an increase in total Sca+ (a) and CD31+ (c) cell numbers.

Positive_regulation (increase) of CD31

14) Confidence 0.41 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.79 Pain Relevance 0

Flow cytometric analysis showing a significant increase of LacZ+ cells in both Sca-1+ (b) and CD31+ (d) cell populations, parallel with an increase in total Sca+ (a) and CD31+ (c) cell numbers.

Positive_regulation (increase) of CD31

15) Confidence 0.41 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.73 Pain Relevance 0

From this point, it is at least striking that we observed a significant increase in Sca+/CD31?

Positive_regulation (increase) of CD31

16) Confidence 0.41 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.37 Pain Relevance 0

In addition, a significant increase in Sca+/CD31?

Positive_regulation (increase) of CD31

17) Confidence 0.41 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.39 Pain Relevance 0

In contrast, persistent mechanical allodynia and enhanced spinal PECAM, ICAM, MHC class II and CD4 immunoreactivity was observed following peripheral nerve transection.

Positive_regulation (enhanced) of PECAM in peripheral nerve associated with allodynia

18) Confidence 0.40 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960644 Disease Relevance 1.04 Pain Relevance 0.63

The tendency for increased number of CD31 positive structures (vessels with lumen, vessels without lumen and single cells) was observed in HF group, however differences between diets were not statistically significant (Fig. 1).

Positive_regulation (increased) of CD31 in vessels

19) Confidence 0.39 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.56 Pain Relevance 0

In patients, VCAM-1 was increased up to 5 days after symptom onset while ICAM-2 and PECAM-1 were not increased after injury [123,124].

Neg (not) Positive_regulation (increased) of PECAM-1 associated with injury

20) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 1.01 Pain Relevance 0.06

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