INT85970

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Context Info
Confidence 0.53
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 8.51
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cd40lg) extracellular space (Cd40lg) extracellular region (Cd40lg)
plasma membrane (Cd40lg)
Anatomy Link Frequency
platelet 5
T cells 2
CD86 1
Cd40lg (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory marker 84 100.00 Very High Very High Very High
Angina 32 98.88 Very High Very High Very High
cytokine 38 98.84 Very High Very High Very High
withdrawal 84 98.00 Very High Very High Very High
Inflammation 258 97.04 Very High Very High Very High
aspirin 108 83.40 Quite High
abatacept 9 80.84 Quite High
rheumatoid arthritis 34 77.24 Quite High
Pain 4 75.64 Quite High
cva 5 68.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 342 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 64 99.68 Very High Very High Very High
Acute Coronary Syndrome 43 99.54 Very High Very High Very High
Cv General 3 Under Development 25 98.88 Very High Very High Very High
Angina 12 96.12 Very High Very High Very High
Renal Disease 22 94.32 High High
Thrombosis 66 91.16 High High
Myocardial Infarction 27 90.36 High High
Atherosclerotic Plaque 2 86.76 High High
Encephalitis 4 83.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, we could not document any increase in CD154 (the CD40 ligand) on T cells, and therefore decided not to include CD154 in our standard panel.
Positive_regulation (increase) of CD154 in T cells
1) Confidence 0.53 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.27 Pain Relevance 0.03
CONCLUSIONS: Patients with unstable angina show an enhanced coagulation activation and an upregulation of CD40L on platelets.
Positive_regulation (upregulation) of CD40L in platelets
2) Confidence 0.48 Published 2006 Journal Int. J. Cardiol. Section Body Doc Link 16182391 Disease Relevance 0 Pain Relevance 0
CD40L levels increased from a median of 224 to 324.5 pg/ml by week four after clopidogrel cessation (Table 3A).
Positive_regulation (increased) of CD40L
3) Confidence 0.45 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.68 Pain Relevance 0.30
In the patients with acute coronary syndrome, the average level of CD40L showed a significant increase (p = 0.0028), while stable angina patients did not have any increase when compared to normal subjects.
Positive_regulation (increase) of CD40L associated with acute coronary syndrome and angina
4) Confidence 0.44 Published 1999 Journal Cardiology Section Abstract Doc Link 10640791 Disease Relevance 1.07 Pain Relevance 0.28
CD40L activation in circulating platelets in patients with acute coronary syndrome.
Positive_regulation (activation) of CD40L in platelets associated with acute coronary syndrome
5) Confidence 0.44 Published 1999 Journal Cardiology Section Title Doc Link 10640791 Disease Relevance 0.78 Pain Relevance 0.18
This opposite effect suggests that the increase in sCD40L levels reflects solely the removal of the inhibitory effects of clopidogrel on platelet activity rather than an increase in pro-inflammatory state.
Positive_regulation (increase) of sCD40L in platelet associated with inflammation
6) Confidence 0.39 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.55 Pain Relevance 0.26
We observed, however, the greatest sCD40L upregulation after clopidogrel discontinuation in patients treated with zotarolimus-eluting stents compared to sirolimus and paclitaxel drug eluting stents.
Positive_regulation (upregulation) of sCD40L
7) Confidence 0.39 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.71 Pain Relevance 0.25
CD40 is constitutively expressed on B cells; its ligand CD154 is induced on CD4+ T cells upon activation.
Positive_regulation (induced) of CD154 in T cells
8) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.55 Pain Relevance 0.10
Changes in inflammatory markers such as sCD40L, soluble P-selectin and hsCRP over 4 weeks after withdrawal of clopidogrel are shown in Table 3 (medians and interquartile ranges) and as mean percentage changes from baseline levels obtained at 12 months after clopidogrel administration.
Positive_regulation (Changes) of sCD40L associated with inflammatory marker and withdrawal
9) Confidence 0.28 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.78 Pain Relevance 0.33
Further studies should elucidate if this increase in sCD40L levels reflects solely the removal of the inhibitory effects of clopidogrel on platelet activity or rather an increase in pro-inflammatory state.
Positive_regulation (increase) of sCD40L in platelet associated with inflammation
10) Confidence 0.26 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.28 Pain Relevance 0.15
Patients treated with drug eluting stents at 1 year after implantation display significant increase in sCD40L and decrease in hsCRP after clopidogrel cessation.
Positive_regulation (increase) of sCD40L
11) Confidence 0.26 Published 2009 Journal J Thromb Thrombolysis Section Abstract Doc Link PMC2766044 Disease Relevance 0.05 Pain Relevance 0.03
Patients who were treated with zotarolimus stents appeared to have the greatest upregulation of sCD40L after clopidogrel discontinuation compared to the patients treated with paclitaxel, sirolimus eluting stents or bare metal stents (Fig. 3).
Positive_regulation (upregulation) of sCD40L
12) Confidence 0.26 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.16 Pain Relevance 0.16
Further studies should elucidate if this increase in sCD40L levels reflects solely the removal of the inhibitory effects of clopidogrel on platelet activity or rather an increase in pro-inflammatory state.
Positive_regulation (increase) of sCD40L in platelet associated with inflammation
13) Confidence 0.26 Published 2009 Journal J Thromb Thrombolysis Section Abstract Doc Link PMC2766044 Disease Relevance 0.09 Pain Relevance 0.08
Increase in CD40L varied with drug eluting stent used.
Positive_regulation (Increase) of CD40L
14) Confidence 0.26 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.28 Pain Relevance 0.18
Zotarolimus stent implantation appears to be associated with the highest sCD40L upregulation after stopping clopidogrel but the clinical significance of this observation is uncertain.



Positive_regulation (upregulation) of sCD40L
15) Confidence 0.26 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.21 Pain Relevance 0.13
Patients treated with drug eluting stents at 1 year after implantation display significant increase in sCD40L and decrease in hsCRP after clopidogrel cessation.
Positive_regulation (increase) of sCD40L
16) Confidence 0.26 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.28 Pain Relevance 0.15
The degree of sCD40L upregulation was dependent on baseline levels.
Positive_regulation (upregulation) of sCD40L
17) Confidence 0.26 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.11 Pain Relevance 0.05
CD40L is over-expressed in T helper cells of SLE patients16 and sCD40L is elevated in the serum of patients.
Positive_regulation (elevated) of sCD40L associated with systemic lupus erythematosus
18) Confidence 0.25 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2943198 Disease Relevance 0.88 Pain Relevance 0.36
Initial suboptimal stimulation of CD4+ T cells induces CD154 to engage CD40 on DCs, which then upregulates the expression of CD80 and CD86, facilitating further co-stimulation through CD28.
Positive_regulation (induces) of CD154 in CD86
19) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.10 Pain Relevance 0
CONCLUSIONS: Soluble CD40L was significantly elevated in patients with more advanced symptomatic PAD and might be an indicator for disease extent stratification.
Positive_regulation (elevated) of CD40L
20) Confidence 0.21 Published 2006 Journal Thromb. Res. Section Body Doc Link 16356539 Disease Relevance 0 Pain Relevance 0

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